Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T07217 | Target Info | |||
| Target Name | Fatty acid-binding protein 4 (FABP4) | ||||
| Synonyms |
Fatty acid-binding protein, adipocyte; Adipocyte-type fatty acid-binding protein; Adipocyte lipid-binding protein; Adipocyte fatty-acid-binding protein; Adipocyte fatty binding protein; ALBP; AFABP; A-FABP
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| Target Type | Patented-recorded Target | ||||
| Gene Name | FABP4 | ||||
| Biochemical Class | Fatty acid binding protein | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 25 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-(2-Oxo-2-(2-(piperidin-1-yl)benzylamino)ethylthio)acetic acido
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1085797; BDBM50319699; AKOS027045785
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| Activity |
IC50 = 56300 nM
|
[1] | |||
| Compound Name |
2-(2-(3-Chloro-4-fluorophenylamino)-2-oxoethylthio)acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1086224; Oprea1_399098; SCHEMBL21968900; ZINC100793; BDBM50319698; AKOS008907361; MCULE-1598065533
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| Activity |
IC50 = 59500 nM
|
[1] | |||
| Compound Name |
5-[2-[5-(4-Chlorophenyl)-1-phenylpyrazol-3-yl]phenoxy]pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2334247; BDBM50429949
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| Activity |
IC50 = 74000 nM
|
[2] | |||
| Compound Name |
6-Bromo-2-methyl-1-[2,4,6-tri(propan-2-yl)phenyl]sulfonylbenzimidazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3400889; BDBM50063858
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| Activity |
IC50 = 82800 nM
|
[3] | |||
| Compound Name |
5-[2-[5-(4-Bromophenyl)-1-phenylpyrazol-3-yl]phenoxy]pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2334253; BDBM50429943
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| Activity |
IC50 = 86000 nM
|
[2] | |||
| Compound Name |
2-(4-Methoxy-indole-1-sulfonyl)-benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL185617; BDBM50152855
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| Activity |
IC50 = 89000 nM
|
[4] | |||
| Compound Name |
2-Phenethyl-6-trifluoromethyl-pyrimidin-4-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL184036; BDBM50152894
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
3-[2,4,6-Tri(propan-2-yl)phenyl]sulfonylbenzimidazol-5-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3400903; BDBM50063852
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[(Pyridin-4-ylmethyl)-amino]-6-trifluoromethyl-pyrimidin-4-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL185298; BDBM50152895
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-[(Biphenyl-4-ylmethyl)-amino]-6-trifluoromethyl-pyrimidin-4-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL183180; BDBM50152884
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2,4,6-Triisopropylbenzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
2,4,6-tri(propan-2-yl)benzenesulfonamide; CHEMBL3400904; MFCD00051975; 2,4,6-tris(methylethyl)benzenesulfonamide; CBMicro_034663; ACMC-1BT32; Oprea1_497094; SCHEMBL1069046; CTK4A3926; DTXSID80352973; ZINC156651; 2,4,6-Triisopropylbenzenesulfonamine; BDBM50063853; SBB058036; 2,4,6-Tri-isopropylbenzenesulfonamide; AKOS024318932; MCULE-8611968173; AS-62953; BIM-0034751.P001; DB-040629; FT-0609882; ST50408004; 2,4,6-tris(propan-2-yl)benzene-1-sulfonamide; Benzenesulfonamide,2,4,6-tris(1-methylethyl)-; A801259
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-Methyl-1-[2,4,6-tri(propan-2-yl)phenyl]sulfonylbenzimidazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3400885; Oprea1_670055; Oprea1_730387; BDBM50063857
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-Nitro-5-(phenylsulfonyl)phenyl 3,5-dichlorobenzenesulfonate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1084578; ZINC3118314; BDBM50319704; CCG-233438; MCULE-5252407237
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(2-(4-(4-Methoxyphenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-ylamino)-2-oxoethylthio)acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1084580; MLS000850052; HMS2801H18; ZINC1029137; BDBM50319706; MCULE-4775154635; SMR000456070
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Carbazol-9-yl-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
2-(9h-carbazol-9-yl)acetic acid; 9-Carbazoleacetic acid; 2-carbazol-9-ylacetic acid; 9H-Carbazole-9-acetic acid; 2-(carbazol-9-yl)acetic acid; UNII-547WS9128O; MFCD00439433; (9-Carbazolyl)acetic acid; 9-(Carboxymethyl)carbazole; 9H-Carbazole-9-aceticacid; CHEMBL185432; 547WS9128O; Carbazyl-N-acetic acid; carbazol-9-ylacetic acid; 9-Carbazoleacetic acid [MI]; 9-(Carboxymethyl)-9H-carbazole; 9-carbazolylacetic acid; Carbazol-9-yl-aceticacid; Maybridge3_003096; Oprea1_004081; Oprea1_866351; 2-(9-carbazolyl)acetic acid; 2-carbazol-9-ylethanoic acid; MLS000703586; SCHEMBL150053; CTK1G9116; KS-00000LCQ; DTXSID10384666; HMS1439M16; HMS2660J05; ZINC2565464; 4926AE; BDBM50152869; SBB010077; AKOS000157701; DS-4927; MCULE-7359951977; VZ31544; IDI1_014483; 9-Carbazoleacetic acid, >=99.0% (T); AK110705; SMR000273951; SY101231; DB-023030; FT-0632289; ST50247537; F10041; Z-2066; A829107; SR-01000361269; SR-01000361269-1; Q27261181
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
3-(2-(2,4-Dichlorophenylsulfonyl)ethylthio)-4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1H-1,2,4-triazol-5(4H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1084579; ZINC1030765; BDBM50319705; CCG-240779; MCULE-1835227346
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[(4-Chlorobenzyl)amino]-6-methylpyrimidin-4(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL185478; 2-{[(4-chlorophenyl)methyl]amino}-6-methyl-3,4-dihydropyrimidin-4-one; MLS000974375; HMS2832G10; KS-00003I1V; BDBM50152892; HTS007572; MFCD06002505; ZINC13113929; AKOS002242814; BS-4627; MCULE-9479931672; SMR000498166; ST50205551; SR-01000289410; 2-(4-Chloro-benzylamino)-6-methyl-pyrimidin-4-ol; SR-01000289410-1; 2-[(4-chlorobenzyl)amino]-6-methyl-4(3H)-pyrimidinone; 2-{[(4-chlorophenyl)methyl]amino}-6-methyl-3-hydropyrimidin-4-one
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-(4-Chloro-benzylamino)-6-(2-fluoro-phenyl)-pyrimidin-4-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL185309; BDBM50152882
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-[[6-(1H-Benzimidazol-2-ylsulfanylmethyl)pyridin-2-yl]methylsulfanyl]-1H-benzimidazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1084821; CBMicro_018634; Oprea1_084434; SCHEMBL14304931; C21H17N5S2; ZINC632400; CCG-6902; BDBM50319697; STL356700; AKOS022096004; MCULE-1250130748; BIM-0018800.P001; SR-01000645493-1; 2,6-bis((1H-benzo[d]imidazol-2-ylthio)methyl)pyridine; 2,2'-[2,6-Pyridinediylbis(methylenethio)]bis(1H-benzimidazole); 2,2'-[pyridine-2,6-diylbis(methanediylsulfanediyl)]bis(1H-benzimidazole)
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-(4-Methylphenyl)-2-[(4-methylphenyl)sulfanyl]-4-oxobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
4-(4-METHYLPHENYL)-2-(4-METHYLPHENYLTHIO)-4-OXOBUTANOIC ACID; CHEMBL1085065; 4-oxo-4-p-tolyl-2-(p-tolylthio)butanoic acid; MLS000541067; Maybridge3_005567; Oprea1_432937; CTK6B9399; HMS1446N01; HMS2183D19; KS-000026UD; BDBM50319703; CCG-53523; MFCD00832393; AKOS005105862; JS-0888; MCULE-3197043221; IDI1_016954; SMR000161798; SR-01000642683-1; 4-(4-Methylphenyl)-2-((4-methylphenyl)thio)-4-oxobutanoic acid; Benzenebutanoic acid, 4-methyl-.alpha.-[(4-methylphenyl)thio]-.gamma.-oxo-
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-Phenylamino-6-trifluoromethyl-pyrimidin-4-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185561; SCHEMBL7223028; SCHEMBL13329004; ZINC9264661; BDBM50152896; AKOS003063091; 2-anilino-6-(trifluoromethyl)-1H-pyrimidin-4-one
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-Phenethylamino-6-trifluoromethyl-pyrimidin-4-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL363985; BDBM50152898
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|
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-(3-Carbamoyl-indole-1-sulfonyl)-benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL184911; BDBM50152868
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-(2-(4,5-Dimethoxy-2-(methoxycarbonyl)phenylamino)-2-oxoethylthio)acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1086457; Oprea1_153123; ZINC116355; BDBM50319702; MCULE-1193700592
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(4-Chloro-benzylamino)-6-phenyl-pyrimidin-4-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364177; ZINC7995030; BDBM50152893; AKOS001900053; MCULE-4608082032; 2-((4-chlorobenzyl)amino)-6-phenylpyrimidin-4(3H)-one; F3308-0630
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-[2-[5-(4-Methylphenyl)-1-phenylpyrazol-3-yl]phenoxy]pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2331584; BDBM50429944
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|
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| Activity |
IC50 = 259000 nM
|
[2] | |||
| Compound Name |
2-[2-[5-(4-Chlorophenyl)-1-phenylpyrazol-3-yl]phenoxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2334245; BDBM50429951
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| Activity |
IC50 > 10000000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3675-9. | ||||
| REF 2 | Structure-guided design, synthesis and in vitro evaluation of a series of pyrazole-based fatty acid binding protein (FABP) 3 ligands. Bioorg Med Chem Lett. 2013 Mar 15;23(6):1662-6. | ||||
| REF 3 | Novel fatty acid binding protein 4 (FABP4) inhibitors: virtual screening, synthesis and crystal structure determination. Eur J Med Chem. 2015 Jan 27;90:241-50. | ||||
| REF 4 | Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8. | ||||
| REF 5 | Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4449-52. | ||||
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