Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T06792 | Target Info | |||
| Target Name | Proteasome beta-9 (PS beta-9) | ||||
| Synonyms |
Really interesting new gene 12 protein; RING12; Proteasome subunit beta-1i; Proteasome subunit beta type-9; Proteasome chain 7; PSMB6i; Multicatalytic endopeptidase complex chain 7; Macropain chain 7; Low molecular mass protein 2; LMP2
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| Target Type | Patented-recorded Target | ||||
| Gene Name | PSMB9 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4290977
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Investigative | Compound Info | ||
| Synonyms |
BDBM50464968
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| Activity |
IC50 = 52000 nM
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[1] | |||
| Compound Name |
Chembl4283534
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Investigative | Compound Info | ||
| Synonyms |
BDBM50464975
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| Activity |
IC50 = 59000 nM
|
[1] | |||
| Compound Name |
N-[(2R)-1-[[(2S)-3-(1H-Indol-3-yl)-1-[[(E,2S)-4-methylsulfonyl-1-phenylbut-3-en-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-3-methyl-1H-indene-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3319591; LU-055i; BDBM50099836
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
N-[(2R)-1-[[(2S)-1-[[(2S)-3-Cyclohexyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]amino]-3-(4-methoxyphenyl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-3-methyl-1H-indene-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3319579; LU-035i; BDBM50099686
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| References | Top | ||||
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| REF 1 | Structure-based design of human immuno- and constitutive proteasomes inhibitors. Eur J Med Chem. 2018 Feb 10;145:570-587. | ||||
| REF 2 | Structure-based design of 1i or 5i specific inhibitors of human immunoproteasomes. J Med Chem. 2014 Jul 24;57(14):6197-209. | ||||
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