Target Poor or Non Binder(s) Information

Target General Information

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Target ID

T00895

Target Info

Target Name

Protein kinase C epsilon (PRKCE)

Synonyms

Protein kinase C epsilon type; PKCE; PKC epsilon; NPKC-epsilon

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Target Type

Successful Target

Gene Name

PRKCE

Biochemical Class

Kinase

UniProt ID

Q02156

Poor Binders of This Target (in total, 33 binders)

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Compound Name

Zidovudine

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Approved

Compound Info

Synonyms

zidovudine; Azidothymidine; 30516-87-1; 3'-Azido-3'-deoxythymidine; Retrovir; AZT; Zidovudinum; Compound S; Thymidine, 3'-azido-3'-deoxy-; ZIDOVUDINE [AZT]; zidovudin; BW A509U; Zidovudinum [Latin]; Zidovudina [Spanish]; BWA509U; DRG-0004; 3'-Azido-2',3'-Dideoxythymidine; ZDV; UNII-4B9XT59T7S; 3'-Deoxy-3'-azidothymidine; CCRIS 105; Aztec; BW-A509U; BW-A-509U; HSDB 6515; 3'-Azido-3'-deoxythymidine (AIDS); CHEMBL129; NSC 602670; BW-A 509U; MLS000028548; 4B9XT59T7S; AZT; Antiviral; Azidodeoxythymidine; ZVD; Zidovudin; Zidovudina; AZT Antiviral; AZT TRANSPLACENTAL CARCINOGENESIS STUDY; Antiviral AZT; Cpd S; Racemic Liposomal AZT; Zidovudine EP III; BWA 509U; K7 [P Ti2 W10 O40]; AZT & EPO; AZT & HPA; AZT & Lymphoblastoid Interferon; AZT & SST; AZT & rsT4; AZT & sCD4; AZT & srCD4; AZT (Antiviral); AZT+PRO 140; AZT, Antiviral; Apo-Zidovudine; BWA-509U; Intron A & AZT; Novo-Azt; Propolis+AZT; Retrovir (TN); Retrovir(TM); Retrovis (TN); Zidovudine+PRO 140; AZT & Colony-stimulating factor 2; AZT & Concanavalin A (ConA); AZT & GM-CSF; AZT & IFN-alpha; AZT & IL-1; AZT & IL-2; AZT & IL-6; AZT & Li & EPO; AZT & NP (from PHCA or HSA); AZT & PM-19; DS-4152 & AZT; Liposomal AZT-SN-1; Liposomal AZT-SN-3; PC-SOD+AZT;RIFN-beta seron & AZT; AZT & CD4(178)-PE 40; AZT & Li & GM-CSF; AZT & Li & IL-1; AZT & Li & IL-6; AZT & rIFNalpha2; Racemic-dipalmitoylglycerophospho-AZT (in a lipid vesicle); Zidovudine (JAN/USP/INN); Zidovudine [USAN:INN:BAN:JAN]; AZT & rsCD4 & rIFNalphaA; SN-1-dipalmitoylglycerophospho-AZT (in a lipid vesicle); SN-3-dipalmitoylglycerophospho-AZT (in a lipid vesicle); AZT & Interferon-alpha-2; Met-SDF-1beta & AZT; Met-SDF-1beta & Zidovudine; Interferon AD + 3'-azido-3'-deoxythymidine; 1-(3-Azido-2,3-dideoxy-beta-D-ribofuranosyl)thymine; 3′-Azido-3′-deoxythymidine; 3' Azido 2',3' Dideoxythymidine; 3' Azido 3' deoxythymidine; 3'-Azido-3'-deoxythymidine & Concanavalin A; 3'-Azido-3'-deoxythymidine & Erythropoietin; 3'-Azido-3'-deoxythymidine & Heteropolyoxotungstate PM-19; 3'-Azido-3'-deoxythymidine & Interleukin-1; 3'-Azido-3'-deoxythymidine & Interleukin-2; 3'-Azido-3'-deoxythymidine & Interleukin-6; 3'-Azido-3'-deoxythymidine & Lithium & Erythropoietin; 3'-Azido-3'-deoxythymidine & Lithium & Interleukin-1; 3'-Azido-3'-deoxythymidine & Lithium & Interleukin-6; 3'-Azido-3'-deoxythymidine & Lymphoblastoid Interferon; 3'-Azido-3'-deoxythymidine & Sho-Saiko-To; 3'-Azido-3'deoxythymidine & Interferon-alpha; 3'-Azidothymidine; 3'-azido-3'-deoxythymidine, AZT; 3-Azido-3-deoxythymidine; Dendrigen; CTCE-0422

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Activity

IC50 ~ 150000 nM

[1]

Compound Name

BETULINIC ACID

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Phase 1

Compound Info

Synonyms

betulinic acid; 472-15-1; Mairin; Betulic acid; NSC 113090; CCRIS 6748; 3-Hydroxylup-20(29)-en-28-oic acid; UNII-4G6A18707N; 3beta-Hydroxy-20(29)-lupaene-28-oic acid; EINECS 207-448-8; NSC677578; als-357; NSC 677578; CHEMBL269277; CHEBI:3087; 3beta-Hydroxy-lup-20(29)-en-28-oic acid; 4G6A18707N; Lup-20(29)-en-28-oic acid, 3-hydroxy-, (3beta)-; AK-72848; Lupatic Acid; SMR000445624

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Activity

IC50 ~ 150000 nM

[1]

Compound Name

L-751250

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Preclinical

Compound Info

Synonyms

Purvalanol B; 212844-54-7; PURVALANOL; Purvalanol B(NG-95); (R)-2-chloro-4-((2-((1-hydroxy-3-methylbutan-2-yl)amino)-9-isopropyl-9H-purin-6-yl)amino)benzoic acid; (2R)-2-[[6-[(3-CHLORO-4-CARBOXYPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL; CHEMBL23254; CHEBI:49840; NG 95; NG-95; C20H25ClN6O3; 2-chloro-4-[[2-[[(2R)-1-hydroxy-3-methylbutan-2-yl]amino]-9-propan-2-ylpurin-6-yl]amino]benzoic acid; J-502183; PVB

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Activity

IC50 ~ 100000 nM

[2]

Compound Name

aloisine A

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Investigative

Compound Info

Synonyms

ALOISINE A; 4-(7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol; 496864-16-5; RP107; 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE; CHEMBL75680; 7-n-Butyl-6-(4-hydroxyphenyl)[5H]pyrrolo[2,3-b]pyrazine; RP-107; ALH; 4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol; 1ung; SCHEMBL80147; BDBM7377; GTPL5924; AC1NS169; 4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)-phenol; CHEBI:93641; CTK8D4068; DTXSID30416115; HMS3229A14; RM-39; BCP26893; ZINC2540737; ACT06534; IN1539; HSCI1_000219; MFCD04973541; AKOS005145972; CCG-206814; DB07364; RTC-063070; AJ-39131

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Activity

IC50 ~ 100000 nM

[3]

Compound Name

BETULIN

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Investigative

Compound Info

Synonyms

Betulin; 473-98-3; Betulinol; Betuline; Trochol; Lup-20(29)-ene-3b,28-diol; Betulol; Lup-20(29)-ene-3beta,28-diol; UNII-6W70HN7X7O; NSC 4644; C30H50O2; EINECS 207-475-5; Lup-20(30)-ene-3beta,28-diol; AI3-62999; CHEBI:3086; 6W70HN7X7O; Lup-20(29)-ene-3,28-diol, (3beta)-; (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-(Hydroxymethyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-ol; Betulinic alcohol; lup-20(29)-ene-3 beta,28-diol

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Activity

IC50 ~ 150000 nM

[1]

Compound Name

3-Hydroxy-2-[4-[2-[(4-hydroxybenzoyl)amino]cyclopentyl]oxycarbonyl-2,6-dimethylbenzoyl]benzoic acid

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Investigative

Compound Info

Synonyms

CHEMBL87075

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Activity

IC50 ~ 50000 nM

[4]

Compound Name

2-(2,6-Dihydroxy-4-{[(1S,2R)-2-(4-hydroxy-benzoylamino)-cyclopentylmethyl]-carbamoyl}-benzoyl)-3-hydroxy-benzoic acid

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Investigative

Compound Info

Synonyms

CHEMBL293500; BDBM50285092

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Activity

IC50 ~ 50000 nM

[5]

Compound Name

2-[2,6-Dihydroxy-4-[[(3R,4S)-3-[(4-hydroxybenzoyl)amino]azepan-4-yl]-methylcarbamoyl]benzoyl]-3-hydroxybenzoic acid

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Investigative

Compound Info

Synonyms

CHEMBL2310935; BDBM50450311

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Activity

IC50 ~ 50000 nM

[5]

Compound Name

Acyclic Balanol Analog 8b

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Investigative

Compound Info

Synonyms

BDBM3190; CHEMBL343362

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Activity

IC50 ~ 50000 nM

[6]

Compound Name

[2-[(4-Hydroxybenzoyl)amino]cyclopentyl] 3,5-dihydroxy-4-(8-hydroxy-4-oxo-3H-phthalazin-1-yl)benzoate

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Investigative

Compound Info

Synonyms

CHEMBL313902

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Activity

IC50 ~ 50000 nM

[4]

Compound Name

Modified Benzophenone Carboxylic Acid, Balanol Analog 37

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Investigative

Compound Info

Synonyms

CHEMBL55890; BDBM3237

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Activity

IC50 ~ 50000 nM

[7]

Compound Name

3-Hydroxy-2-[4-[4-[(4-hydroxybenzoyl)amino]pyrrolidin-3-yl]oxycarbonylphenyl]benzoic acid

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Investigative

Compound Info

Synonyms

CHEMBL85129

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Activity

IC50 ~ 50000 nM

[4]

Compound Name

Acyclic Balanol Analog 7b

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Investigative

Compound Info

Synonyms

BDBM3188; CHEMBL149604

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Activity

IC50 ~ 50000 nM

[6]

Compound Name

Acyclic Balanol Analog 13b

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Investigative

Compound Info

Synonyms

BDBM3196; CHEMBL150422

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Activity

IC50 ~ 50000 nM

[6]

Compound Name

4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (1R,2R)-1-(4-hydroxy-benzoylamino)-indan-2-yl ester

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Investigative

Compound Info

Synonyms

CHEMBL444877; BDBM50289209

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Activity

IC50 ~ 50000 nM

[8]

Compound Name

Acyclic Balanol Analog 17b

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Investigative

Compound Info

Synonyms

BDBM3194; CHEMBL151731

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Activity

IC50 ~ 50000 nM

[6]

Compound Name

(18S)-18-[(Benzylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8,10,12,22,24,26-nonaene-3,5-dione

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Investigative

Compound Info

Synonyms

CHEMBL328229; BDBM50052040

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Activity

IC50 = 57000 nM

[9]

Compound Name

2-(2-((Dimethylamino)methyl)-5-methoxyphenyl)-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitrile

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Investigative

Compound Info

Synonyms

CHEMBL479835; SCHEMBL5532107; BDBM50255367

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Activity

IC50 = 95000 nM

[10]

Compound Name

(1S)-2-[2,6-Dihydroxy-4-[(4R)-3-[(4-hydroxybenzoyl)amino]azepan-4-yl]oxycarbonylbenzoyl]cyclohexane-1-carboxylic acid

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Investigative

Compound Info

Synonyms

CHEMBL88848

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Activity

IC50 = 97000 nM

[4]

Compound Name

1-(Tert-Butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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Investigative

Compound Info

Synonyms

1-NAPHTHYL PP1; 1-NA-PP1; pp1 analog; 4-Amino-1-tert-butyl-3-(1'-naphthyl)pyrazolo[3,4-d]pyrimidine; 1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 1-tert-butyl-3-naphthalen-1-ylpyrazolo[3,4-d]pyrimidin-4-amine; CHEMBL264406; 1-tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; C19H19N5; 1-tert-butyl-3-naphthalen-1-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 1-tert-butyl-3-naphthalen-1-yl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine; 1-Na PP1; 1-NaphthylPP1; NA-PP1; K00047; SCHEMBL173288; 1-NA-PP 1; CTK4E8691; 1-Naphthyl PP1(1-NA-PP1); DTXSID00274446; EX-A867; HMS3266C18; HMS3413H14; HMS3677H14; PP1-AG1872; BCP09108; ZINC2576349; 3272AH; 4-Amino-1-tert-butyl-3-(1'naphthyl)pyrazolo[3,4-d]pyrimidine; BDBM50229961; MFCD03425471; QC-203; s2642; AKOS024457409; ACN-046104; CS-1804; MB02817; KS-00001D85; NCGC00262627-06; AS-56537; HY-13941; AB0094864; PP1 Analog - CAS 221243-82-9; FT-0661645; A13232; InSolution PP1 Analog - CAS 221243-82-9; 425B471; W-201916; BRD-K29542628-001-01-3; Q27123369; 1-t-butyl-3-naphthalen-1-yl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine; 4-Amino-1-tert-butyl-3-(1''-naphthyl)pyrazolo[3,4-d]pyrimidine; 4-Amino-1-tert-butyl-3-(1?-naphthyl)pyrazolo[3,4-d]pyrimidine; 1-(tert-butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (4); 1H-pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine,1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-

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Activity

IC50 ~ 100000 nM

[11]

Compound Name

Acetic acid, methoxy-, 2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl ester

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Investigative

Compound Info

Synonyms

CHEMBL7600; BDBM6609; DTXSID60349381; Bis(1H-2-indolyl)methanone deriv. 67; [2-(1H-2-Indolylcarbonyl)-1H-5-indolyl]methoxyethanoate; 2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl 2-methoxyacetate; Methoxyacetic acid 2-(1H-indole-2-ylcarbonyl)-1H-indole-5-yl ester; Acetic acid, methoxy-, 2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl ester (9CI)

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Activity

IC50 ~ 100000 nM

[12]

Compound Name

Purvalanol A

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Investigative

Compound Info

Synonyms

2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine; 6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine; CHEMBL23327; UNII-YP483E75C4; NG-60; NG 60; YP483E75C4; MFCD02179211; (2R)-2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]-3-methylbutan-1-ol; C19H25ClN6O; Tocris-1580; Purvalanol A(NG 60); Lopac-P-4484; MLS006010846; SCHEMBL1217069; BCBcMAP01_000180; BDBM27216; AOB6163; DTXSID30175553; EX-A648; 2,6,9-Trisubstitute purine, 1; 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropyl-purine; HMS3268E19; HMS3412L07; HMS3676L07; ZINC582575; BCP06309; 3983AH; HY-18299A; s7793; AKOS022185058; CCG-101285; CS-4001; DB04751; SMP1_000251; NCGC00015814-01; NCGC00025219-01; NCGC00025219-02; NCGC00025219-04; NCGC00025219-10; Purvalanol A, >=98% (HPLC), powder; Purvalanol A - CAS 212844-53-6; SMR004701771; J-013971; BRD-K50836978-001-01-7; Q27464217; (2R)-2-[[6-(3-chloroanilino)-9-isopropyl-purin-2-yl]amino]-3-methyl-butan-1-ol; 6-(3-CHLOROANILINO)-2(1R)-ISOPROPYL-2-HYDROXYETHYLAMINO-9-ISOPROPYLPURINE

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Activity

IC50 ~ 100000 nM

[2]

Compound Name

[2-(1H-Indole-2-carbonyl)-1H-indol-5-yl] acetate

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Investigative

Compound Info

Synonyms

Bis(1H-2-indolyl)methanone deriv. 50; CHEMBL7572; BDBM6592; [2-(1H-2-indolylcarbonyl)-1H-5-indolyl]ethanoate; 2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl acetate; Acetic acid 2-(1H-indole-2-ylcarbonyl)-1H-indole-5-yl ester

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Activity

IC50 ~ 100000 nM

[12]

Compound Name

Platanic acid

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Investigative

Compound Info

Synonyms

CHEMBL80460; 3beta-Hydroxy-20-oxo-30-norlupan-28-oic acid; SCHEMBL15918102; DTXSID30976042; BDBM50103962; ZINC26472270; 3-Hydroxy-20-oxonorlupan-28-oic acid, (3.beta.); Q27133930; 30-Norlupan-28-oic acid, 3-hydroxy-20-oxo-, (3beta)-

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Activity

IC50 ~ 150000 nM

[1]

Compound Name

Betulinic acid 28-O-carboxymethylmethylate

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Investigative

Compound Info

Synonyms

CHEMBL509422; BDBM50292434

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Activity

IC50 ~ 150000 nM

[1]

Compound Name

Betulinic acid 3-O-sulfonate potassium salt

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Investigative

Compound Info

Synonyms

CHEMBL502585

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Activity

IC50 ~ 150000 nM

[1]

Compound Name

[(4R)-3-[(4-Hydroxybenzoyl)amino]azepan-4-yl] 3,5-dihydroxy-4-(1-hydroxynaphthalene-2-carbonyl)benzoate

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Investigative

Compound Info

Synonyms

CHEMBL91412

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Activity

IC50 ~ 150000 nM

[4]

Compound Name

Betulinic acid 3-O-succinate

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Investigative

Compound Info

Synonyms

CHEMBL446317; 3-O-Succinyl-betulinic Acid; SCHEMBL7533551; BDBM50292431; ZINC44306705; AKOS016036379; 3beta-(3-Carboxypropionyloxy)lupa-20(29)-ene-28-oic acid

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Activity

IC50 ~ 150000 nM

[1]

Compound Name

Betulinic acid 3-O-crotonate

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Investigative

Compound Info

Synonyms

CHEMBL448637; SCHEMBL7377372; BDBM50292435

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Activity

IC50 ~ 150000 nM

[1]

Compound Name

(1S,3As,5aR,5bR,9S,11aR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-propan-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid

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Investigative

Compound Info

Synonyms

CHEMBL108505; SCHEMBL14086957

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Activity

IC50 ~ 150000 nM

[1]

Compound Name

2-(N-[2,6-Dihydroxy-4-[4-[(4-hydroxybenzoyl)amino]pyrrolidin-3-yl]oxycarbonylbenzoyl]anilino)acetic acid

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Investigative

Compound Info

Synonyms

CHEMBL88962

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Activity

IC50 ~ 150000 nM

[4]

Compound Name

Betulinic acid 3-O-benzoate

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Investigative

Compound Info

Synonyms

CHEMBL509553; BDBM50292432; 3beta-(Benzoyloxy)lupa-20(29)-ene-28-oic acid

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Activity

IC50 ~ 150000 nM

[1]

Compound Name

3beta-Acetoxybetulinic acid

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Investigative

Compound Info

Synonyms

3-acetylbetulinic acid; 3-O-Acetyl-betulinic acid; 3-O-Acetyl Betulinic Acid; Betulinic Acid 3-O-Acetate; (3-O-Acetyl)Betulinic Acid; CHEMBL312687; Acetobetulinic acid; SCHEMBL962020; BDBM50103967; ZINC26484027; 3beta-acetoxylup-20(29)-en-28-oic acid; Lup-20(29)-en-28-oic acid, 3-(acetyloxy)-, (3b)-

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Activity

IC50 ~ 150000 nM

[1]

Click to Show/Hide the Information of All Poor Binders

Non Binders of This Target (in total, 1 non binders)

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Compound Name

4-Phenyl-[1]benzofuro[2,3-b]pyridine-3,6-diol

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Investigative

Compound Info

Synonyms

CHEMBL2163772; BDBM50395892

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Activity

Ki > 1000000 nM

[13]

References

Top

REF 1

Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids. J Nat Prod. 1994 Feb;57(2):243-7.

REF 2

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281(5376):533-8.

REF 3

Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. J Med Chem. 2003 Jan 16;46(2):222-36.

REF 4

Synthesis and protein kinase inhibitory activity of balanol analogues with modified benzophenone subunits. J Med Chem. 2002 Jun 6;45(12):2624-43.

REF 5

Novel PKC inhibitory analogs of balanol with replacement of the ester functionality. Bioorg Med Chem Lett. 1995 Sep 7;5(17):2015-20.

REF 6

Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. J Med Chem. 1996 Dec 20;39(26):5215-27.

REF 7

Protein kinase C inhibitory activities of balanol analogs bearing carboxylic acid replacements. Bioorg Med Chem Lett. 1995 Aug 17;5(16):1839-42.

REF 8

Synthesis and protein kinase C inhibitory activities of indane analogs of balanol. Bioorg Med Chem Lett. 1996 Apr 23;6(8):973-8.

REF 9

(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H... J Med Chem. 1996 Jul 5;39(14):2664-71.

REF 10

Second generation 4-(4-methyl-1H-indol-5-ylamino)-2-phenylthieno[2,3-b]pyridine-5-carbonitrile PKCtheta inhibitors. Bioorg Med Chem Lett. 2009 Feb 1;19(3):766-9.

REF 11

Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2... J Biol Chem. 2007 Nov 9;282(45):33052-63.

REF 12

Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase. J Med Chem. 2002 Feb 28;45(5):1002-18.

REF 13

Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases. Bioorg Med Chem Lett. 2012 Nov 15;22(22):6914-8.

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