Target and Its Patented Drug(s)

Content Navigation (  All   None )                                      
Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T40890 Target Info
Target Name Zinc finger protein GLI1 (Gli1)
Synonyms Oncogene GLI; Glioma-associated oncogene; GLI
Target Type Patented-recorded Target
Gene Name GLI1
UniProt ID
GLI1_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
World Intellectual Property Organization (WIPO)
Patent ID WO2014207069
Title Multitarget Hedgehog Pathway Inhibitors and Uses Thereof.
Abstract The present invention concerns compounds that selectively inhibit the activity of the Hedgehog (Hh) pathway, their preparation and uses thereof. The compounds of the present invention are useful in treating Hh-dependent tumors, such as medulloblastoma (MB).
Applicant(s) Universita 'Degli Studi Di Siena
Representative Drug(s) D00RRB Drug Info N.A. Click to Show More [1]
2 D01BGG Drug Info N.A. [1]
3 D04IFL Drug Info N.A. [1]
4 D05NRG Drug Info N.A. [1]
5 D09VIE Drug Info N.A. [1]
6 D0J1RB Drug Info N.A. [1]
7 D0TP0S Drug Info N.A. [1]
8 D0WI1G Drug Info N.A. [1]
9 D0Z6IS Drug Info N.A. [1]
Patent ID WO2013192301
Title Imidazo Bicyclic Imminium Compounds As Antitumor Agents.
Abstract Imidazobicycles having a quaternary nitrogen, i.e. imminium salts, are disclosed. Examples include derivatives of 6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepinium and 2,3-dihydroimidazo[2,1-b]thiazolium salts. The compounds are inhibitors of the Hedgehog pathway and therefore useful as antitumor agents and as probes of the function of Hedgehog-dependent systems.
Applicant(s) The Board of Trustes of the Leland Stanford Junior University
Representative Drug(s) D0FL0T Drug Info N.A. Click to Show More [2]
2 D0II7X Drug Info N.A. [2]
Patent ID WO2014116651
Title Targeting Gli Proteins In Human Cancer By Small Molecules.
Abstract The present disclosure provides compositions, pharmaceutical preparations and methods for the diagnosis and treatment of cancers expressing a GLI polypeptide. The disclosed compositions and pharmaceutical preparations may comprise one or more pyrazolyl-containing compounds, or an analog or derivative thereof.
Applicant(s) The Regents of the University of California
Representative Drug(s) D00KXJ Drug Info N.A. [1]
Patent ID WO2007067814
Title Targeting Gli Proteins In Human Cancer By Small Molecules.
Abstract This invention provides compositions, methods and kits for the diagnosis and treatment of cancers expressing a GLI polypeptide, and in particular a GLI1, GLI2 or GLI3 polypeptide. The invention provides small molecule compounds mimicking the transcriptional activation domain of a GLI polypeptide. The small molecule inhibitors of the invention specifically block the activator function of a GLI polypeptide, but not the repressor function of GLI3.
Applicant(s) The Regents of the University of California
Representative Drug(s) D00KXJ Drug Info N.A. [1]
United States Patent and Trademark Office (USPTO)
Patent ID US2015191489
Title Imidazo Bicyclic Imminium Compounds As Antitumor Agents.
Applicant(s) The Board of Trustes of the Leland Stanford Junior University
Representative Drug(s) D0FL0T Drug Info N.A. Click to Show More [1]
2 D0II7X Drug Info N.A. [1]
References  Top
REF 1 Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Expert Opin Ther Pat. 2016;26(4):529-35.
REF 2 Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.