Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T06773 | Target Info | |||
| Target Name | Hypoxia-inducible factor 1 (HIF-1) | ||||
| Synonyms |
HIF-1
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| Target Type | Patented-recorded Target | ||||
| Gene Name | NO-GeName | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 16 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Ethyl 5-[(4-chlorophenyl)sulfonylamino]-3-methyl-1-benzofuran-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805275; BDBM50230135
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| Activity | Hypoxia-inducible factor 1 alpha |
IC50 = 50000 nM
|
[1] | ||
| Compound Name |
Moracin M
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Investigative | Compound Info | ||
| Synonyms |
Veraphenol; 5-(6-hydroxy-1-benzofuran-2-yl)benzene-1,3-diol; 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol; UNII-L9FI83128D; 5-(6-Hydroxy-benzofuran-2-yl)-benzene-1,3-diol; 6,3',5'-Trihydroxy-2-phenylbenzofuran; CHEMBL512578; L9FI83128D; 1,3-benzenediol, 5-(6-hydroxy-2-benzofuranyl)-; MLS000697562; SCHEMBL1740981; CTK1H1147; DTXSID20204861; HMS2269O04; ZINC6092566; BDBM50250915; AKOS022661579; MCULE-9347056916; 3',5',6-trihydroxy-2-phenylbenzofuran; NCGC00247527-01; SMR000470919; HY-122942; CS-0090595; 5-(6-Hydroxy-2-benzofuranyl)-1,3-Benzenediol; 5-(6-hydroxy-1-benzofuran-2-yl)-1,3-benzenediol; 5-(6-Hydroxy-2-benzofuranyl)-1,3-benzenediol, 9CI; Q15634179
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| Activity | Hypoxia-inducible factor 1 alpha |
IC50 ~ 50000 nM
|
[2] | ||
| Compound Name |
2-{[4-(3-Phenylureido)phenylamino]methyl}-benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1783628; BDBM50345988
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| Activity | Hypoxia-inducible factor 1 alpha |
IC50 = 51700 nM
|
[3] | ||
| Compound Name |
1-[4-(3-Methoxy-benzylamino)phenyl]-3-phenylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1783626; BDBM50345986
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| Activity | Hypoxia-inducible factor 1 alpha |
IC50 = 52100 nM
|
[3] | ||
| Compound Name |
3-[[4-(3-Phenylureido)phenyl]aminomethyl]phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1783623; BDBM50345983; 1-[4-(3-Hydroxy-benzylamino)phenyl]-3-phenylurea
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| Activity | Hypoxia-inducible factor 1 alpha |
IC50 = 69900 nM
|
[3] | ||
| Compound Name |
2-(4-Cyclohexylphenoxy)-N-(2-hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL602668; BDBM50306567
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| Activity | Hypoxia-inducible factor 1 alpha |
IC50 = 70400 nM
|
[4] | ||
| Compound Name |
3-(2-(4-Cyclohexylphenoxy)acetamido)-4-hydroxyphenylboronic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL601646; BDBM50306572
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| Activity | Hypoxia-inducible factor 1 alpha |
IC50 = 84800 nM
|
[4] | ||
| Compound Name |
N-(2-Hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-2-(p-tolyloxy)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL603103; BDBM50306564
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| Activity | Hypoxia-inducible factor 1 alpha |
IC50 = 90600 nM
|
[4] | ||
| Compound Name |
2-(4-Ethylphenoxy)-N-(2-hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL603712; BDBM50306565
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| Activity | Hypoxia-inducible factor 1 alpha |
IC50 = 91800 nM
|
[4] | ||
| Compound Name |
3-(2-(4-Ethylphenoxy)acetamido)-4-hydroxyphenylboronic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602062; BDBM50306570
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| Activity | Hypoxia-inducible factor 1 alpha |
IC50 ~ 100000 nM
|
[4] | ||
| Compound Name |
3-(2-(Biphenyl-4-yloxy)acetamido)-4-hydroxyphenylboronic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL601645; BDBM50306571
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| Activity | Hypoxia-inducible factor 1 alpha |
IC50 ~ 100000 nM
|
[4] | ||
| Compound Name |
2-(Biphenyl-4-yloxy)-N-(2-hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602667; BDBM50306566
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| Activity | Hypoxia-inducible factor 1 alpha |
IC50 ~ 100000 nM
|
[4] | ||
| Compound Name |
4-{[4-(3-Phenylureido)phenylamino]methyl}-benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1783630; BDBM50345990
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| Activity | Hypoxia-inducible factor 1 alpha |
IC50 ~ 100000 nM
|
[3] | ||
| Compound Name |
4-Hydroxy-3-(2-(p-tolyloxy)acetamido)phenylboronic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL601703; BDBM50306569
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| Activity | Hypoxia-inducible factor 1 alpha |
IC50 ~ 100000 nM
|
[4] | ||
| Compound Name |
(3S)-2'-Bromo-5'-[[(3S)-4'-bromo-8-hydroxy-3'-oxospiro[6,10,15-triazatetracyclo[7.6.1.02,7.012,16]hexadeca-1(15),2(7),8,10,12(16)-pentaene-3,6'-cyclohexa-1,4-diene]-1'-yl]disulfanyl]-8-hydroxyspiro[6,10,15-triazatetracyclo[7.6.1.02,7.012,16]hexadeca-1(15),2(7),8,10,12(16)-pentaene-3,4'-cyclohexa-2,5-diene]-1'-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3938903; BDBM50190658
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| Activity | Hypoxia-inducible factor 1 alpha |
IC50 ~ 100000 nM
|
[5] | ||
| Compound Name |
1-[4-[4-(Methoxycarbonyl)benzylamino]phenyl]-3-phenylurea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1783632; BDBM50345993; 4-{[4-(3-Phenylureido)phenylamino]methyl}-benzoic acid methyl ester
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| Activity | Hypoxia-inducible factor 1 alpha |
IC50 ~ 100000 nM
|
[3] | ||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and evaluation of N-(benzofuran-5-yl)aromaticsulfonamide derivatives as novel HIF-1 inhibitors that possess anti-angiogenic potential. Bioorg Med Chem. 2017 Mar 15;25(6):1737-1746. | ||||
| REF 2 | Hypoxia-inducible factor-1 inhibitory benzofurans and chalcone-derived diels-alder adducts from Morus species. J Nat Prod. 2009 Jan;72(1):39-43. | ||||
| REF 3 | 1-[4-(N-Benzylamino)phenyl]-3-phenylurea derivatives as a new class of hypoxia-inducible factor-1alpha inhibitors. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3166-9. | ||||
| REF 4 | Boron-containing phenoxyacetanilide derivatives as hypoxia-inducible factor (HIF)-1alpha inhibitors. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1453-6. | ||||
| REF 5 | Screening and Biological Effects of Marine Pyrroloiminoquinone Alkaloids: Potential Inhibitors of the HIF-1alpha/p300 Interaction. J Nat Prod. 2016 May 27;79(5):1267-75. | ||||
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