Target and Its Patented Drug(s)
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T15441 | Target Info | |||
| Target Name | Ubiquitin C-terminal hydrolase UCH37 (UCHL5) | ||||
| Synonyms | Ubiquitin thioesterase L5; Ubiquitin carboxyl-terminal hydrolase isozyme L5; UCH37; UCH-L5; CGI-70; AD-019 | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | UCHL5 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Patent(s) and the Corresponding Patented Drug(s) | Top | ||||
|---|---|---|---|---|---|
| World Intellectual Property Organization (WIPO) | |||||
| Patent ID | WO2013058691 | ||||
| Title | Method for Inhibition of Deubiquitinating Activity. | ||||
| Abstract | A compound of the general structure (I) is capable of abrogating the deubiquitinating (DUB) activity of the 19S RP DUBs. The compound can be used for treating cancer, in particular of cancer refractory to treatment by state-of-the-art chemotherapy. Also disclosed are corresponding methods of treatment and a pharmaceutical composition comprising the compound. | ||||
| Applicant(s) | LINDER, Stig et al | ||||
| Representative Drug(s) | D0A8EN | Drug Info | N.A. | [1] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Deubiquitinases (DUBs) and DUB inhibitors: a patent review.Expert Opin Ther Pat. 2015;25(10):1191-1208. | ||||
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