Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T79570 Target Info
Target Name Aggrecanase-1 (ADAMTS4)
Synonyms Aggrecanase 1; ADMP-1; ADAMTS4; ADAM-TS4; ADAM-TS 4; A disintegrin and metalloproteinase with thrombospondin motifs 4
Target Type Patented-recorded Target
Gene Name ADAMTS4
Biochemical Class Peptidase
UniProt ID
ATS4_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
United States Patent and Trademark Office (USPTO)
Patent ID US9206139
Title Aggrecanase inhibitors
Abstract The present invention provides compounds having the formula: wherein R1 is selected from methyl, ethyl, propyl, cyclopropyl, and dimethyl, or a pharmaceutically acceptable salt thereof, along with methods and intermediates for their preparation, and uses thereof.
Applicant(s) Eli Lilly and Company
Representative Drug(s) D0G1LL Drug Info IC50 = 2 nM Click to Show More [1]
2 D0UM5R Drug Info IC50 = 7 nM [1]
3 D0N6ZA Drug Info IC50 = 14 nM [1]
Patent ID US9206139
Title Aggrecanase inhibitors
Abstract The present invention provides compounds having the formula: wherein R1 is selected from methyl, ethyl, propyl, cyclopropyl, and dimethyl, or a pharmaceutically acceptable salt thereof, along with methods and intermediates for their preparation, and uses thereof.
Applicant(s) Eli Lilly and Company
Representative Drug(s) D0G1LL Drug Info IC50 = 2 nM Click to Show More [1]
2 D0UM5R Drug Info IC50 = 7 nM [1]
3 D0N6ZA Drug Info IC50 = 14 nM [1]
Patent ID US9206139
Title Aggrecanase inhibitors
Abstract The present invention provides compounds having the formula: wherein R1 is selected from methyl, ethyl, propyl, cyclopropyl, and dimethyl, or a pharmaceutically acceptable salt thereof, along with methods and intermediates for their preparation, and uses thereof.
Applicant(s) Eli Lilly and Company
Representative Drug(s) D0G1LL Drug Info IC50 = 2 nM Click to Show More [1]
2 D0UM5R Drug Info IC50 = 7 nM [1]
3 D0N6ZA Drug Info IC50 = 14 nM [1]
References  Top
REF 1 Aggrecanase inhibitors. US9206139.

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