Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T53585 Target Info
Target Name HMG-CoA reductase (HMGCR)
Synonyms 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Target Type Successful Target
Gene Name HMGCR
Biochemical Class CH-OH donor oxidoreductase
UniProt ID
HMDH_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
World Intellectual Property Organization (WIPO)
Patent ID WO2010103318
Title Rosuvastatin and Atorvastatin Derivatives.
Abstract his invention relates to the discovery of novel rosuvastatin and atorvastatin analogues.
Applicant(s) Redx Pharma Limited
Representative Drug(s) D09ZXW Drug Info N.A. Click to Show More [1]
2 D0CM4R Drug Info N.A. [1]
Patent ID WO2013171100
Title Polyhydroxylated Pentacyclic Triterpene Acids As Hmg-Coa Reductase Inhibitors.
Abstract The present invention relates to certain polyhydroxylated pentacyclic triterpene acids of formula (I) for use as HMG-Co A reductase inhibitors in the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to a reduction of the HMG-Co A reductase activity in a mammal, preferably a human being. The present invention further relates to certain mixtures and plant extracts comprising euscaphic acid and tormentic acid, wherein the amount of euscaphic acid to tormentic acid exceeds a certain ratio. Further, the present invention also relates to a formulation, preferably pharmaceutical or nutraceutical formulation, comprising one or more of said compounds of formula (I), a composition according to the present invention or a plant extract according to the present invention. Also, the present invention relates to a process for obtaining certain polyhydroxylated pentacyclic triterpene acids of formula (I), a composition according to the present invention or a plant extract according to the present invention.
Applicant(s) Joachim Hans et al
Representative Drug(s) D0S3BE Drug Info N.A. [1]
Patent ID WO2013113294
Title Sterol Derivative, Preparation Method Therefor and Use Thereof.
Abstract Disclosed in the present invention are a sterol derivative, preparation method therefor and use thereof. Said sterol derivative comprises sterol compounds having structure according to formula (I), or.
Applicant(s) Beijing Peking University Wbl Biotech Co., Ltd
Representative Drug(s) D0YZ3U Drug Info N.A. [1]
Patent ID WO2010103320
Title Use of Rosuvastatin Lactols As Medicaments.
Abstract This invention relates to the discovery of novel rosuvastatin analogues. More specifically, the invention relates to novel rosuvastatin analogues which have utility in treating conditions treatable by the inhibition of HMG-CoA reductase.
Applicant(s) Redx Pharma Limited
Representative Drug(s) D0CM4R Drug Info N.A. [1]
Patent ID WO2010103319
Title Use of Atorvastatin Lactols As Medicaments.
Abstract This invention relates to the discovery of novel atorvastatin analogues. More specifically, the invention relates to novel atorvastatin analogues which have utility in treating conditions treatable by the inhibition of HMG-CoA reductase.
Applicant(s) Redx Pharma Limited
Representative Drug(s) D09ZXW Drug Info N.A. [1]
Patent ID WO2008077305
Title Quinoline Compounds, Intermediates, Prepartion Methods and Uses Thereof.
Abstract A kind of quinoline compounds as formula A, pharmaceutical accepted solvates, optical isomers or polymorphisms thereof. The intermediates of formula D. in which, R1, R2 and R3 is independently H, halo or the subustitents of formula H, in which, R is H, halo, C1~C4alkyl, C1~C4alkoxyl. The preparation methods and the the uses for the manufacture of a medicament of inhibiting the HMG CoA reductase and treating the diseases relating to the high blood fat. Compared with the fluvastatin, rosuvatatin, pitavastatin disclosed in the prior arts, present quinoline compounds have better activity of inhibiting HMG CoA reductase. Present quinoline compounds can be used for treating the diseases relating to the high blood fat.
Applicant(s) Shanghai Inst Pharm Industry
Representative Drug(s) D0QW7F Drug Info N.A. [1]
Patent ID WO2013097681
Title Sterols Derivative, and Preparation Method and Purpose Thereof.
Abstract The present invention relates to the field of pharmaceutical chemicals, and provides a sterols derivative, and a preparation method and purpose thereof. Specifically, the present invention relates to.
Applicant(s) Beijing Peking University Wbl Biotech Co., Ltd
Patent ID WO2008034117
Title Methods for Using Soy Peptides To Inhibit H3 Acetylation, Reduce Expression of Hmg-Coa Reductase and Increase Ldl Receptor and Sp1 Expression In A Mammal.
Abstract Controlled studies demonstrate that methods using soy related peptides inhibit H3 acetylation, reduce expression of HMG-CoA reductase and increase LDL receptor and Sp1 expression in mammals. The present disclosure is generally directed to using lunasin peptides and/or lunasin peptide derivatives to 1) inhibit H3 acetylation, 2) reduce expression of HMG-CoA reductase, 3) increase LDL receptor expression or 4) increase Sp1 expression in a mammal. In at least one exemplary embodiment of the present disclosure, an effective amount of lunasin peptides or lunasin peptide derivatives and one or more enzyme inhibitors is provided to a mammal to 1) inhibit H3 acetylation, 2) reduce expression of HMG-CoA reductase, 3) increase LDL receptor expression or 4) increase Sp1 expression in a mammal.
Applicant(s) Galvez
Patent ID WO2014145086
Title Products and Methods Using Lunasin-Enriched Soy Extract Mixtures To Reduce Free Fatty Acid Levels, Increase Leptin Levels and Increase Adiponectin Levels In Plasma.
United States Patent and Trademark Office (USPTO)
Patent ID US9102656
Title Use of Rosuvastatin Lactols As Medicaments.
Applicant(s) Redx Pharma Ltd
Representative Drug(s) D0AY4N Drug Info IC50 < 1 nM Click to Show More [1]
2 D0CM4R Drug Info N.A. [1]
Patent ID US9006282
Title Rosuvastatin and Atorvastatin Derivatives.
Applicant(s) Redx Pharma Ltd
Representative Drug(s) D09ZXW Drug Info N.A. Click to Show More [1]
2 D0CM4R Drug Info N.A. [1]
Patent ID US8513412
Title Rosuvastatin and Atorvastatin Derivatives.
Applicant(s) Bradford Pharma Ltd
Representative Drug(s) D09ZXW Drug Info N.A. Click to Show More [1]
2 D0CM4R Drug Info N.A. [1]
Patent ID US20130303773
Title Rosuvastatin and Atorvastatin Derivatives.
Applicant(s) Redx Pharma Ltd
Representative Drug(s) D09ZXW Drug Info N.A. Click to Show More [1]
2 D0CM4R Drug Info N.A. [1]
Patent ID US20110319617
Title Rosuvastatin and Atorvastatin Derivatives.
Applicant(s) Bradford Pharma Ltd
Representative Drug(s) D09ZXW Drug Info N.A. Click to Show More [1]
2 D0CM4R Drug Info N.A. [1]
Patent ID US8349867
Title Quinoline Compounds, Intermediates, Preparation Methods and Uses Thereof.
Applicant(s) The Shanghai Institute of Pharmaceutical Industry
Representative Drug(s) D0QW7F Drug Info N.A. [1]
Patent ID US20150025130
Title Sterol Derivative, Preparation Method Therefor and Use Thereof.
Applicant(s) Univ Beijing Peking Wbl Biotech Co Ltd
Representative Drug(s) D0YZ3U Drug Info N.A. [1]
Patent ID US20140206645
Title Dual Action Inhibitors Against Histone Deacetylases and 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase.
Applicant(s) Academia Sinica (Taipei, Tw)
Representative Drug(s) D0L3BE Drug Info N.A. [1]
Patent ID US20140018381
Title Use of Rosuvastatin Lactols As Medicaments.
Applicant(s) Redx Pharma Ltd
Representative Drug(s) D0CM4R Drug Info N.A. [1]
Patent ID US20120004408
Title Use of Rosuvastatin Lactols As Medicaments.
Applicant(s) Bradford Pharma Ltd
Representative Drug(s) D0CM4R Drug Info N.A. [1]
Patent ID US2011046379
Title Quinoline Compounds, Intermediates, Preparation Methods and Uses Thereof.
Applicant(s) The Shanghai Institute of Pharmaceutical Industry
Representative Drug(s) D0QW7F Drug Info N.A. [1]
Patent ID US20110319626
Title Use of Atorvastatin Lactols As Medicaments.
Applicant(s) Bradford Pharma Ltd
Representative Drug(s) D09ZXW Drug Info N.A. [1]
Patent ID US2015133552
Title Polyhydroxylated Pentacyclic Triterpene Acids As Hmg-Coa Reductase Inhibitors.
Representative Drug(s) D0S3BE Drug Info N.A. [1]
Patent ID US20130310450
Title Compound separated from monascus-fermented rice,the preparation method and uses thereof.
Representative Drug(s) D0M9ZW Drug Info N.A. [1]
Patent ID US9115116
Title Dual Action Inhibitors Against Histone Deacetylases and 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase.
Applicant(s) Academia Sinica (Taipei, Tw)
Patent ID US7731995
Title Methods for Using Soy Peptides To Inhibit H3 Acetylation, Reduce Expression of Hmg Coa Reductase, and Increase Ldl Receptor and Sp1 Expression In A Mammal.
European Patent Office (EPO)
Patent ID EP2614822
Title Atorvastatin Derivatives.
Applicant(s) Redx Pharma Ltd
Representative Drug(s) D09ZXW Drug Info N.A. Click to Show More [1]
2 D0CM4R Drug Info N.A. [1]
Patent ID EP2405910
Title Rosuvastatin and Atorvastatin Derivatives.
Applicant(s) Redx Pharma Ltd
Representative Drug(s) D09ZXW Drug Info N.A. Click to Show More [1]
2 D0CM4R Drug Info N.A. [1]
Patent ID EP2405972
Title Use of Rosuvastatin Lactols As Medicaments.
Applicant(s) Redx Pharma Ltd
Representative Drug(s) D0CM4R Drug Info N.A. [1]
Patent ID EP2405911
Title Use of Atorvastatin Lactols As Medicaments.
Applicant(s) Redx Pharma Ltd
Representative Drug(s) D09ZXW Drug Info N.A. [1]
Patent ID EP2812005
Title Polyhydroxylated Pentacyclic Triterpene Acids As Hmg-Coa Reductase Inhibitors.
Representative Drug(s) D0S3BE Drug Info N.A. [1]
Patent ID EP20070842567
Title Use of Soy Peptide (Lunasin) To Lower Total and Ldl Cholesterol Levels.
China National Intellectual Property Administration (CNIPA)
Patent ID CN103224490
Title Rosuvastatin and Atorvastatin Derivatives.
Applicant(s) Redx Pharma Ltd
Representative Drug(s) D09ZXW Drug Info N.A. Click to Show More [1]
2 D0CM4R Drug Info N.A. [1]
Patent ID CN102387800
Title Rosuvastatin and Atorvastatin Derivatives.
Applicant(s) Bradford Pharma Ltd
Representative Drug(s) D09ZXW Drug Info N.A. Click to Show More [1]
2 D0CM4R Drug Info N.A. [1]
Patent ID CN102153463
Title 4-Subsititued 3,5-Dihydroxy Carboxylic Acid Compound and Preparation Method Thereof.
Applicant(s) The Shanghai Institute of Technology
Representative Drug(s) D00YVL Drug Info IC50 = 40 nM [1]
Patent ID CN104529971
Title Hmg-Goa Reductase Inhibitor.
Applicant(s) Beijing Labworld Bio Medicine Technology Co Ltd
Representative Drug(s) D05SOY Drug Info N.A. [1]
Patent ID CN104356120
Title Polysubstitution Quinolines Pitavastatin Lactone Dewatering Compound and Application Thereof.
Applicant(s) The Shanghai Institute of Technology
Representative Drug(s) D0G8JX Drug Info N.A. [1]
Patent ID CN104327057
Title Poly-Substituted Indole Statin Lactone Dehydrated Compound and Use Thereof.
Applicant(s) The Shanghai Institute of Technology
Representative Drug(s) D0RW8J Drug Info N.A. [1]
Patent ID CN104159910
Title Sterol Derivative, Preparation Method Therefor and Use Thereof.
Applicant(s) Univ Beijing Peking Wbl Biotech Co Ltd
Representative Drug(s) D0YZ3U Drug Info N.A. [1]
Patent ID CN104024270
Title Sterols Derivative, and Preparation Method and Purpose Thereof.
Applicant(s) Univ Beijing Peking Wbl Biotech Co Ltd
Representative Drug(s) D08FMC Drug Info N.A. [1]
Patent ID CN103172693
Title Sterol Derivative, and Preparation Method and Application Thereof.
Applicant(s) Univ Beijing Peking Wbl Biotech Co Ltd
Representative Drug(s) D08FMC Drug Info N.A. [1]
Patent ID CN102816203
Title Substituted Quinoline Compound, and Preparation Method, Medicine Combination and Application Thereof.
Applicant(s) The Shanghai Institute of Pharmaceutical Industry
Representative Drug(s) D0U2CK Drug Info N.A. [1]
Patent ID CN102477032
Title 2-Cyclopropyl-4-Substituted-Phenoxy-Quinoline Derivatives, and Its Preparation Method, Intermediate and Application.
Applicant(s) The Shanghai Institute of Pharmaceutical Industry
Representative Drug(s) D0LJ0M Drug Info N.A. [1]
Patent ID CN102442997
Title Quinoline Derivative As Well As Preparation Method Thereof, Midbody and Application Thereof.
Applicant(s) The Shanghai Institute of Pharmaceutical Industry
Representative Drug(s) D04MFJ Drug Info N.A. [1]
Patent ID CN102387837
Title Use of Rosuvastatin Lactols As Medicaments.
Applicant(s) Bradford Pharma Ltd
Representative Drug(s) D0CM4R Drug Info N.A. [1]
Patent ID CN102387799
Title Use of Atorvastatin Lactols As Medicaments.
Applicant(s) Bradford Pharma Ltd
Representative Drug(s) D09ZXW Drug Info N.A. [1]
Patent ID CN102086184
Title 5-Fluorine-Substituted 4-Hydroxyl-3,4,5,6-Tetrahydro-2H-Pyrane-2-Ketone Compound and Preparation Method Thereof.
Applicant(s) The Shanghai Institute of Technology
Representative Drug(s) D0SH0L Drug Info N.A. [1]
Patent ID CN101967123
Title 2-Cyclopropyl-4-(N-Methyl Substituted Anilino) Quinoline Compound As Well As Intermediate, Preparation Method and Application Thereof.
Applicant(s) The Shanghai Institute of Pharmaceutical Industry
Representative Drug(s) D0EF9J Drug Info N.A. [1]
Patent ID CN101955477
Title 2-Cyclopropyl-4-Substituted Thiophenyl Quinoline Compounds As Well As Intermediate, Preparation Method and Application Thereof.
Applicant(s) The Shanghai Institute of Pharmaceutical Industry
Representative Drug(s) D03HKN Drug Info N.A. [1]
Patent ID CN101940576
Title Compound and Medicinal Use Thereof.
Applicant(s) Beijing Wbl Peking Univ Biotec
Representative Drug(s) D0O0OD Drug Info N.A. [1]
Patent ID CN101210011
Title Quinolines Compounds and Their Intermediates, Preparation Method and Application.
Applicant(s) The Shanghai Institute of Pharmaceutical Industry
Representative Drug(s) D0QW7F Drug Info N.A. [1]
Patent ID CN104356119
Title Polysubstitution Miazines Pitavastatin Lactone Dewatering Compound and Application Thereof.
Representative Drug(s) D0CW2F Drug Info N.A. [1]
Patent ID CN104356118
Title Polysubstitution Pyrroles Pitavastatin Lactone Dewatering Compound and Application Thereof.
Representative Drug(s) D0AP6V Drug Info N.A. [1]
Patent ID CN104356117
Title Tetrazole Ligand-Based One-Dimensional Zinc Compound and Preparation Method Thereof.
Representative Drug(s) D0YX0O Drug Info N.A. [1]
Patent ID CN102875504
Title Application of 4,5,6,7-Tetrahydro Pravastatin and Salts Thereof In Cardiovascular Diseases.
Representative Drug(s) D0KU2T Drug Info N.A. [1]
Patent ID CN104311517
Title Polysubstituted Phenanthrene Ring Statin Lactone Dehydrated Compounds and Application Thereof.
Applicant(s) The Shanghai Institute of Technology
Patent ID CN20141245686
Title Dipeptide Di with Double Functions of Reducing Blood Sugar and Blood Fat and Application Thereof.
Patent ID CN20131750012
Title Dipeptide Sd with Dual Functions of Lowering Blood Pressure and Blood Fat and Application Thereof.
Patent ID CN103755783
Title Dipeptide Qd with Double Functions of Lowering Blood Pressure and Lowering Blood Fat and Application Thereof.
Patent ID CN103755782
Title Dipeptide St with Double Functions of Lowering Blood Pressure and Lowering Blood Fat and Application Thereof.
Patent ID CN103736076
Title Dipeptide Dl with Double Functions of Lowering Blood Pressure and Lowering Blood Fat and Application Thereof.
Canadian Intellectual Property Office (CIPO)
Patent ID CA2754562
Title Rosuvastatin and Atorvastatin Derivatives.
Applicant(s) Bradford Pharma Ltd
Representative Drug(s) D09ZXW Drug Info N.A. Click to Show More [1]
2 D0CM4R Drug Info N.A. [1]
Patent ID CA2754825
Title Use of Rosuvastatin Lactols As Medicaments.
Applicant(s) Bradford Pharma Ltd
Representative Drug(s) D0CM4R Drug Info N.A. [1]
Patent ID CA2754787
Title Use of Atorvastatin Lactols As Medicaments.
Applicant(s) Bradford Pharma Ltd
Representative Drug(s) D09ZXW Drug Info N.A. [1]
Patent ID CA2826178
Title A Compound Separated From Monascus-Fermented Rice, The Preparation Method and Uses Thereof.
Representative Drug(s) D0M9ZW Drug Info N.A. [1]
Patent ID CA2664066
Title Products and Methods Using Soy Peptides To Lower Total and Ldl Cholesterol Levels.
Taiwan Intellectual Property Office (TIPO)
Patent ID TW201345920
Title Sterols Derivative, and Preparation Method and Purpose Thereof.
Applicant(s) Univ Beijing Peking Wbl Biotech Co Ltd
Representative Drug(s) D08FMC Drug Info N.A. [1]
References  Top
REF 1 HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015).Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272.

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