Patent(s) and the Corresponding Patented Drug(s) |
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World Intellectual Property Organization (WIPO) |
Patent ID |
WO2014107771 |
Title |
Substituted Indazole or Indole Derivatives As In Vitro Mao-B Inhibitors. |
Abstract |
Substituted indazole or imidazole derivatives of formula I as in vitro selective and reversible MAO-B inhibitors and for use in the prevention and treatment of meurodegenerative disorders such as Parkinson's disease, Alzheimer's disase and dementia. |
Applicant(s) |
Ntz Lab Ltd |
Representative Drug(s) |
D04FJY |
Drug Info
|
IC50 = 0.02 nM |
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[1] |
2
|
D01JDK
|
Drug Info
|
IC50 = 0.052 nM
|
[1] |
3
|
D0K2LB
|
Drug Info
|
IC50 = 0.23 nM
|
[1] |
4
|
D0Z6ZH
|
Drug Info
|
IC50 = 0.59 nM
|
[1] |
5
|
D0S2LV
|
Drug Info
|
IC50 = 0.61 nM
|
[1] |
6
|
D0AF7J
|
Drug Info
|
IC50 = 0.66 nM
|
[1] |
7
|
D00VSX
|
Drug Info
|
IC50 = 0.67 nM
|
[1] |
8
|
D06EIP
|
Drug Info
|
IC50 = 0.68 nM
|
[1] |
9
|
D0J3JY
|
Drug Info
|
IC50 = 1 nM
|
[1] |
10
|
D0UL2R
|
Drug Info
|
IC50 = 1.1 nM
|
[1] |
11
|
D0V2NC
|
Drug Info
|
IC50 = 1.4 nM
|
[1] |
12
|
D02FRR
|
Drug Info
|
IC50 = 1.5 nM
|
[1] |
13
|
D0B2YJ
|
Drug Info
|
IC50 = 1.6 nM
|
[1] |
14
|
D07GZU
|
Drug Info
|
IC50 = 1.9 nM
|
[1] |
15
|
D0HR6P
|
Drug Info
|
IC50 = 2.1 nM
|
[1] |
16
|
D08YYW
|
Drug Info
|
IC50 = 2.3 nM
|
[1] |
17
|
D0GY4F
|
Drug Info
|
IC50 = 2.8 nM
|
[1] |
18
|
D00YBT
|
Drug Info
|
IC50 = 3.4 nM
|
[1] |
19
|
D0Q1MN
|
Drug Info
|
IC50 = 4.4 nM
|
[1] |
20
|
D05UNM
|
Drug Info
|
IC50 = 5.4 nM
|
[1] |
21
|
D00KTI
|
Drug Info
|
IC50 = 8.1 nM
|
[1] |
22
|
D01PCI
|
Drug Info
|
IC50 = 38 nM
|
[1] |
23
|
D0DM9L
|
Drug Info
|
IC50 = 38 nM
|
[1] |
24
|
D06BFA
|
Drug Info
|
IC50 = 120 nM
|
[1] |
25
|
D0C2EW
|
Drug Info
|
IC50 = 190 nM
|
[1] |
Patent ID |
WO2012042042 |
Title |
Selective Lsd1 and Dual Lsd1/Mao-B Inhibitors for Modulating Diseases Associated with Alterations In Protein Conformation. |
Abstract |
The invention relates to methods and compositions for the treatment or prevention of protein conformation disorders. In particular, the invention relates to an LSD1 inhibitor for use in treating or preventing a protein conformation disorder, such as, e.g., Huntington Disease. |
Applicant(s) |
Oryzon Genomics, Sa |
Representative Drug(s) |
D02WXS |
Drug Info
|
IC50 < 200 nM |
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[1] |
2
|
D0E7SF
|
Drug Info
|
IC50 < 200 nM
|
[1] |
3
|
D06KBT
|
Drug Info
|
IC50 < 300 nM
|
[1] |
4
|
D0IO2A
|
Drug Info
|
IC50 = 600 nM
|
[1] |
5
|
D0AI6J
|
Drug Info
|
IC50 = 1000 to 3000 nM
|
[1] |
6
|
D0Q1EG
|
Drug Info
|
IC50 = 1000 to 5000 nM
|
[1] |
7
|
D0PM2S
|
Drug Info
|
IC50 > 40000 nM
|
[1] |
8
|
D06VMN
|
Drug Info
|
N.A.
|
[1] |
Patent ID |
WO2014079964 |
Title |
Frozen Confection. |
Abstract |
A frozen confection comprising from 0.002 wt% to 1 wt% of one or more compounds selected from the group consisting of benzyl cinnamate, piperonal, 4-methoxybenzaldehyde, and 4-hydroxybenzaldehyde is provided. A product for use in improving mood is also provided. |
Applicant(s) |
Unilever Plc Unilever Nv Conopco, Inc., D / B / A Unilever |
Representative Drug(s) |
D00BRD |
Drug Info
|
N.A. |
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[1] |
2
|
D00NDF
|
Drug Info
|
N.A.
|
[1] |
3
|
D03SLR
|
Drug Info
|
N.A.
|
[1] |
4
|
D03VOJ
|
Drug Info
|
N.A.
|
[1] |
5
|
D03ZOH
|
Drug Info
|
N.A.
|
[1] |
6
|
D09SWE
|
Drug Info
|
N.A.
|
[1] |
7
|
D0B5YS
|
Drug Info
|
N.A.
|
[1] |
8
|
D0BT3Y
|
Drug Info
|
N.A.
|
[1] |
9
|
D0ME4N
|
Drug Info
|
N.A.
|
[1] |
10
|
D0N3SU
|
Drug Info
|
N.A.
|
[1] |
11
|
D0N9JJ
|
Drug Info
|
N.A.
|
[1] |
12
|
D0NH9P
|
Drug Info
|
N.A.
|
[1] |
13
|
D0O4QB
|
Drug Info
|
N.A.
|
[1] |
14
|
D0TR7N
|
Drug Info
|
N.A.
|
[1] |
15
|
D0UA3V
|
Drug Info
|
N.A.
|
[1] |
16
|
D0X7BT
|
Drug Info
|
N.A.
|
[1] |
17
|
D0XV2A
|
Drug Info
|
N.A.
|
[1] |
Patent ID |
WO2011106105 |
Title |
Inhibitors for Antiviral Use. |
Abstract |
The present invention relates to the use of potent selective LSD1 inhibitors and LSD1/MAO-B inhibitors for treating or preventing viral infections. Furthermore, the present invention relates to the new use of cyclopropylamine acetamide derivatives or cyclopropylamine derivatives, as defined herein, for treating or preventing viral infection and treating or preventing reactivation of a virus after latency. |
Applicant(s) |
Oryzon Genomics, Sa |
United States Patent and Trademark Office (USPTO) |
Patent ID |
US20140186280 |
Title |
Neuroprotective and Neurorestorative Iron Chelators and Monoamine Oxidase Inhibitors and Uses Thereof. |
Applicant(s) |
Varinel, Inc |
Patent ID |
US20140315944 |
Title |
Substituted Naphthyridine and Quinoline Compounds As Mao Inhibitors. |
Applicant(s) |
Dart Neuroscience, Llc |
Patent ID |
US20100324147 |
Title |
Trans-2-Arylcyclopropylamine Derivatives As Inhibitors of Lysine-Specific Demethylase 1, Monoamine Oxidase A and B, and Their Preparation and Use for The Treatment of Cancer. |
Applicant(s) |
Duke University, Usa |
China National Intellectual Property Administration (CNIPA) |
Patent ID |
CN105017195 |
Title |
4-Hydroxycoumarin-3-Schiff Base Derivate and Use Thereof for Curing AlzheimerS Disease. |
Applicant(s) |
University China Pharma |
Representative Drug(s) |
D05RJG |
Drug Info
|
IC50 = 711 nM |
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[3] |
2
|
D0DW5P
|
Drug Info
|
IC50 = 851 nM
|
[3] |
Patent ID |
CN104892556 |
Title |
Stilbene Coumarin Derivative As Well As Preparation Method and Application Thereof. |
Applicant(s) |
University Hefei Technology |
Representative Drug(s) |
D0L9FL |
Drug Info
|
IC50 = 2780 nM |
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[3] |
2
|
D0Z5VD
|
Drug Info
|
IC50 = 3200 nM
|
[3] |
Patent ID |
CN105153195 |
Title |
Tricyclo-Pyrazole [1,5-D] [1,4] Benzo Oxazepine-One Derivatives and Preparation Method and Application Thereof. |
Representative Drug(s) |
D07UZL |
Drug Info
|
IC50 = 1210 nM |
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[3] |
2
|
D04OXC
|
Drug Info
|
IC50 = 1890 nM
|
[3] |
Patent ID |
CN106588847 |
Title |
Dihydrocoumarin Derivatives As Well As Preparation Method and Application Thereof. |
Applicant(s) |
SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE |
Patent ID |
CN105601563 |
Title |
6-Chloro-N-(4-(6-Chloro-Nicotinamide)Benzyl) Nicotinamide, and Preparation and Application Thereof. |
Applicant(s) |
University Zhejiang Technology |
Representative Drug(s) |
D0C7LB |
Drug Info
|
IC50 = 44 nM |
[3] |
Patent ID |
CN105534964 |
Title |
Application of Substituted Aryl Amides, or Nitrogen-Containing Heterocyclic Compounds In Manufacture of Monoamine Oxidase Inhibitor. |
Applicant(s) |
University Zhejiang Technology |
Representative Drug(s) |
D0J7HR |
Drug Info
|
IC50 = 35880 nM |
[3] |
Patent ID |
CN105503840 |
Title |
Tacrine-Coumarin Derivative Containing Triazole and Application of Derivative. |
Applicant(s) |
University Guangdong Technology |
Representative Drug(s) |
D0T9JB |
Drug Info
|
IC50 = 180 nM |
[3] |
Korean Intellectual Property Office (KIPO) |
Patent ID |
KR20120089882 |
Title |
Composition Comprising The Extract of Loranthus Yadoriki Sieb. Having Monoamine Oxidase-Inhibiting Activity. |
Applicant(s) |
Nat Arboretum Korea Forest Service |
Intellectual Property Office of Australia (IP Australia) |
Patent ID |
AU2014202864 |
Title |
Therapeutic Isoxazole Compounds. |
Applicant(s) |
Helicon Therapeutics |