Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T04696 | Target Info | |||
| Target Name | Tyrosyl-DNA phosphodiesterase 2 (TDP2) | ||||
| Synonyms |
hTDP2; VPg unlinkase; Tyrosyl-RNA phosphodiesterase; Tyr-DNA phosphodiesterase 2; TRAF and TNF receptor-associated protein; TDP2; ETS1-associated protein II; ETS1-associated protein 2; EAPII; 5'-tyrosyl-DNA phosphodiesterase; 5'-Tyr-DNA phosphodiesterase
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|
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| Target Type | Literature-reported Target | ||||
| Gene Name | TDP2 | ||||
| Biochemical Class | Phosphoric diester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 94 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Camptothecin
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|
Phase 3 | Compound Info | ||
| Synonyms |
camptothecin; Camptothecine; 7689-03-4; (S)-(+)-Camptothecin; Campathecin; d-Camptothecin; (+)-Camptothecine; (+)-Camptothecin; 20(S)-Camptothecine; 21,22-Secocamptothecin-21-oic acid lactone; NSC94600; (S)-Camptothecin; Camptothecine (8CI); 20(S)-Camptothecin; Camptothecine (S,+); CHEMBL65; UNII-XT3Z54Z28A; MLS000766223; (4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; XT3Z54Z28A; CHEBI:27656; VSJKWCGYPAHWDS-FQEVSTJZSA-N; Camptothecin, Camptotheca acuminata; NSC-94600; Camptothecin derivat
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|
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| Activity |
IC50 ~ 111000 nM
|
[1] | |||
| Compound Name |
NSC-95397
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Investigative | Compound Info | ||
| Synonyms |
NSC 95397; 93718-83-3; 2,3-Bis(2-hydroxyethylthio)-1,4-naphthalenedione; NSC95397; NSC-95397; 2,3-bis(2-hydroxyethylsulfanyl)naphthalene-1,4-dione; MLS002153403; CHEMBL429095; SMR001230781; SR-01000075930; 1,4-Naphthalenedione, 2,3-bis[(2-hydroxyethyl)thio]-; Tocris-1547; AC1Q6JAF; Lopac-N-1786; Lopac0_000629; KBioGR_000495; BSPBio_001155; KBioSS_000495; SCHEMBL2530685; AC1L66Q4; cid_262093; KBio3_000910; KBio2_005631; KBio2_003063; CHEBI:93193; KBio3_000909; KBio2_000495; CTK3I8111; DTXSID10294236; MolPort-003-958-936; HMS3268C19
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|
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| Activity |
IC50 = 71000 nM
|
[2] | |||
| Compound Name |
Chembl4163458
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17918890; BDBM50373920
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|
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
Chembl4160844
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50378169
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|
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
O1C(=CC=C1)C1=CC=C2CC(NC(C2=C1)=O)=O
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3794329; SCHEMBL18010843; BDBM50161992
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|
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| Activity |
IC50 = 50000 nM
|
[4] | |||
| Compound Name |
Chembl4169561
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50378148
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|
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| Activity |
IC50 = 51000 nM
|
[3] | |||
| Compound Name |
Chembl4175665
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17918866; BDBM50374214
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|
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| Activity |
IC50 = 51000 nM
|
[3] | |||
| Compound Name |
Chembl4161031
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17918982; BDBM50374215
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|
||||
| Activity |
IC50 = 53000 nM
|
[3] | |||
| Compound Name |
Chembl4167718
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17912288; BDBM50376465
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|
||||
| Activity |
IC50 = 54000 nM
|
[3] | |||
| Compound Name |
6-(3-Aminophenyl)-4H-isoquinoline-1,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3792554; SCHEMBL18010827; BDBM50162069
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|
||||
| Activity |
IC50 = 55000 nM
|
[4] | |||
| Compound Name |
Schembl21803677
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4063586; BDBM50257101
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|
||||
| Activity |
IC50 = 61600 nM
|
[5] | |||
| Compound Name |
Chembl4167695
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17918869; BDBM50375550
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|
||||
| Activity |
IC50 = 66000 nM
|
[3] | |||
| Compound Name |
Chembl4161640
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17918942; BDBM50378147
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|
||||
| Activity |
IC50 = 68000 nM
|
[3] | |||
| Compound Name |
Chembl4166134
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17918937; BDBM50378175
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|
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| Activity |
IC50 = 71000 nM
|
[3] | |||
| Compound Name |
2-[3-(Dimethylamino)propyl]-3,4-(1,2-phenylenecarbonyl)-1,2-dihydro-2,7-naphthyridine-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3581877; SCHEMBL19372728; BDBM50090918; J3.605.557J
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|
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| Activity |
IC50 = 80000 nM
|
[6] | |||
| Compound Name |
Chembl4169093
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50378177
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|
||||
| Activity |
IC50 = 88000 nM
|
[3] | |||
| Compound Name |
Chembl4171508
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50376554
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|
||||
| Activity |
IC50 = 99000 nM
|
[3] | |||
| Compound Name |
Schembl21803664
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4076362; BDBM50257119
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|
||||
| Activity |
IC50 = 104000 nM
|
[5] | |||
| Compound Name |
Schembl21803651
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4063011; BDBM50257104
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|
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| Activity |
IC50 = 107000 nM
|
[5] | |||
| Compound Name |
Schembl21803652
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4070873; BDBM50257124
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|
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| Activity |
IC50 = 108000 nM
|
[5] | |||
| Compound Name |
6-[(2S)-2,3-Dihydroxypropyl]indeno[1,2-c][2,7]naphthyridine-5,11-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809548; SCHEMBL19372559; BDBM50172713
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|
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| Activity |
IC50 = 111000 nM
|
[6] | |||
| Compound Name |
6-[3-(Dimethylamino)propyl]indeno[2,1-f][1,7]naphthyridine-5,11-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809424; SCHEMBL19372718; BDBM50172705
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|
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| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
O=C1NC(CC2=CC(=CC=C12)C1=C(C(=O)O)C=CC=C1)=O
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793508; SCHEMBL18010823; BDBM50162071
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|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
6-[(2S)-2,3-Dihydroxypropyl]indeno[1,2-h][1,6]naphthyridine-5,11-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809688; SCHEMBL19372556; BDBM50172692
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|
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| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
3-Amino-2-phenyl-2H-pyrazolo[4,3-c]pyridine-4,6(5H,7H)-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3794195; ChemDiv2_002433; Oprea1_048100; SCHEMBL12783061; CTK7H5611; ZINC64044; 3-amino-2-phenyl-7H-pyrazolo[4,3-c]pyridine-4,6-dione; HMS1375O13; BDBM50161960; AKOS024283093; MCULE-9440571916; ST060263; EU-0051578; SR-01000516980; SR-01000516980-1; 3-Amino-2-phenyl-2H-pyrazolo[4,3-c]pyridine-4,6(5H,7H)-dione #; 3-amino-2-phenyl-5,7-dihydropyrazolo[4,3-c]pyridine-4,6-dione; Pyrazolo[4,3-c]pyridine-4,6(5H,7H)-dione, 3-amino-2-phenyl-; 2-Phenyl-3-amino-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-4,6-dione
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|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
7-Phenyl-1H-quinazoline-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793103; SCHEMBL17412363; BDBM50161965
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|
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| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
Chembl4176371
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17918983; BDBM50378159
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|
||||
| Activity |
IC50 ~ 111000 nM
|
[3] | |||
| Compound Name |
6-[(2S)-2,3-Dihydroxypropyl]indeno[2,1-f][1,7]naphthyridine-5,11-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809626; SCHEMBL19372722; BDBM50172694
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|
||||
| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
Schembl21803658
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090922; BDBM50257102
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|
||||
| Activity |
IC50 ~ 111000 nM
|
[5] | |||
| Compound Name |
6-(3-Morpholin-4-ylpropyl)indeno[2,1-f][1,7]naphthyridine-5,11-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3808575; SCHEMBL19372717; BDBM50172711
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|
||||
| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
Chembl4169637
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17912291; BDBM50376553
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|
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| Activity |
IC50 ~ 111000 nM
|
[3] | |||
| Compound Name |
Chembl4165069
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17918877; BDBM50373356
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|
||||
| Activity |
IC50 ~ 111000 nM
|
[3] | |||
| Compound Name |
Schembl22364354
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809706; BDBM50172725
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|
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| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
Schembl21803673
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4064072; BDBM50257105
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|
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| Activity |
IC50 ~ 111000 nM
|
[5] | |||
| Compound Name |
Schembl21803674
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4083140; BDBM50257089
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|
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| Activity |
IC50 ~ 111000 nM
|
[5] | |||
| Compound Name |
1,3-Dioxo-1,2,3,4-tetrahydro-isoquinoline-6-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3792469; SCHEMBL3576380; BDBM50161996; 1,3-dioxo-4H-isoquinoline-6-carboxylic acid
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| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
Schembl21803662
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4099136; BDBM50257122
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|
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| Activity |
IC50 ~ 111000 nM
|
[5] | |||
| Compound Name |
Schembl21803683
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4085641; BDBM50257127
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|
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| Activity |
IC50 ~ 111000 nM
|
[5] | |||
| Compound Name |
Chembl4169597
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50378161
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|
||||
| Activity |
IC50 ~ 111000 nM
|
[3] | |||
| Compound Name |
Chembl4161672
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17918923; BDBM50374213
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|
||||
| Activity |
IC50 ~ 111000 nM
|
[3] | |||
| Compound Name |
6-(3-Phenylphenyl)-4H-isoquinoline-1,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793886; SCHEMBL18010829; BDBM50161972
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|
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| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
7-(2-Furyl)-2-hydroxy-4H-isoquinoline-1,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1928097; 7-(Furan-2-Yl)-2-Hydroxyisoquinoline-1,3(2h,4h)-Dione; SCHEMBL18010846; BDBM50162042; 7-(furan-2-yl)-2-hydroxy-4H-isoquinoline-1,3-dione
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|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
6-(3-Morpholin-4-ylpropyl)indeno[1,2-h][1,6]naphthyridine-5,11-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3810067; SCHEMBL19372716; BDBM50172498
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|
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| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
6-[(2S)-2,3-Dihydroxypropyl]-3-iodoindeno[1,2-c]isoquinoline-5,11-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3581863; BDBM50090917
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|
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| Activity |
IC50 ~ 111000 nM
|
[7] | |||
| Compound Name |
6-(3-Imidazol-1-ylpropyl)indeno[1,2-c][2,7]naphthyridine-5,11-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3581878; SCHEMBL19372724; BDBM50172722
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|
||||
| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
6-[3-(Dimethylamino)propyl]indeno[1,2-h][1,6]naphthyridine-5,11-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809255; SCHEMBL19372726; BDBM50172685
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|
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| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
6-(Furan-2-yl)benzo[de]isoquinoline-1,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3794399; BDBM50161963
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| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
6-(3-Imidazol-1-ylpropyl)indeno[1,2-c][2,6]naphthyridine-5,11-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3808668; SCHEMBL19372725; BDBM50172718
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|
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| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
3-Amino-2-(4-fluorophenyl)-7H-pyrazolo[4,3-c]pyridine-4,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793241; SCHEMBL12783648; BDBM50161962
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|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
Schembl21803696
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4079995; BDBM50257100
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[5] | |||
| Compound Name |
6-(3-Morpholin-4-ylpropyl)indeno[1,2-c][2,6]naphthyridine-5,11-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3810072; SCHEMBL19372723; BDBM50172719
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
C(C1=CC=CC=C1)C=1C=C2CC(NC(C2=CC=1)=O)=O
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3792579; SCHEMBL18010818; BDBM50161969
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
Schembl21803682
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087581; BDBM50237808
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[1] | |||
| Compound Name |
Chembl4159314
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Investigative | Compound Info | ||
| Synonyms |
BDBM50378176
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|
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| Activity |
IC50 ~ 111000 nM
|
[3] | |||
| Compound Name |
Schembl21803653
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4079315; BDBM50257107
Click to Show/Hide
|
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| Activity |
IC50 ~ 111000 nM
|
[5] | |||
| Compound Name |
Schembl21803687
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094373; BDBM50257125
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[5] | |||
| Compound Name |
NC=1C=C(C=CC=1)C1=CC=C2CC(NC(C2=C1)=O)=O
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793891; SCHEMBL18010816; BDBM50162068
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
Chembl4172896
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Investigative | Compound Info | ||
| Synonyms |
BDBM50374212
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|
||||
| Activity |
IC50 ~ 111000 nM
|
[3] | |||
| Compound Name |
5-Fluoro-14-methoxy-9-(3-morpholin-4-ylpropyl)-9,12-diazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2(7),3,5,11(16),12,14-heptaene-8,17-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4072994; BDBM50257090
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[5] | |||
| Compound Name |
6-(Furan-2-yl)-2-hydroxy-4H-isoquinoline-1,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1928103; SCHEMBL18010798; BDBM50161990
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
Chembl4163092
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17919021; BDBM50378149
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[3] | |||
| Compound Name |
3-Amino-2-pyridin-3-yl-7H-pyrazolo[4,3-c]pyridine-4,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793579; BDBM50161961
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
Schembl21803655
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4103520; BDBM50257099
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[5] | |||
| Compound Name |
Chembl4175970
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Investigative | Compound Info | ||
| Synonyms |
BDBM50376551
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|
||||
| Activity |
IC50 ~ 111000 nM
|
[3] | |||
| Compound Name |
Chembl4166710
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17918980; BDBM50377010
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[3] | |||
| Compound Name |
Chembl4176758
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17918865; BDBM50374219
Click to Show/Hide
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||||
| Activity |
IC50 ~ 111000 nM
|
[3] | |||
| Compound Name |
Chembl4166527
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17918905; BDBM50378172
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[3] | |||
| Compound Name |
Schembl22364356
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3810182; BDBM50172712
Click to Show/Hide
|
||||
| Activity |
IC50 = 111000 nM
|
[6] | |||
| Compound Name |
Chembl4161227
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50378174
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[3] | |||
| Compound Name |
6-Bromobenzo[de]isoquinoline-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1H-Benz[de]isoquinoline-1,3(2H)-dione, 6-bromo-; 6-Bromo-1H-benzo[de]isoquinoline-1,3(2H)-dione; CHEMBL3793391; NSC201727; 4-bromo-1,8-naphthalimide; SCHEMBL1888975; DTXSID00308053; 4-Bromonaphthalene-1,8-dicarbimide; ZINC1735574; BDBM50161964; 4-bromonaphthalene-1,8-dicarboximide; AKOS000297459; NSC-201727; AS-67612; CS-0060745; 10-bromo-3-azatricyclo[7.3.1.0?,??]trideca-1(13),5,7,9,11-pentaene-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
6-Quinolin-3-yl-4H-isoquinoline-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793669; SCHEMBL18010813; BDBM50161970
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
6-(3-Imidazol-1-ylpropyl)indeno[2,1-f][1,7]naphthyridine-5,11-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809703; SCHEMBL19372727; BDBM50172710
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
Chembl4174619
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17918879; BDBM50378170
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[3] | |||
| Compound Name |
Chembl4165352
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50378173
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[3] | |||
| Compound Name |
N-(4,6-Dioxo-2-phenyl-7H-pyrazolo[4,3-c]pyridin-3-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793472; SCHEMBL12783742; BDBM50161959
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
5-Fluoro-14-methoxy-9-[3-(4-methylpiperazin-1-yl)propyl]-9,12-diazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2(7),3,5,11(16),12,14-heptaene-8,17-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4068761; BDBM50257121
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[5] | |||
| Compound Name |
Schembl22364348
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809831; BDBM50172724
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
Schembl21803678
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4072940; BDBM50257120
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[5] | |||
| Compound Name |
Chembl4171800
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17918871; BDBM50377906
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[3] | |||
| Compound Name |
Chembl4173499
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17918872; BDBM50378178
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[3] | |||
| Compound Name |
O1C(=CC=C1)C1=C2CC(NC(C2=CC=C1)=O)=O
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793523; SCHEMBL18010804; BDBM50162041
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
Schembl21803665
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4101133; BDBM50257126
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[5] | |||
| Compound Name |
Chembl4170681
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50378158
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[3] | |||
| Compound Name |
Schembl21803669
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4077196; BDBM50257106
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[5] | |||
| Compound Name |
6-[(2S)-2,3-Dihydroxypropyl]indeno[1,2-c][2,6]naphthyridine-5,11-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3808629; SCHEMBL19372555; BDBM50172716
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
6-(3-Morpholin-4-ylpropyl)indeno[1,2-c][2,7]naphthyridine-5,11-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3581876; SCHEMBL19372720; BDBM50172723
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
6-(3-Imidazol-1-ylpropyl)indeno[1,2-h][1,6]naphthyridine-5,11-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809052; SCHEMBL19372721; BDBM50172654
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[6] | |||
| Compound Name |
C1(=CC=CC=C1)C=1C=C2CC(NC(C2=CC=1)=O)=O
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793861; SCHEMBL18010841; BDBM50162043
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[4] | |||
| Compound Name |
Chembl4165089
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50378179
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 111000 nM
|
[3] | |||
| Compound Name |
Schembl22364355
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3808646; BDBM50172715
Click to Show/Hide
|
||||
| Activity |
IC50 = 111000 nM
|
[6] | |||
| Compound Name |
3-[4-(3,4-Dimethoxyphenyl)thiophen-2-yl]-N-methylsulfonylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2420490; BDBM50438885
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 150000 nM
|
[2] | |||
| Compound Name |
N-[4-(3,4-Dimethoxyphenyl)thiophen-2-yl]-1-methyl-6-oxo-5-phenylmethoxypyrimidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2420488; BDBM50438887
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 150000 nM
|
[2] | |||
| Compound Name |
[1-[4-(3,4-Dimethoxyphenyl)thiophene-2-carbonyl]piperidin-3-yl]-dimethoxyphosphorylmethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2420489; BDBM50438886
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 150000 nM
|
[2] | |||
| Compound Name |
4-[4-(3,4-Dimethoxyphenyl)thiophen-2-yl]-N-methylsulfonylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2420491; BDBM50438884
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 150000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and Biological Evaluation of the First Triple Inhibitors of Human Topoisomerase 1, Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), and Tyrosyl-DNA Phosphodiesterase 2 (Tdp2). J Med Chem. 2017 Apr 27;60(8):3275-3288. | ||||
| REF 2 | Toxoflavins and deazaflavins as the first reported selective small molecule inhibitors of tyrosyl-DNA phosphodiesterase II. J Med Chem. 2013 Aug 22;56(16):6352-70. | ||||
| REF 3 | Synthesis and structure-activity relationship of furoquinolinediones as inhibitors of Tyrosyl-DNA phosphodiesterase 2 (TDP2). Eur J Med Chem. 2018 May 10;151:777-796. | ||||
| REF 4 | Isoquinoline-1,3-diones as Selective Inhibitors of Tyrosyl DNA Phosphodiesterase II (TDP2). J Med Chem. 2016 Mar 24;59(6):2734-46. | ||||
| REF 5 | Design and Synthesis of Chlorinated and Fluorinated 7-Azaindenoisoquinolines as Potent Cytotoxic Anticancer Agents That Inhibit Topoisomerase I. J Med Chem. 2017 Jul 13;60(13):5364-5376. | ||||
| REF 6 | Investigation of the Structure-Activity Relationships of Aza-A-Ring Indenoisoquinoline Topoisomerase I Poisons. J Med Chem. 2016 Apr 28;59(8):3840-53. | ||||
| REF 7 | Discovery of potent indenoisoquinoline topoisomerase I poisons lacking the 3-nitro toxicophore. J Med Chem. 2015 May 14;58(9):3997-4015. | ||||
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