Prodrug Information
| Prodrug General Information | Top | |||||
|---|---|---|---|---|---|---|
| Prodrug ID |
D92HMR
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| Prodrug Name |
PMID26729077-Compound-5
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| Indication | Herpes simplex virus infection [ICD-11: 1F00; ICD-10: B00; ICD-9: 54] | Investigative | [1] | |||
| Activation |
Prodrug 
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Parent Drug 
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| 2D MOL 3D MOL | ||||||
| [1] | ||||||
| Prodrug Strategy |
Classical prodrug strategy
[Carrier linked prodrug]
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| Improved property |
Increase solubility
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[1] | ||||
| Description |
PMID26729077-Compound-5 shows 4000-fold greater solubility in water and 7-15 fold greater bioavailability compared to the parent drug.
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[1] | ||||
| Parent Drug General Information | Top | |||||
|---|---|---|---|---|---|---|
| Parent Drug ID |
DL0X1V
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| Parent Drug Name |
Cf1743
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| Synonyms |
CF-1743; UNII-5XGI48Q2DH; 319425-66-6; 5XGI48Q2DH; 3-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-2(3H)-one; CHEMBL344738; SCHEMBL17709503; DTXSID60185781; BDBM50481116
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| Formula |
C22H26N2O5
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| Canonical SMILES |
CCCCCC1=CC=C(C=C1)C2=CC3=CN(C(=O)N=C3O2)[C@H]4C[C@@H]([C@H](O4)CO)O
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| InChI |
1S/C22H26N2O5/c1-2-3-4-5-14-6-8-15(9-7-14)18-10-16-12-24(22(27)23-21(16)29-18)20-11-17(26)19(13-25)28-20/h6-10,12,17,19-20,25-26H,2-5,11,13H2,1H3/t17-,19+,20+/m0/s1
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| InChIKey |
MFGSDSRTGUVZQG-DFQSSKMNSA-N
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| CAS Number |
CAS 319425-66-6
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| PubChem Compound ID | ||||||
| References | Top | |||||
|---|---|---|---|---|---|---|
| REF 1 | Dipeptidyl peptidase IV dependent water-soluble prodrugs of highly lipophilic bicyclic nucleoside analogues. J Med Chem. 2011 Mar 24;54(6):1927-42. | |||||
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