Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T02752 | Target Info | |||
| Target Name | C-C chemokine receptor type 3 (CCR3) | ||||
| Synonyms |
Eosinophil eotaxin receptor; Chemokine receptor CCR3; CMKBR3; CKR3; CD193; CCR-3; CC-CKR-3; C-C CKR-3
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| Target Type | Discontinued Target | ||||
| Gene Name | CCR3 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-(1,2-Diphenyl-ethyl)-3-(3-hydroxy-propyl)-urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL126106; BDBM50117453
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
11-Butyl-3-[1-(4,6-dimethylpyrimidine-5-carbonyl)-4-methyl-4-piperidyl]-9-[(4-ethoxycyclohexyl)methyl]-3,9-diazaspiro[5.5]undecan-10-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL449621; SCHEMBL3963928; BDBM50254750
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
PharmaGSID_48521
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078231; DSSTox_CID_28495; DSSTox_RID_82770; DSSTox_GSID_48521; DTXSID8048521; SCHEMBL18841093; Tox21_303454; BDBM50310739; NCGC00257432-01
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Ethyl (2R)-2-benzamido-3-(4-hydroxyphenyl)propanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL33658; SCHEMBL1796825; n-benzoyl-d-tyrosine ethyl ester; ZINC2036673; BDBM50100035; AKOS015908297; (R)-2-Benzoylamino-3-(4-hydroxy-phenyl)-propionic acid ethyl ester
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-[2-(4-Cyclohexyl-piperazin-1-yl)-2-phenyl-ethyl]-2-(3,5-dichloro-phenyl)-acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL192384; SCHEMBL18840874; BDBM50162406
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| Activity |
Ki = 62500 nM
|
[5] | |||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-[1-(1-Benzyl-piperidin-4-ylmethyl)-2-methyl-propyl]-4-methyl-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL121743; BDBM50133797
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| Activity |
IC50 > 200000 nM
|
[6] | |||
| Compound Name |
N-{1-[4-(3,4-Dichloro-benzyl)-cyclohexylmethyl]-2-methyl-propyl}-4-methyl-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL121588; BDBM50133794
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| Activity |
IC50 > 200000 nM
|
[6] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists. J Med Chem. 2002 Aug 15;45(17):3794-804. | ||||
| REF 2 | Discovery of a potent, selective and orally bioavailable 3,9-diazaspiro[5.5]undeca-2-one CCR5 antagonist. Bioorg Med Chem Lett. 2009 Jan 1;19(1):209-13. | ||||
| REF 3 | Spiropiperidine CCR5 antagonists. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5401-6. | ||||
| REF 4 | Discovery of potent and selective phenylalanine derived CCR3 antagonists. Part 1. Bioorg Med Chem Lett. 2001 Jun 4;11(11):1441-4. | ||||
| REF 5 | Novel ligands for the chemokine receptor-3 (CCR3): a receptor-modeling study based on 5D-QSAR. J Med Chem. 2005 Mar 10;48(5):1515-27. | ||||
| REF 6 | Design and synthesis of novel CCR3 antagonists. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3597-600. | ||||
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