Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T16308 | Target Info | |||
| Target Name | Rotamase Pin1 (PIN1) | ||||
| Synonyms |
Prolyl isomerase Pin1; Peptidyl-prolyl cis-trans isomerase Pin1; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl prolyl cis/trans isomerase Pin1; PPIase Pin1
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| Target Type | Clinical trial Target | ||||
| Gene Name | PIN1 | ||||
| Biochemical Class | Cis-trans-isomerase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 88 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-acetyl-11-keto-beta-boswellic acid
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|
Investigative | Compound Info | ||
| Synonyms |
AKBA; 67416-61-9; 3-O-Acetyl-11-keto-beta-Boswellic Acid; AKbetaBA; UNII-BS16QT99Q1; Acetyl-11-keto-beta-boswellic acid; CHEMBL237111; BS16QT99Q1; Acetyl-11-keto--boswellic acid; AKBA cpd; Acetyl-11-keto-b-boswellic acid; acetyl-11-ketoboswellic acid; Acetyl-11-keto-beta-Boswellic Acid, Boswellia serrata; 3-Acetyl-11-keto-; 3alpha-acetoxy-11-keto-beta-boswellic acid; Curator_000001; MolPort-020-005-785; HMMGKOVEOFBCAU-BCDBGHSCSA-N
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|
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| Activity |
IC50 = 50360 nM
|
[1] | |||
| Compound Name |
2-phenyl-1H-imidazole-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
2-Phenyl-1H-imidazole-4-carboxylic acid; 77498-98-7; 2-phenyl-1H-imidazole-5-carboxylic acid; 1H-Imidazole-5-carboxylic acid, 2-phenyl-; CHEMBL1232889; 1H-Imidazole-4-carboxylic acid, 2-phenyl-; UNII-HGH57KDY8T; HGH57KDY8T; 2-phenylimidazole-4-carboxylic acid; G14; 2-phenyl-3H-imidazole-4-carboxylic Acid; AC1MC8EL; SCHEMBL1080850; CTK4I4538; CTK2I0991; XCAXKZJNJCKTQH-UHFFFAOYSA-N; MolPort-000-146-264; HMS3604D08; ZINC164985; CS-D0591; ALBB-012261; CP-011; BDBM50329857; STK897779; ANW-57703; AKOS007930827; AKOS005173647; NE61009
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|
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| Activity |
IC50 = 180000 nM
|
[2] | |||
| Compound Name |
(R)-2-(2-Naphthamido)-3-(3-cyanophenyl)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091467; BDBM50314712
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(R)-2-(Benzo[b]thiophene-2-carboxamido)-5-phenylpent-4-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091059; SCHEMBL16550485; SCHEMBL16550486; BDBM50314707; (E,2R)-2-(1-benzothiophene-2-carbonylamino)-5-phenylpent-4-enoic acid
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Pipecolate deriv., 9
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL566393; BDBM34001
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|
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| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
(R)-2-(2-Naphthamido)-3-(3-(trifluoromethyl)phenyl)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091805; BDBM50314682
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(2R)-5-(Azocan-1-yl)-5-oxo-2-[(2-phenyl-1,3-thiazole-4-carbonyl)amino]pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633027; BDBM50133479
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
(R)-2-(2-Naphthamido)-5-(3-fluorophenyl)pent-4-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090715; SCHEMBL16550471; SCHEMBL16550473; BDBM50314706; (E,2R)-5-(3-fluorophenyl)-2-(naphthalene-2-carbonylamino)pent-4-enoic acid
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(R)-2-(2-Naphthamido)-5-(3-fluorophenyl)pent-4-ynoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090379; SCHEMBL16550479; BDBM50314701; (2R)-5-(3-fluorophenyl)-2-(naphthalene-2-carbonylamino)pent-4-ynoic acid
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(R)-N-(2-(4-Fluorophenyl)-1-(1H-tetrazol-5-yl)ethyl)-2-naphthamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089033; BDBM50314696
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Ac-Lys(N-epsilon-biotinoyl)-Ala-Ala-Bth-Thr(PO3H2)-Pro-ChaGln-NH2
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL440637; BDBM50184833
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|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(R)-2-(2-Naphthamido)-5-cyclohexenylpent-4-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091060; BDBM50314708
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(R)-2-(2-Naphthamido)-3-(3,4-difluorophenyl)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1093045; BDBM50314686
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(R)-2-(2-Naphthamido)-5-(thiophen-2-yl)pent-4-ynoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089008; SCHEMBL16550493; BDBM50314703; (2R)-2-(naphthalene-2-carbonylamino)-5-thiophen-2-ylpent-4-ynoic acid
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(R)-N-(1-(1H-Tetrazol-5-yl)-2-(4-(trifluoromethyl)phenyl)ethyl)-2-naphthamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089034; BDBM50314697
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(R)-2-(2-Naphthamido)-5-(2-hydroxyphenyl)pent-4-ynoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090380; SCHEMBL16550470; BDBM50314702; (2R)-5-(2-hydroxyphenyl)-2-(naphthalene-2-carbonylamino)pent-4-ynoic acid
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(R)-3-(2-Naphthamido)-4-(3,4-difluorophenyl)butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1093343; BDBM50314687
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(R)-2-(2-Naphthamido)-3-(3,4-dichlorophenyl)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1093344; BDBM50314688
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(R)-3-(2-Naphthamido)-4-(3-chlorophenyl)butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089685; BDBM50314685
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(R)-2-(2-Naphthamido)-3-(3,4,5-trifluorophenyl)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1093345; BDBM50314689
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(R)-3-(2-Naphthamido)-4-(3-cyanophenyl)butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091804; BDBM50314713
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(R)-3-(2-Naphthamido)-4-(3-(trifluoromethyl)phenyl)butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091322; BDBM50314683
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Ac-Lys(N-epsilon-biotinoyl)-Ala-Ala-Nal-Thr(PO3H2)-Pro-tBuGly-Gln-NH2
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL267945; BDBM50184832
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|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(R)-3-(2-Naphthamido)-4-(3-fluorophenyl)butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091063; BDBM50314709
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Ac-Lys(N-epsilon-biotinoyl)-Ala-Ala-Nal-Thr(PO3H2)-Pro-Cha-Gln-NH2
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL218960; BDBM50184839
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|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(2R)-5-(Cyclooctylamino)-5-oxo-2-[(2-phenyl-1,3-thiazole-4-carbonyl)amino]pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633028; BDBM50133478
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
(R)-2-(2-Naphthamido)-3-(4-cyanophenyl)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089698; BDBM50314690
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(R)-2-(2-Naphthamido)-3-(3-chlorophenyl)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091827; BDBM50314684
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-(6-Nitro-2-(3-phenethylureido)quinazolin-4-ylamino)benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1774793; BDBM50343859
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|
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| Activity |
IC50 = 52500 nM
|
[7] | |||
| Compound Name |
N-[(2R)-3-(3-Fluorophenyl)-1-(methanesulfonamido)-1-oxopropan-2-yl]naphthalene-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089369; BDBM50314699; (R)-N-(3-(3-fluorophenyl)-1-(methylsulfonamido)-1-oxopropan-2-yl)-2-naphthamide
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|
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| Activity |
Ki = 53000 nM
|
[3] | |||
| Compound Name |
2-[4-(1-Benzothiophene-3-carbonylamino)-2-(3,4-dimethoxybenzoyl)anilino]-2-oxoacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2017126; SCHEMBL16550480; BDBM50381010
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|
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| Activity |
IC50 = 53550 nM
|
[8] | |||
| Compound Name |
4-(2-(3-Cyclohexylureido)-6-nitroquinazolin-4-ylamino)benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1774794; BDBM50343860
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|
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| Activity |
IC50 = 54200 nM
|
[7] | |||
| Compound Name |
2-[4-(1-Benzothiophene-2-carbonylamino)-2-(3,4-dimethoxybenzoyl)anilino]-2-oxoacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2017125; SCHEMBL16550510; BDBM50381009
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|
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| Activity |
IC50 = 54330 nM
|
[8] | |||
| Compound Name |
(R)-N-(3-(3-Fluorophenyl)-1-oxo-1-(thiazol-2-ylamino)propan-2-yl)-2-naphthamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089035; BDBM50314698
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|
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| Activity |
Ki = 57000 nM
|
[3] | |||
| Compound Name |
3-[(2S,5S,8S,11S,14S,17R,20S)-14,20-Bis(3-amino-3-oxopropyl)-5-benzyl-11-[(2S)-butan-2-yl]-4,7,8,17-tetramethyl-3,6,9,12,15,18,21-heptaoxo-1,4,7,10,13,16,19-heptazacyclohenicos-2-yl]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1076797; BDBM50481979
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|
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| Activity |
IC50 = 63000 nM
|
[9] | |||
| Compound Name |
(R)-2-(2-Naphthamido)-3-(2-fluorophenyl)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089942; BDBM50314718
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|
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| Activity |
Ki = 63000 nM
|
[3] | |||
| Compound Name |
6-Methyl-1H-benzimidazole-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
6-Methyl-1H-benzoimidazole-2-carboxylic acid; 5-methyl-1H-benzo[d]imidazole-2-carboxylic acid; CHEMBL596008; 5-methyl-1H-benzimidazole-2-carboxylic acid; 5-methylbenzimidazole-2-carboxylic acid; 1H-Benzimidazole-2-carboxylicacid,6-methyl-; 1H-Benzimidazole-2-carboxylic acid, 5-methyl-; 1H-BENZIMIDAZOLE-2-CARBOXYLIC ACID, 6-METHYL-; SCHEMBL2214853; CTK3I5749; DTXSID90363979; ALBB-012415; ZINC4384368; BBL002295; BDBM50305665; MFCD03368381; SBB071738; STK895029; AKOS000506106; AKOS003277880; AB29997; MCULE-1968751814; NCGC00327754-01; AB0180507; BB 0241007; R9410; ST45026926; 1h-benzimidazole-2-carboxylic acid,5-methyl-; 1H-Benzimidazole-2-carboxylicacid, 6-methyl-; 5-methyl-1h-benzoimidazole-2-carboxylic acid; 6-Methyl-1H-benzoimidazole-2-carboxylic acid; Y-2555; 5-methyl-1H-1,3-benzodiazole-2-carboxylic acid; AB01323381-02; A846030; 6-METHYL-1H-1,3-BENZODIAZOLE-2-CARBOXYLIC ACID; 6-Methyl-1H-benzoimidazole-2-carboxylic acid, AldrichCPR
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| Activity |
IC50 = 63000 nM
|
[10] | |||
| Compound Name |
(2R)-4-(Cyclohexylamino)-2-[(2-methyl-5-phenylpyrazole-3-carbonyl)amino]-4-oxobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633016; BDBM50133490
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| Activity |
IC50 = 67000 nM
|
[5] | |||
| Compound Name |
(2R)-5-(Cyclohexylamino)-2-[(2-methyl-5-phenylpyrazole-3-carbonyl)amino]-5-oxopentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633006; BDBM50133585
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| Activity |
IC50 = 77000 nM
|
[5] | |||
| Compound Name |
(R)-3-(1H-Benzo[d]imidazol-2-yl)-2-propionamidopropanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL593178; BDBM50305670
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| Activity |
IC50 = 78000 nM
|
[10] | |||
| Compound Name |
4-(Methylcarbamoyl)-2-phenyl-1H-imidazole-5-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1269225; SCHEMBL22479976; BDBM50329864
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| Activity |
IC50 = 80000 nM
|
[2] | |||
| Compound Name |
(2R)-2-[(2-Methyl-5-phenylpyrazole-3-carbonyl)amino]-4-(4-methylpiperidin-1-yl)-4-oxobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633013; BDBM50133502
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| Activity |
IC50 = 81000 nM
|
[5] | |||
| Compound Name |
(2R)-5-Morpholin-4-yl-2-(naphthalene-2-carbonylamino)-5-oxopentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633020; BDBM50133486
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|
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| Activity |
IC50 = 83000 nM
|
[5] | |||
| Compound Name |
(2R)-4-(1-Adamantylamino)-2-[(2-methyl-5-phenylpyrazole-3-carbonyl)amino]-4-oxobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633018; BDBM50133488
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|
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| Activity |
IC50 = 91000 nM
|
[5] | |||
| Compound Name |
(2R)-2-(1-Benzofuran-2-carbonylamino)-5-morpholin-4-yl-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633021; BDBM50133485
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|
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| Activity |
IC50 = 91000 nM
|
[5] | |||
| Compound Name |
(R)-Methyl 3-(1H-benzo[d]imidazol-2-yl)-2-(5-(4-methoxyphenyl)-2-methylfuran-3-carboxamido)propanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL593070; BDBM50305676
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|
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| Activity |
IC50 = 92000 nM
|
[10] | |||
| Compound Name |
(R)-2-(2-Naphthamido)-3-(2-(trifluoromethyl)phenyl)propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090075; BDBM50314717
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|
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| Activity |
Ki = 93000 nM
|
[3] | |||
| Compound Name |
(2R)-5-(Azepan-1-yl)-2-[(2-methyl-5-phenylpyrazole-3-carbonyl)amino]-5-oxopentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633001; BDBM50133590
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|
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(2R)-5-(1-Adamantylamino)-2-[(2-methyl-5-phenylpyrazole-3-carbonyl)amino]-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633008; BDBM50133514
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|
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(2R)-5-(Cyclopentylamino)-2-[(2-methyl-5-phenylpyrazole-3-carbonyl)amino]-5-oxopentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633005; BDBM50133586
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|
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(2R)-2-[(2-Methyl-5-phenylpyrazole-3-carbonyl)amino]-5-(4-methylpiperidin-1-yl)-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633003; BDBM50133588
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|
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Chembl4226887
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Investigative | Compound Info | ||
| Synonyms |
BDBM50461122
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
2-Chloro-N-cyclohexyl-5-nitropyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4226104; SCHEMBL8301782; SCHEMBL14026744; ZINC4243356; BDBM50461106; AKOS002663728; 2-chloro-4-cyclohexylamino-5-nitropyrimidine
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Chembl4225916
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL14841617; BDBM50461105; N-Phenethyl-2-chloro-5-nitropyrimidine-4-amine
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(2R)-2-[(2-Methyl-5-phenylpyrazole-3-carbonyl)amino]-4-oxo-4-pyrrolidin-1-ylbutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633009; BDBM50133513
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Chembl4228192
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Investigative | Compound Info | ||
| Synonyms |
BDBM50461111
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Chembl4226020
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Investigative | Compound Info | ||
| Synonyms |
BDBM50461120
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(2R)-4-(Cyclopentylamino)-2-[(2-methyl-5-phenylpyrazole-3-carbonyl)amino]-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633015; BDBM50133491
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Chembl4225606
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461115
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
2-Chloro-N-methyl-5-nitropyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-Chloro-4-(methylamino)-5-nitropyrimidine; (2-Chloro-5-nitro-pyrimidin-4-yl)-methyl-amine; CHEMBL4226348; 4-Pyrimidinamine,2-chloro-N-methyl-5-nitro-; ACMC-20lkcf; SCHEMBL4867295; CTK5G2780; DTXSID60428069; ZINC4243350; BDBM50461121; MFCD07440210; AKOS000320554; AB42030; MCULE-5454340632; 2-chloro-4-methylamino-5-nitropyrimidine; SY038666; 2-chloro-4-methylamino-5-nitro-pyrimidine; 2-chloro-N-methyl-5-nitro-4-pyrimidinamine; CS-0045735; 2-chloro-4-(methyl-amino)-5-nitropyrimidine; L-4062; 2-chloranyl-N-methyl-5-nitro-pyrimidin-4-amine; A843117; AN-584/43493899; N-(2-chloro-5-nitro-4-pyrimidinyl)-N-methylamine; F2124-0142
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(2R)-5-(Cycloheptylamino)-2-[(2-methyl-5-phenylpyrazole-3-carbonyl)amino]-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633007; BDBM50133584
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
3-(2-(3-(3,4-Dichlorophenyl)ureido)-6-nitroquinazolin-4-ylamino)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1774795; BDBM50343861
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
Chembl4227407
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461124
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(2R)-2-[(2-Methyl-5-phenylpyrazole-3-carbonyl)amino]-4-morpholin-4-yl-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633014; BDBM50133492
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(2R)-2-[(2-Methyl-5-phenylpyrazole-3-carbonyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633010; BDBM50133511
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-(4-Acetamido-2-benzoylanilino)-2-oxoacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2017124; BDBM50381008
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(2R)-4-(Azepan-1-yl)-2-[(2-methyl-5-phenylpyrazole-3-carbonyl)amino]-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633011; BDBM50133510
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Chembl4226558
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461112
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Chembl4227356
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461123; AKOS017626201
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(2R)-4-(Cycloheptylamino)-2-(naphthalene-2-carbonylamino)-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633023; BDBM50133483
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Chembl4227941
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461110
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(2R)-2-[(2-Methyl-5-phenylpyrazole-3-carbonyl)amino]-5-oxo-5-piperidin-1-ylpentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633000; BDBM50133591
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Chembl4227405
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461094
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(2R)-4-(Cyclohexylamino)-4-oxo-2-[(2-phenyl-1,3-thiazole-4-carbonyl)amino]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633029; BDBM50133477
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-Chloro-N-cyclopentyl-5-nitropyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(2-Chloro-5-nitro-pyrimidin-4-yl)-cyclopentyl-amine; CHEMBL1241353; SCHEMBL382894; ZINC4243384; BDBM50461093; AKOS002663661; CS-W004476; MCULE-1779675094; DB-122125; 2-chloro-4-cyclopentylamino-5-nitropyrimidine; L-3315; 2-Chloro-4-(cyclopentylamino)-5-nitropyrimidine; (2-Chloro-5-nitropyrimidin-4-yl)cyclopentylamine; 2-Chloro-N-cyclopentyl-5-nitro-pyrimidin-4-amine; (2-chloro-5-nitro-pyrimidine-4-yl)-cyclopentyl-amine; F2124-0154
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(2R)-2-(1-Benzofuran-2-carbonylamino)-4-(cycloheptylamino)-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633024; BDBM50133482
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Chembl4228140
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461113
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(2R)-2-[(2-Methyl-5-phenylpyrazole-3-carbonyl)amino]-5-oxo-5-(1H-pyrrol-2-yl)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3632999; BDBM50133592
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Chembl4224906
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461103
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(2R)-2-[(2-Methyl-5-phenylpyrazole-3-carbonyl)amino]-4-(3-methylpiperidin-1-yl)-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633012; BDBM50133509
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2,5-Dichloro-4-phenoxypyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4228271; BDBM50461129; ZINC86621729; AKOS018189935
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Chembl4227088
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461109
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Chembl4227732
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461107
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(2R)-4-(Cyclooctylamino)-4-oxo-2-[(2-phenyl-1,3-thiazole-4-carbonyl)amino]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633032; BDBM50133474
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Chembl4225874
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461125
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(+/-)-2-(2-Naphthamido)-3-(2,3-difluorophenyl)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090718; BDBM50314720
Click to Show/Hide
|
||||
| Activity |
Ki = 103000 nM
|
[3] | |||
| Compound Name |
(R)-3-(2-Naphthamido)-4-(4-(trifluoromethyl)phenyl)butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1093714; BDBM50314692
Click to Show/Hide
|
||||
| Activity |
Ki = 121000 nM
|
[3] | |||
| Compound Name |
4-(Ethylcarbamoyl)-2-phenyl-1H-imidazole-5-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1269226; SCHEMBL22479979; BDBM50329865
Click to Show/Hide
|
||||
| Activity |
IC50 = 140000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 14 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
cycloheximide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
naramycin A; NSC 185; FT 3422-2; NM-MCD 80
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[12] | |||
| Compound Name |
4-(Benzylcarbamoyl)-2-phenyl-1H-imidazole-5-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1271920; SCHEMBL22479980; BDBM50329866
Click to Show/Hide
|
||||
| Activity |
IC50 = 220000 nM
|
[2] | |||
| Compound Name |
2-(3-Methoxyphenyl)-5-methyl-1H-imidazole-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1269199; BDBM50329863; ZINC38078069; AKOS010257446; MCULE-3704324669; NE34106
Click to Show/Hide
|
||||
| Activity |
IC50 = 270000 nM
|
[2] | |||
| Compound Name |
3-[(3R,6S,9S,12S,15S,18S,21S,24S)-6,9,15,18-Tetrakis[3-(diaminomethylideneamino)propyl]-3-[(1R)-1-hydroxyethyl]-21-(naphthalen-2-ylmethyl)-2,5,8,11,14,17,20,23-octaoxo-1,4,7,10,13,16,19,22-octazabicyclo[22.4.0]octacosan-12-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089955; BDBM50481982
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[9] | |||
| Compound Name |
3-[(3R,6R,9R,12S,15R,18R,21R,24R,27S,30S)-6,9,15,18,21,24-Hexakis[3-(diaminomethylideneamino)propyl]-3-[(1R)-1-hydroxyethyl]-27-(naphthalen-2-ylmethyl)-2,5,8,11,14,17,20,23,26,29-decaoxo-1,4,7,10,13,16,19,22,25,28-decazabicyclo[28.4.0]tetratriacontan-12-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089954; BDBM50481986
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[9] | |||
| Compound Name |
[(1R)-1-[(3R,6R,9R,12S,15S,18S,21S)-12-(3-Amino-3-oxopropyl)-6,9,15-tris[3-(diaminomethylideneamino)propyl]-18-(naphthalen-2-ylmethyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazabicyclo[19.3.0]tetracosan-3-yl]ethyl] dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089953; BDBM50481988
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[9] | |||
| Compound Name |
(R)-2-(2-Naphthamido)-3-(2-cyanophenyl)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1093029; BDBM50314719
Click to Show/Hide
|
||||
| Activity |
Ki = 351000 nM
|
[3] | |||
| Compound Name |
5-Methyl-2-phenyl-1H-imidazole-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-methyl-2-phenyl-1H-imidazole-5-carboxylic acid; CHEMBL1230279; 1H-Imidazole-5-carboxylicacid, 4-methyl-2-phenyl-; EINECS 249-261-4; 5-methyl-2-phenyl-1H-imidazole-4-carboxylicacid; 5-methyl-2-phenyl-3H-imidazole-4-carboxylic acid; SCHEMBL316552; CTK1A6779; CTK8D4735; DTXSID30183017; ALBB-012398; ZINC5116121; BDBM50329858; MFCD09055144; AKOS005173585; AKOS015842176; MCULE-5941710551; NCGC00333031-01; SC-32592; DB-068008; BB 0253853; FT-0719940; EN300-58002; Y-3780; Z-1798; AB01328654-02; 2-Phenyl-4-methyl-1H-imidazole-5-carboxylic acid; 1H-Imidazole-4-carboxylic acid, 5-methyl-2-phenyl-; 1H-Imidazole-5-carboxylic acid, 4-methyl-2-phenyl-; Q27454671; F8889-9229; 4-Methyl-2-phenyl-1H-imidazole-5-carboxylic acid, AldrichCPR
Click to Show/Hide
|
||||
| Activity |
IC50 = 360000 nM
|
[2] | |||
| Compound Name |
3-(1H-Indol-2-yl)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1H-Indole-2-propanoic acid; CHEMBL595027; 3-indolylpropionic acid; SCHEMBL606161; CTK1E9928; DTXSID30522649; 3-(1H-Indole-2-yl)propanoic acid; BDBM50305669; ZINC35569694; AKOS006280094; AG-205/37082052
Click to Show/Hide
|
||||
| Activity |
IC50 = 450000 nM
|
[10] | |||
| Compound Name |
6-Methyl-1H-indole-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
6-Methylindole-2-carboxylic acid; 1H-Indole-2-carboxylicacid, 6-methyl-; CHEMBL596007; SCHEMBL1144688; CTK0H2206; KS-00000FGK; DTXSID70390349; HMS1630E02; ACT09171; ALBB-032679; ZINC2582714; ANW-48397; BBL020943; BDBM50305666; MFCD02664477; SBB010573; STK893649; AKOS000118128; FS-2410; MCULE-8264158205; SB15196; NCGC00337851-01; AK-77187; BR-77187; SC-20916; 6-METHYL INDOLE-2-CARBOXYLIC ACID; AB0001750; 6-METHYL-1H-INDOLE-2-CARBOXYLICACID; BB 0216437; CS-0018975; FT-0677786; ST50294005; W3994; EN300-15104; S-5444; AB01329949-02; 6-Methyl-1H-indole-2-carboxylic acid, AldrichCPR; J-518910; Q27454576; Z197513748
Click to Show/Hide
|
||||
| Activity |
IC50 = 630000 nM
|
[10] | |||
| Compound Name |
5-Pyridin-2-yl-1H-pyrazole-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-pyridin-2-yl-1H-pyrazole-5-carboxylic acid; 5-(pyridin-2-yl)-1H-pyrazole-3-carboxylic acid; 5-Pyridin-2-yl-2H-pyrazole-3-carboxylic acid; 3-(pyridin-2-yl)-1H-pyrazole-5-carboxylic acid; 1H-PYRAZOLE-3-CARBOXYLIC ACID, 5-(2-PYRIDINYL)-; CHEMBL1234945; 3-(2-PYRIDINYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID; 3-(2-pyridyl)pyrazole-5-carboxylic acid; MLS000039592; 5-(2-Pyridyl)-3-pyrazolecarboxylicAcid; SCHEMBL1528412; CTK1C2183; CTK7I5935; KS-00000CER; DTXSID70349832; HMS2421F07; ACT01639; ZINC2544993; ANW-54365; BBL008307; BDBM50329856; HTS028182; MFCD05170030; MFCD06245341; RW2312; SBB010786; STK741341; AKOS000148205; AKOS000302965; AB21564; CCG-122392; MCULE-2291154739; PS-8413; AK-17510; BR-17510; SC-35328; SMR000035087; SY004181; AB0019623; DB-014539; AM20070137; BB 0259299; BB 0310253; CS-0019168; FT-0647087; ST50109048; T7756; V0032; S-3703; 5-(2-PYRIDYL)-3-PYRAZOLECARBOXYLIC ACID; 064P025; 1H-Pyrazole-3-carboxylicacid, 5-(2-pyridinyl)-; 3-(pyridine-2-yl)-1H-pyrazole-5-carboxylic acid; J-517935; Q27464098; Z57683716; 5-(2-PYRIDINYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID; F1727-0247; 5-Pyridin-2-yl-1H-pyrazole-3-carboxylic acid, AldrichCPR
Click to Show/Hide
|
||||
| Activity |
IC50 = 720000 nM
|
[2] | |||
| Compound Name |
Procodazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-Benzimidazolepropionic acid; 3-(1H-Benzimidazol-2-yl)propanoic acid; 1H-Benzimidazole-2-propanoic acid; Procodazol; Propazol; UNII-SG5IU7FD3R; NSC35790; NSC 35790; 3-(1H-Benzoimidazol-2-yl)-propionic acid; 3-(1H-benzo[d]imidazol-2-yl)propanoic acid; 3-(1H-1,3-Benzodiazol-2-Yl)Propanoic Acid; SG5IU7FD3R; Propionic acid, 2-(2-benzimidazolyl)-; CHEMBL596009; 2-Benzimidazolepropionic acid, 97%; NSC-35790; Propazol;2-Benzimidazolepropionic acid; NCGC00013414-03; DSSTox_CID_25093; DSSTox_RID_80666; DSSTox_GSID_45093; Procodazole [INN]; 3-benzimidazol-2-ylpropanoic acid; Procodazolum; Propazole; Procodazol [INN-Spanish]; Procodazolum [INN-Latin]; 2-(2-Carboxyethyl)benzimidazole; beta-(2-Benzimidazole)propionic acid; beta-(2-Benzimidazolyl)propionic acid; BRN 0156920; 2-BENZIMIDAZOLEPROPIONICACID; Estimulocel (Salt/Mix); NCIStruc1_000049; NCIStruc2_000216; Oprea1_461552; Oprea1_527552; 5-25-04-00311 (Beilstein Handbook Reference); SCHEMBL349966; 2-benzimidazole propionic acid; 2-benzimidazole-propionic acid; IFLab1_003962; DTXSID5045093; CTK4F1173; ZINC51581; HMS1423E02; HMS3264A18; Pharmakon1600-01506175; ALBB-016689; HY-B1056; NCI35790; Tox21_110025; 7893AD; BBL004542; BDBM50305668; CCG-36559; MFCD00041215; NCGC00013414; NSC760399; s4408; SBB013216; STK387005; AKOS000200796; Tox21_110025_1; AL-1241; CS-4578; MCULE-3731847757; NSC-760399; .beta.-(2-Benzimidazole)propionic acid; Propionic acid, 3-(2-benzimidazolyl)-; .beta.-(2-Benzimidazolyl)propionic acid; NCGC00013414-02; NCGC00013414-04; NCGC00096529-01; NCGC00096529-02; BP-13182; CS-10157; NCI60_003248; TS-02680; 1H-Benzimidazole-2-propanoic acid (9CI); 3-(1H-benzimidazol-1-ium-2-yl)propanoate; 3-(1H-Benzimidazol-2-yl)propanoic acid #; AB0167251; Et2-N-4,5,6,7-4HBzthiophene carboxylate; ST4032782; BB 0219682; FT-0688794; SW219817-1; EN300-13260; L-5245; AB00442573-04; AB00442573_05; AB00442573_06; SR-01000944283; J-640101; J-800103; SR-01000944283-1; BRD-K54824716-001-01-6; Q27289198; Z57115077; F0852-0156
Click to Show/Hide
|
||||
| Activity |
IC50 = 740000 nM
|
[10] | |||
| Compound Name |
5-(2-Methoxyphenyl)-2-furoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
5-(2-methoxyphenyl)furan-2-carboxylic acid; CHEMBL372832; 5-(2-METHOXYPHENYL)-FURANE-2-CARBOXYLIC ACID; 5-(2-Methoxy-phenyl)-furan-2-carboxylic acid; SMR000033603; MLS000047592; SCHEMBL5842967; CTK4J9348; DTXSID10354561; HMS2310N08; HMS3604M16; KUC100868N; KUC100902N; KUC100909N; ZINC265874; BDBM50175430; MFCD02112922; AKOS002134633; DB07407; MCULE-2631078451; NCGC00051553-02; BB 0222510; EU-0033228; X5441; SR-01000597060; SR-01000597060-1; Q27096628; Z2581547733
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Compound Name |
N-Ethyl-5-methyl-1H-benzo[d]imidazole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL595026; BDBM50305667
Click to Show/Hide
|
||||
| Activity |
IC50 > 2000000 nM
|
[10] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
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| REF 2 | Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6483-8. | ||||
| REF 3 | Structure-based design of novel human Pin1 inhibitors (II). Bioorg Med Chem Lett. 2010 Apr 1;20(7):2210-4. | ||||
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| REF 5 | Peptidyl prolyl isomerase Pin1-inhibitory activity of D-glutamic and D-aspartic acid derivatives bearing a cyclic aliphatic amine moiety. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5619-24. | ||||
| REF 6 | Nanomolar inhibitors of the peptidyl prolyl cis/trans isomerase Pin1 from combinatorial peptide libraries. J Med Chem. 2006 Apr 6;49(7):2147-50. | ||||
| REF 7 | Synthesis and biological evaluation of novel quinazoline-derived human Pin1 inhibitors. Bioorg Med Chem. 2011 May 1;19(9):2797-807. | ||||
| REF 8 | Synthesis and biological evaluation of novel human Pin1 inhibitors with benzophenone skeleton. Bioorg Med Chem. 2012 May 1;20(9):2992-9. | ||||
| REF 9 | Membrane permeable cyclic peptidyl inhibitors against human Peptidylprolyl Isomerase Pin1. J Med Chem. 2010 Mar 25;53(6):2494-501. | ||||
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| REF 11 | Synthesis and biological evaluation of pyrimidine derivatives as novel human Pin1 inhibitors. Bioorg Med Chem. 2018 May 1;26(8):2186-2197. | ||||
| REF 12 | Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties. J Med Chem. 1999 Sep 9;42(18):3615-22. | ||||
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