Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T68706 Target Info
Target Name Dibasic-processing enzyme (Furin)
Synonyms Paired basic amino acid residuecleaving enzyme; Paired basic amino acid residue-cleaving enzyme; PCSK3; PACE; FUR; Dibasicprocessing enzyme
Target Type Preclinical Target
Gene Name FURIN
Biochemical Class Peptidase
UniProt ID
FURIN_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
United States Patent and Trademark Office (USPTO)
Patent ID US9266828
Title Inhibitors of Furin and other pro-protein convertases
Abstract Disclosed herein are Furin/PC inhibitors for inhibiting Furin and other Propprotein Convertases. Method of making the Furin/PC inhibitors, chemical and biological characterization of the Furin/PC inhibitors, and the use of the Furin/PC inhibitors to treat infectious diseases, cancers, and inflammatory/autoimmune disorders, are also disclosed.
Applicant(s) SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
Representative Drug(s) D0W2BO Drug Info IC50 = 3.7 nM Click to Show More [1]
2 D0R9MA Drug Info IC50 = 9 nM [1]
3 D02QTG Drug Info IC50 = 300 nM [1]
Patent ID US9266828
Title Inhibitors of Furin and other pro-protein convertases
Abstract Disclosed herein are Furin/PC inhibitors for inhibiting Furin and other Propprotein Convertases. Method of making the Furin/PC inhibitors, chemical and biological characterization of the Furin/PC inhibitors, and the use of the Furin/PC inhibitors to treat infectious diseases, cancers, and inflammatory/autoimmune disorders, are also disclosed.
Applicant(s) SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
Representative Drug(s) D0W2BO Drug Info IC50 = 3.7 nM Click to Show More [1]
2 D0R9MA Drug Info IC50 = 9 nM [1]
3 D02QTG Drug Info IC50 = 300 nM [1]
Patent ID US9266828
Title Inhibitors of Furin and other pro-protein convertases
Abstract Disclosed herein are Furin/PC inhibitors for inhibiting Furin and other Propprotein Convertases. Method of making the Furin/PC inhibitors, chemical and biological characterization of the Furin/PC inhibitors, and the use of the Furin/PC inhibitors to treat infectious diseases, cancers, and inflammatory/autoimmune disorders, are also disclosed.
Applicant(s) SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
Representative Drug(s) D0W2BO Drug Info IC50 = 3.7 nM Click to Show More [1]
2 D0R9MA Drug Info IC50 = 9 nM [1]
3 D02QTG Drug Info IC50 = 300 nM [1]
References  Top
REF 1 Inhibitors of Furin and other pro-protein convertases. US9266828.

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