Target and Its Patented Drug(s)
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T76454 | Target Info | |||
| Target Name | Keap1-Nrf2[ETGE] PPI (KEAP1-Nrf2 ETGE) | ||||
| Synonyms | Kelch-like protein 19-Nrf2[ETGE]; Kelch-like ECH-associated protein 1-Nrf2[ETGE]; KLHL19-Nrf2[ETGE]; KIAA0132-Nrf2[ETGE]; INrf2-Nrf2[ETGE]; Cytosolic inhibitor of Nrf2-Nrf2[ETGE] | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | KEAP1-NFE2L2 | ||||
| UniProt ID | |||||
| Patent(s) and the Corresponding Patented Drug(s) | Top | ||||
|---|---|---|---|---|---|
| World Intellectual Property Organization (WIPO) | |||||
| Patent ID | WO2015092713 | ||||
| Title | Nrf2 Regulators. | ||||
| Abstract | The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators. | ||||
| Applicant(s) | Glaxosmithkline Intellectual Property Development Limited | ||||
| Representative Drug(s) | D0O6LW | Drug Info | IC50(fluorescence polarization) > 1000 nM | Click to Show More | [1] |
| 2 | D0MS7G | Drug Info | IC50(fluorescence polarization) = 61000 nM | [1] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. | ||||
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