Target and Its Patented Drug(s)
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T16215 | Target Info | |||
| Target Name | Smoothened D473H mutant (SMO D473H) | ||||
| Synonyms | Smo-D473H mutant; SMOH D473H mutant; Protein Gx D473H mutant | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | SMO | ||||
| Biochemical Class | GPCR frizzled | ||||
| UniProt ID | |||||
| Patent(s) and the Corresponding Patented Drug(s) | Top | ||||
|---|---|---|---|---|---|
| World Intellectual Property Organization (WIPO) | |||||
| Patent ID | WO2014043608 | ||||
| Title | Smoothened Modulators and Methods of Use Thereof. | ||||
| Abstract | Compounds of general Formulas (I), (IA), (IB) are described, along with compositions containing the same and methods of use thereof, inhibiting the hedgehog pathway in a cell or inhibiting unwanted proliferation of a cell. | ||||
| Applicant(s) | Duke University | ||||
| Representative Drug(s) | D07BIQ | Drug Info | Ki = 480 nM | [1] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. | ||||
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