Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T03755 | Target Info | |||
| Target Name | Apoptosis regulator Bcl-W (BCL-W) | ||||
| Synonyms |
KIAA0271; Bcl2-L-2; Bcl-2-like protein 2; BCLW
Click to Show/Hide
|
||||
| Target Type | Clinical trial Target | ||||
| Gene Name | BCL2L2 | ||||
| Biochemical Class | B-cell lymphoma Bcl-2 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 15 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2S)-2-[(5Z)-5-[(4-Bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-(1H-indol-3-yl)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL242969; BDBM50202269; 2-[5-(4-bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl]-3-(3-indolyl)-propanoic acid
Click to Show/Hide
|
||||
| Activity |
Ki = 54200 nM
|
[1] | |||
| Compound Name |
2-Propenyl 2-[5-(4-bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl]-3-phenylpropanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL243411; BDBM50202270
Click to Show/Hide
|
||||
| Activity |
Ki = 56800 nM
|
[1] | |||
| Compound Name |
2-[5-(1-Phenylethylidene)-4-oxo-2-thioxothiazolidin-3-yl]-4-methylpentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL242339; BDBM50202282
Click to Show/Hide
|
||||
| Activity |
Ki = 58300 nM
|
[1] | |||
| Compound Name |
4-[8-Ethylsulfanyl-3-(4-hydroxyphenyl)-3-methyloctan-4-yl]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2374449; BDBM50024671
Click to Show/Hide
|
||||
| Activity |
Ki = 59320 nM
|
[2] | |||
| Compound Name |
2-[5-(Diphenylmethylidene)-4-oxo-2-thioxothiazolidin-3-yl]-4-methylpentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL439400; BDBM50202274
Click to Show/Hide
|
||||
| Activity |
Ki = 61900 nM
|
[1] | |||
| Compound Name |
2-[5-(4-Bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl]-4-methylthiobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL241897; BDBM50202278
Click to Show/Hide
|
||||
| Activity |
Ki = 88000 nM
|
[1] | |||
| Compound Name |
2-[2-[2-[(2S)-2-[(5Z)-5-[(4-Bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoyl]oxyethoxy]ethoxy]ethyl (2S)-2-[(5Z)-5-[(4-bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL256858; BDBM50372174
Click to Show/Hide
|
||||
| Activity |
Ki = 88300 nM
|
[3] | |||
| Compound Name |
2-[2-[(2S)-2-[(5Z)-5-[(4-Bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoyl]oxyethoxy]ethyl (2S)-2-[(5Z)-5-[(4-bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL402066; BDBM50372179
Click to Show/Hide
|
||||
| Activity |
Ki = 99000 nM
|
[3] | |||
| Compound Name |
2-[(2S)-2-[(5Z)-5-[(4-Bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoyl]oxyethyl (2S)-2-[(5Z)-5-[(4-bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL272110; BDBM50372175
Click to Show/Hide
|
||||
| Activity |
Ki = 101000 nM
|
[3] | |||
| Compound Name |
Chelerythrine chloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Chelerythrinechloride; Chelerythrine hydrochloride; UNII-7IC98TZ0PZ; Chelerythrine (chloride); 7IC98TZ0PZ; CHEMBL258893; 1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridiniumchloride; MFCD00060717; 1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;chloride; 1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride; 3895-92-9 (chloride); 34316-15-9 (cation).; C21H18ClNO4; 1,2-Dimethoxy-12-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride; Chelerythrine HCl; NSC646662; 1,2-Dimethoxy-N-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride; Chelerythrine, chloride; EINECS 223-444-9; NSC 36405; SR-01000075750; Chelerythrine cloride; Chelerythrine, hydrochloride; SCHEMBL195109; KS-00001CVS; DTXSID70893481; BCPP000287; HMS3229C07; HMS3260B04; HMS3672K05; NSC36405; Tox21_500241; NSC-36405; AKOS016010038; BCP9000516; CCG-206741; CS-0205; LP00241; NSC-646662; NCGC00093703-01; NCGC00260926-01; AK115162; AS-17480; HY-12048; SC-76777; BCP0726000282; DB-049354; Chelerythrine Chloride - CAS 3895-92-9; EU-0100241; FT-0602998; V0358; Chelerythrine, hydroxide, hydrochloride (8CI); A10196; C 2932; W-5057; Q-100414; Q-200824; Q-200825; SR-01000075750-1; Q27268347; [1,6-c]phenanthridinium, 1,2-dimethoxy-12-methyl-, chloride; 1,2-DIMETHOXY-N-METHYL-[1,3]BENZODIOXOLO[5,6-C]PHE; 1,2-dimethoxy-n-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride
Click to Show/Hide
|
||||
| Activity |
Ki = 106000 nM
|
[1] | |||
| Compound Name |
Ethyl (2S)-2-[(5Z)-5-[(4-bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL257687; BDBM50372172
Click to Show/Hide
|
||||
| Activity |
Ki = 116000 nM
|
[3] | |||
| Compound Name |
Prop-2-enyl (2S)-2-(5-benzhydrylidene-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)-3-phenylpropanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL396500; BDBM50202276; 2-propenyl 2-[5-biphenylmethylidene-4-oxo-2-thioxothiazolidin-3-yl]-3-phenylpropanoate
Click to Show/Hide
|
||||
| Activity |
Ki = 116000 nM
|
[1] | |||
| Compound Name |
5-[(4-Bromophenyl)methylene]-a-(1-methylethyl)-4-oxo-2-thioxo-3-thiazolidineacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BH3I-1; CHEMBL241895; Probes1_000048; Probes1_000085; Probes2_000066; Probes2_000362; 2-[5-(4-bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl]-3-methylbutanoic acid; BDBM50202280; MFCD03453544; AKOS025295084; CS-5730; AS-55873; HY-100383; BH3I-1, >=97% (HPLC), powder, yellow; J-017769
Click to Show/Hide
|
||||
| Activity |
Ki = 124000 nM
|
[1] | |||
| Compound Name |
Antimycin A3
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Blastomycin; Antimycin A3b; Blastmycin; Purothionin AII; UNII-97YBD5W80B; NSC58239; 97YBD5W80B; CHEMBL436605; A 80021F34; A1-Purothionin; SCHEMBL158729; DTXSID7037189; ZINC4212164; BDBM50107132; NSC-58239; NCI60_004417; Q27272047; UNII-7JMI3P2Y5R component PVEVXUMVNWSNIG-PDPGNHKXSA-N; UNII-8S75R39Y6J component PVEVXUMVNWSNIG-PDPGNHKXSA-N; WLN: T9OV EOVTJ CMVR CQ DMVH& D1 G4 HOVX1&1&1 I1; Threonine, 2-(1,2-dihydroxypropyl)hexanoate, 7-lactone, isovalerate
Click to Show/Hide
|
||||
| Activity |
Ki = 127000 nM
|
[1] | |||
| Compound Name |
5-(4-Bromobenzylidene)-3-(1-morpholino-1-oxo-3-phenylpropan-2-yl)-4-oxo-2-thioxothiazolidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL243203; BDBM50202285
Click to Show/Hide
|
||||
| Activity |
Ki = 146000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 3 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-[5-(4-Bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL394857; ZINC1748030; BDBM50202284
Click to Show/Hide
|
||||
| Activity |
Ki = 243000 nM
|
[1] | |||
| Compound Name |
2-[5-(4-Bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl]-glutaric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390913; BDBM50202273
Click to Show/Hide
|
||||
| Activity |
Ki = 610000 nM
|
[1] | |||
| Compound Name |
2-Propenyl 2-[5-(4-bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl]-3-propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL396499; BDBM50202281
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Development of selective inhibitors for anti-apoptotic Bcl-2 proteins from BHI-1. Bioorg Med Chem. 2007 Mar 1;15(5):2167-76. | ||||
| REF 2 | Structure-activity relationship studies of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an antagonist for antiapoptotic Bcl-2 proteins to overcome drug resistance in cancer. J Med Chem. 2006 Dec 28;49(26):7731-9. | ||||
| REF 3 | Development of dimeric modulators for anti-apoptotic Bcl-2 proteins. Bioorg Med Chem Lett. 2008 Jan 1;18(1):236-40. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.