| Patent(s) and the Corresponding Patented Drug(s) |
Top |
| World Intellectual Property Organization (WIPO) |
| Patent ID |
WO2012151319 |
| Title |
Cathepsin Inhibitors for The Treatment of Bone Cancer and Bone Cancer Pain. |
| Abstract |
The present invention is directed to methods of using compounds that are inhibitors of cysteine proteases, in particular, of both cathepsins S and K and optionally further cathepsins B and/or L in treating bone cancer. The present invention is directed to pharmaceutical compositions comprising these compounds for treating bone cancer and bone cancer pain, especially the pain associated with metastasis. A single compound can be used to ameliorate the pain, the injury to bone, while also reducing tumor growth, the risk of metastasis and/or invasiveness of the cancer. |
| Applicant(s) |
Virobay, Inc. Booth, Robert |
| Representative Drug(s) |
D06XCD |
Drug Info
|
IC50 = 4.7 nM |
[1] |
| Patent ID |
WO2010056877 |
| Title |
Preparation of Fluoroalkyl Amino Acid Amides As Inhibitors of Cathepsin B, K, L, F, or S. |
| Representative Drug(s) |
D05OIU |
Drug Info
|
Ki < 100 nM |
[1] |
| United States Patent and Trademark Office (USPTO) |
| Patent ID |
US8680152 |
| Title |
Cathepsin Inhibitors for The Treatment of Bone Cancer and Bone Cancer Pain. |
| Representative Drug(s) |
D06XCD |
Drug Info
|
IC50 = 4.7 nM |
[1] |
| Patent ID |
US20120282267 |
| Title |
Cathepsin Inhibitors for The Treatment of Bone Cancer and Bone Cancer Pain. |
| Representative Drug(s) |
D06XCD |
Drug Info
|
IC50 = 4.7 nM |
[1] |
| European Patent Office (EPO) |
| Patent ID |
EP2361243 |
| Title |
Preparation of Fluoroalkyl Amino Acid Amides As Inhibitors of Cathepsin B, K, L, F, or S. |
| Representative Drug(s) |
D05OIU |
Drug Info
|
Ki < 100 nM |
[1] |
| Japan Patent Office (JPO) |
| Patent ID |
JP5540004 |
| Title |
Preparation of Fluoroalkyl Amino Acid Amides As Inhibitors of Cathepsin B, K, L, F, or S. |
| Representative Drug(s) |
D05OIU |
Drug Info
|
Ki < 100 nM |
[1] |
| Patent ID |
JP2012508758 |
| Title |
Preparation of Fluoroalkyl Amino Acid Amides As Inhibitors of Cathepsin B, K, L, F, or S. |
| Representative Drug(s) |
D05OIU |
Drug Info
|
Ki < 100 nM |
[1] |
| China National Intellectual Property Administration (CNIPA) |
| Patent ID |
CN102264695 |
| Title |
Preparation of Fluoroalkyl Amino Acid Amides As Inhibitors of Cathepsin B, K, L, F, or S. |
| Representative Drug(s) |
D05OIU |
Drug Info
|
Ki < 100 nM |
[1] |
| Intellectual Property Office in India (IP India) |
| Patent ID |
IN2011KN02004 |
| Title |
Preparation of Fluoroalkyl Amino Acid Amides As Inhibitors of Cathepsin B, K, L, F, or S. |
| Representative Drug(s) |
D05OIU |
Drug Info
|
Ki < 100 nM |
[1] |
| Canadian Intellectual Property Office (CIPO) |
| Patent ID |
CA2743749 |
| Title |
Preparation of Fluoroalkyl Amino Acid Amides As Inhibitors of Cathepsin B, K, L, F, or S. |
| Representative Drug(s) |
D05OIU |
Drug Info
|
Ki < 100 nM |
[1] |
