Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T92609 Target Info
Target Name Adrenergic receptor alpha-1A (ADRA1A)
Synonyms Alpha-adrenergic receptor 1c; Alpha-1C adrenergic receptor; Alpha-1A adrenoreceptor; Alpha-1A adrenoceptor; Alpha-1A adrenergic receptor; Alpha adrenergic receptor 1c; Alpha 1A-adrenoreceptor; Alpha 1A-adrenoceptor; ADRA1C
Target Type Successful Target
Gene Name ADRA1A
Biochemical Class GPCR rhodopsin
UniProt ID
ADA1A_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
World Intellectual Property Organization (WIPO)
Patent ID WO2013102249
Title N-Phenylpiperazine Derivatives That Are Antagonists of 1A, 1D Adrenoceptors and 5-Ht1A Receptors for The Treatment of Benign Prostate Hyperplasia.
Abstract The present invention provided N-phenylpiperazine derivatives for use as multiple binders and/or antagonists of alpha1A adrenoceptors, alpha1D adrenoceptors and 5-HT1A serotonin receptors. These substances are candidates to prototypes for the treatment of benign prostate hyperplasia and lower urinary tract symptoms, and are useful in pharmaceutical compositions.
Applicant(s) Univ Rio De Janeiro
Representative Drug(s) D0EO8F Drug Info Ki = 3.76 nM [1]
United States Patent and Trademark Office (USPTO)
Patent ID US20150011566
Title N-Phenylpiperazine Derivatives That Are Antagonists of A1A, A1D Adrenoreceptors and 5-Ht1A Receptors for The Treatment of Benign Prostate Hyperplasia.
Representative Drug(s) D0EO8F Drug Info Ki = 3.76 nM Click to Show More [1]
2 D0SG8X Drug Info Ki = 46 nM [1]
References  Top
REF 1 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689.

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