Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T11843 | Target Info | |||
| Target Name | Vitamin K epoxide reductase complex 1 (VKORC1) | ||||
| Synonyms |
Vitamin K1 2,3-epoxide reductase subunit 1; VKORC1; VKOR; UNQ308/PRO351; MSTP576; MSTP134
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| Target Type | Successful Target | ||||
| Gene Name | VKORC1 | ||||
| Biochemical Class | Short-chain dehydrogenases reductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Diethyl 2-[1-(4-hydroxy-2-oxochromen-3-yl)ethylidene]propanedioate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2048084; BDBM50386852
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| Activity |
Ki = 68900 nM
|
[1] | |||
| Compound Name |
4-Hydroxy-3-[2-(3-methylanilino)-1,3-thiazol-4-yl]chromen-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2048092; BDBM50386850
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| Activity |
Ki = 74200 nM
|
[1] | |||
| Compound Name |
4-Hydroxy-3-[2-(3-nitroanilino)-1,3-thiazol-4-yl]chromen-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2048096; BDBM50386851
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| Activity |
Ki = 79600 nM
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[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Biochemical and pharmacological evaluation of 4-hydroxychromen-2-ones bearing polar C-3 substituents as anticoagulants. Eur J Med Chem. 2012 Aug;54:144-58. | ||||
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