Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T07279 | Target Info | |||
| Target Name | Serine/threonine-protein kinase pim-2 (PIM2) | ||||
| Synonyms |
Pim-2h; PIM2
Click to Show/Hide
|
||||
| Target Type | Clinical trial Target | ||||
| Gene Name | PIM2 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 12 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(5Z)-5-[(4-Propan-2-ylphenyl)methylidene]-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
thiazolidine-2,4-dione, 9a; CHEMBL495827; SCHEMBL2543138; SCHEMBL2543142; BDBM26631; ZINC12382914; 5-(4-Isopropylbenzylidene)thiazolidine-2,4-dione; (5Z)-5-{[4-(propan-2-yl)phenyl]methylidene}-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(5E)-1-Benzyl-5-[(4-methoxyphenyl)methylidene]imidazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL498203; BDBM26649; 5-Arylidene-3-benzylhydantoin, 27c-1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(5E)-1-Benzyl-5-[(4-methoxyphenyl)methylidene]imidazolidine-2,4-dione;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL526284
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(5Z)-3-[[4-(Trifluoromethoxy)phenyl]methyl]-5-[[3-(trifluoromethyl)phenyl]methylidene]-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
thiazolidine-2,4-dione, 5a; CHEMBL497606; SCHEMBL2542486; SCHEMBL2542491; BDBM26627
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(5E)-1-Benzyl-5-[(4-chlorophenyl)methylidene]imidazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL496588; SCHEMBL2542527
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(5E)-1-Benzyl-5-[(4-bromophenyl)methylidene]imidazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL522916; BDBM26652; 5-Arylidene-3-benzylhydantoin, 29c-1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(5E)-1-Benzyl-5-[(2-methoxyphenyl)methylidene]imidazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL496973
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(5Z)-3-(2-Fluorobenzyl)-5-(4-fluorobenzylidene)-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL496994; SCHEMBL2548399; thiazolidine-2,4-dione, 19a; BDBM26641; STL368645; ZINC20494994; AKOS003407472; (5Z)-3-[(2-fluorophenyl)methyl]-5-[(4-fluorophenyl)methylidene]-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(5E)-1-Benzyl-5-[(4-ethoxyphenyl)methylidene]imidazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL496971
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(2-Fluorobenzyl)-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BAS 07786895; CHEMBL506711; ZINC4498572; STL370236; AKOS000348948; MCULE-7964484038; CS-0118417; SR-01000322937; SR-01000322937-1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(5E)-1-Benzyl-5-[[4-(dimethylamino)phenyl]methylidene]imidazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(5E)-1-benzyl-5-{[4-(dimethylamino)phenyl]methylidene}imidazolidine-2,4-dione; CHEMBL496972; SCHEMBL2545538; BDBM26653; 5-Arylidene-3-benzylhydantoin, 30c
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Galloyl tyramine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL258248
Click to Show/Hide
|
||||
| Activity |
IC50 = 161000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. J Med Chem. 2009 Jan 8;52(1):74-86. | ||||
| REF 2 | Pim2 inhibitors from the Papua New Guinean plant Cupaniopsis macropetala. J Nat Prod. 2008 Mar;71(3):451-2. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.