Prodrug Information
Prodrug General Information | Top | |||||
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Prodrug ID |
DZ1W3J
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Prodrug Name |
Fospropofol disodium
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Synonyms |
5-fluoropyridine-2,3-diamine; 212268-13-8; 2,3-Diamino-5-fluoropyridine; 5-fluoro-2,3-pyridinediamine; 2,3-Pyridinediamine, 5-fluoro-; 2,3-DIAMINO-5-FLUORO-PYRIDINE; 5-fluoro-2,3-diaminopyridine; PubChem5390; SCHEMBL1198418; CTK7C2738; DTXSID70624479; 0824AB; ANW-61786; MFCD08062986; ZINC21981774; AKOS006286219; GS-5024; QC-7121; AK-28980; SC-49813; AB0070663; DB-003060; CS-0039113; FT-0649159; A815208; J-013935; J-517553
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Indication | Anaesthesia [ICD-11: 9A78.6] | Approved | [1] | |||
Activation |
Prodrug |
Parent Drug |
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2D MOL 3D MOL | 2D MOL 3D MOL | |||||
(1) Bioconversion Enzyme:
Alkaline phosphatase
(EC 3.1)
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[2] | |||||
Prodrug Strategy |
Classical prodrug strategy
[Carrier linked prodrug]
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Improved property |
Increase solubility
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Description |
Fospropofol is water soluble and can be administered in an aqueous solution which is unlike propofol.
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Formula |
C5H6FN3
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Canonical SMILES |
C1=C(C=NC(=C1N)N)F
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InChI |
1S/C5H6FN3/c6-3-1-4(7)5(8)9-2-3/h1-2H,7H2,(H2,8,9)
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InChIKey |
MGBUJACQIBNLAU-UHFFFAOYSA-N
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CAS Number |
CAS 212268-13-8
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PubChem Compound ID |
Parent Drug General Information | Top | |||||
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Parent Drug ID |
DT7XU4
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Parent Drug Name |
Propofol
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Synonyms |
Pofol; Propofol; Propofol IDD-D; Propofol(2,6-Diisopropylphenol); Propofol-Lipuro; Propofolum; Propovan; Propoven; Rapinovet; Recofol; VZ22957; ZD-0859; 2, 6-Diisopropylphenol; 2, 6-bis(1-methylethyl)-Phenol; 2,6 Diisopropylphenol; 2,6-Bis(1-methylethyl)phenol; 2,6-DIISOPROPYLPHENOL; 2,6-Diisopropyl phenol; 2,6-bis(1-methylethyl)-Phenol; 2,6-bis(Isopropyl)phenol; 2,6-bis(methylethyl)phenol; 2,6-bis(propan-2-yl)phenol; 2,6-di isopropyl phenol; 2,6-di(propan-2-yl)phenol; 2,6-diisopropyl-phenol; 6-bis(1-methylethyl)-Phenol; 6-diisopropyl-Phenol; Ampofol; Aquafo; Aquafol; CHEMBL526; D0617; D126608; DDS-04F; Diisopropylphenol; Diisopropylphenol (Related); Dipravan; Diprifusor; Diprivan; Diprivan 10; Diprofol; Disoprivan; Disoprofol; Fresofol; Ivofol; MLS-0318084;
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Formula |
C12H18O
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Canonical SMILES |
CC(C)C1=C(C(=CC=C1)C(C)C)O
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InChI |
1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3
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InChIKey |
OLBCVFGFOZPWHH-UHFFFAOYSA-N
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CAS Number |
CAS 2078-54-8
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PubChem Compound ID | ||||||
ChEBI ID |
CHEBI:44915
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References | Top | |||||
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REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2010 | |||||
REF 2 | Fospropofol disodium, a water-soluble prodrug of the intravenous anesthetic propofol (2,6-diisopropylphenol). Expert Opin Investig Drugs. 2009 Oct;18(10):1565-71. | |||||
REF 3 | Fospropofol: clinical pharmacology. J Anaesthesiol Clin Pharmacol. 2011 Jan;27(1):79-83. | |||||
REF 4 | The prodrug approach in the era of drug design. Expert Opin Drug Deliv. 2019 Jan;16(1):1-5. |
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