Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T17345 | Target Info | |||
| Target Name | Dihydrofolate reductase (DHFR) | ||||
| Synonyms |
DYR; DHFRP1
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| Target Type | Successful Target | ||||
| Gene Name | DHFR | ||||
| Biochemical Class | CH-NH donor oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 72 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Pemetrexed
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|
Approved | Compound Info | ||
| Synonyms |
Alimta; LYA; LY 231514; LY231514; Alimta (TN); LY 231,514; LY-2315; LY-231514; Pemetrexed (INN); Pemetrexed [INN:BAN]; LY-231,514; N-(4-(2-(2-Amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimdin-5-yl)ethyl)benzoyl)glutamic acid; N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1h-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-d-glutamic acid; (2R)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid; (2S)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid; 2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid; 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID
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| Activity |
IC50 = 66000 nM
|
[1] | |||
| Compound Name |
CHALCONE
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Investigative | Compound Info | ||
| Synonyms |
Chalcone; (E)-Chalcone; trans-Chalcone; Benzalacetophenone; 614-47-1; 94-41-7; Benzylideneacetophenone; Chalkone; Phenyl styryl ketone; Cinnamophenone; 2-Benzalacetophenone; 2-Benzylideneacetophenone; 1,3-DIPHENYL-2-PROPEN-1-ONE; 1,3-Diphenylpropenone; (2E)-1,3-diphenylprop-2-en-1-one; Styryl phenyl ketone; 3-Phenylacrylophenone; 1-Benzoyl-2-phenylethene; trans-Benzalacetophenone; beta-Benzoylstyrene; Benzylidenecetophenone; Phenyl trans-styryl ketone; 2-Propen-1-one, 1,3-diphenyl-; 1-Benzoyl-1-phenylethene
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Abbott 14c
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Investigative | Compound Info | ||
| Synonyms |
2,4-diaminopyrimidine-based antagonist, 14c
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1-Cyclopropyl-7-[4-[[1-[(2,4-diaminopyrimidin-5-yl)methyl]triazol-4-yl]methyl]piperazin-1-yl]-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2012918; BDBM50380092
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|
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| Activity |
IC50 = 50000 nM
|
[4] | |||
| Compound Name |
2-{4-[(4-Amino-2-methyl-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL307137; BDBM50010936
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
5-[(2,4-Difluorophenoxy)methyl]quinazoline-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL251428; 5-((2,4-difluorophenoxy)methyl)quinazoline-2,4-diamine; SCHEMBL1154669; BDBM50232526
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
5-[(3-Fluorophenoxy)methyl]quinazoline-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4062544; BDBM50237209
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
PF-DcpSi
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4077061; BDBM50237199; J3.645.982D; 5-(3-Cyano-5-fluorophenoxymethyl)-2,4-diaminoquinazoline
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| Activity |
IC50 = 52000 nM
|
[6] | |||
| Compound Name |
2-Amino-5-(4-nitrophenylthio)-6-methyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400364; BDBM18807; Pyrrolo[2,3-d]pyrimidine analogue, 2; 2-amino-6-methyl-5-[(4-nitrophenyl)sulfanyl]-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-4-one
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| Activity |
IC50 ~ 54000 nM
|
[7] | |||
| Compound Name |
3-Chloro-N-(2,4-dioxo-3-oxatricyclo[7.3.1.05,13]trideca-1(12),5(13),6,8,10-pentaen-7-yl)-1-benzothiophene-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2323386; BDBM50426881
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| Activity |
Ki ~ 55000 nM
|
[8] | |||
| Compound Name |
5-((1-(3-Chlorobenzyl)piperidin-4-yl)methoxy)quinazoline-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL251430; SCHEMBL2165714; BDBM50232527; 5-[1-(3-chlorobenzyl)piperidin-4-ylmethoxy]quinazoline-2,4-diamine; 5-[[1-[(3-chlorophenyl)methyl]piperidin-4-yl]methoxy]quinazoline-2,4-diamine
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| Activity |
IC50 = 55200 nM
|
[9] | |||
| Compound Name |
2,4-Pyrimidinediamine, 6-methyl-5-(1-naphthalenyl)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL422095; 2,4-diamino-5-(1-naphthyl)-6-methylpyrimidine; CHEMBL137737; SCHEMBL6049517; CTK1F7515; DTXSID80480760; BDBM50028550; ZINC27429943; 6-methyl-5-naphthalen-1-ylpyrimidine-2,4-diamine; 6-METHYL-5-(NAPHTHALEN-1-YL)PYRIMIDINE-2,4-DIAMINE; 6-Methyl-5-naphthalen-1-yl-pyrimidine-2,4-diamine; methanol
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| Activity |
Ki = 56000 nM
|
[10] | |||
| Compound Name |
(E)-1-[4-(4,6-Diamino-2,2-dimethyl-1,3,5-triazin-1-yl)phenyl]-3-phenylprop-2-en-1-one;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3785981; BDBM50160596
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| Activity |
IC50 = 56400 nM
|
[2] | |||
| Compound Name |
2-Amino-6-phenyl-3,7-dihydropyrimido[4,5-b][1,4]oxazin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3228459; CTK1F3738; DTXSID20482046; BDBM50000045; 4H-Pyrimido[4,5-b][1,4]oxazin-4-one, 2-amino-1,7-dihydro-6-phenyl-
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| Activity |
IC50 = 57000 nM
|
[11] | |||
| Compound Name |
2-Amino-5-(3,4-dichlorophenylthio)-6-methyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL400485; BDBM18808; Pyrrolo[2,3-d]pyrimidine analogue, 3; 2-amino-5-[(3,4-dichlorophenyl)sulfanyl]-6-methyl-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-4-one
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| Activity |
IC50 ~ 62000 nM
|
[7] | |||
| Compound Name |
2,4-Diaminofuro[2,3-d]pyrimidine, 12
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL606362; BDBM33406
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| Activity |
IC50 = 62700 nM
|
[12] | |||
| Compound Name |
6-{[Prop-2-ynyl-(3,4,5-trimethoxy-phenyl)-amino]-methyl}-3H-quinazolin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL433059; SCHEMBL9823461; BDBM50015704; 6-[(3,4,5-trimethoxy-N-prop-2-ynylanilino)methyl]-1H-quinazolin-4-one; 6-[N-(3,4,5-Trimethoxyphenyl)-N-(2-propynyl)aminomethyl]quinazolin-4(3H)-one
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| Activity |
IC50 = 66600 nM
|
[13] | |||
| Compound Name |
4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62675; SCHEMBL9823208; BDBM50015703; 4-[(2-amino-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynylamino]benzonitrile; 4-[N-[(2-Amino-3,4-dihydro-4-oxoquinazolin)-6-ylmethyl]-N-(2-propynyl)amino]benzonitrile
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| Activity |
IC50 = 66600 nM
|
[13] | |||
| Compound Name |
1,1-Bis(3,5-dibromo-4-hydroxy-phenyl)benzo[e]isobenzofuran-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL214872; Phenolnaphthalein derivative, 5; 1,2-naphthalein derivative, 5; BDBM18759
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| Activity |
Ki = 69000 nM
|
[14] | |||
| Compound Name |
5-(4-Morpholin-4-YL-phenylsulfanyl)-2,4-quinazolinediamine
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Investigative | Compound Info | ||
| Synonyms |
5-{[4-(morpholin-4-yl)phenyl]sulfanyl}quinazoline-2,4-diamine; gw2021; CHEMBL328827; SCHEMBL4316405; BDBM18048; CTK7E0792; DB02001; 5-(4-Morpholinophenylthio)quinazoline-2,4-diamine; Q27093092; 5-[(4-morpholin-4-ylphenyl)sulfanyl]quinazoline-2,4-diamine; 5-{[4-(4-MORPHOLINYL)PHENYL]SULFANYL}-2,4-QUINAZOLINEDIAMIN
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| Activity |
IC50 = 70000 nM
|
[15] | |||
| Compound Name |
Chembl4227744
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Investigative | Compound Info | ||
| Synonyms |
BDBM50461752
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| Activity |
IC50 = 70510 nM
|
[16] | |||
| Compound Name |
Chembl4162075
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Investigative | Compound Info | ||
| Synonyms |
BDBM50290156; 6-[4-[(3-chlorophenyl)methoxy]phenyl]-1,3,5-triazine-2,4-diamine
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| Activity |
IC50 = 72490 nM
|
[17] | |||
| Compound Name |
4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL417562; SCHEMBL9823308; BDBM50015702; 4-[(2-amino-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynylamino]benzamide; 4-[N-[(2-Amino-3,4-dihydro-4-oxoquinazolin)-6-ylmethyl]-N-(2-propynyl)amino]benzamide
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| Activity |
IC50 = 72600 nM
|
[13] | |||
| Compound Name |
5-[[4-[5-Chloro-2-[[3-(trifluoromethyl)phenyl]methoxy]phenyl]piperazin-1-yl]methyl]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3972872; BDBM50203242
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| Activity |
IC50 ~ 75000 nM
|
[18] | |||
| Compound Name |
6-N-[(3,4,5-Trimethoxyphenyl)methyl]pyrido[2,3-d]pyrimidine-2,4,6-triamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL33208; SCHEMBL8196293; BDBM50051919; N''-(3,4,5-Trimethoxybenzyl)pyrido[2,3-d]pyrimidine-2,4,6-triamine; N*6*-(3,4,5-Trimethoxy-benzyl)-pyrido[2,3-d]pyrimidine-2,4,6-triamine; 2,4-Diamino-6-[N-(3',4',5'-trimethoxybenzy)amino]-pyrido[2,3-d]pyrimidine; N6-[(3,4,5-trimethoxyphenyl)methyl]pyrido[2,3-d]pyrimidine-2,4,6-triamine
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| Activity |
IC50 = 76000 nM
|
[19] | |||
| Compound Name |
2-[4-(7-Amino-9-oxo-8,9-dihydro-2,5,6,8-tetraaza-cyclopenta[a]naphthalen-2-yl)-benzoylamino]-pentanedioic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL331208; BDBM50003058
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| Activity |
IC50 ~ 80000 nM
|
[20] | |||
| Compound Name |
Chembl4169358
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Investigative | Compound Info | ||
| Synonyms |
6-[4-[(4-chlorophenyl)methoxy]phenyl]-1,3,5-triazine-2,4-diamine; SCHEMBL6977364; BDBM50290155
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| Activity |
IC50 = 83300 nM
|
[17] | |||
| Compound Name |
5-[2-(2-Methoxyphenyl)-4-methylpent-1-enyl]furo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL593154
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| Activity |
IC50 = 86500 nM
|
[12] | |||
| Compound Name |
2,4-Diaminofuro[2,3-d]pyrimidine, 11
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL594790; BDBM33405; D2F
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| Activity |
IC50 = 93900 nM
|
[12] | |||
| Compound Name |
1,8-Naphthalein derivative, 9
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL385296; BDBM18762
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| Activity |
Ki = 94000 nM
|
[14] | |||
| Compound Name |
7-Amino-1,2,3-trimethyl-2,8-dihydro-2,5,6,8-tetraaza-cyclopenta[a]naphthalen-9-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL122959; BDBM50003057; 3-Amino-2,8-dihydro-7,8,9-trimethyl-1H-pyrrolo[3',4':4,5]pyrido[2,3-d]pyrimidin-1-one
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| Activity |
IC50 ~ 95000 nM
|
[20] | |||
| Compound Name |
5-(3-Chlorobenzyloxy)quinazoline-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL250231; 5-[(3-chlorophenyl)methoxy]quinazoline-2,4-diamine; SCHEMBL1154353; BDBM50232566
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| Activity |
IC50 = 98000 nM
|
[9] | |||
| Compound Name |
2,4-Pyrimidinediamine, 5-[(3,4-dihydro-2(1H)-isoquinolinyl)methyl]-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL74782; ACMC-20lm8z; SCHEMBL9830129; CTK2J5717; DTXSID30631144; BDBM50128539; ZINC13520504; AKOS022452113; 5-(1,2,3,4-tetrahydroisoquinolin-2-ylmethyl)pyrimidine-2,4-diamine; 5-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-pyrimidine-2,4-diamine; 5-[(3,4-Dihydroisoquinolin-2(1H)-yl)methyl]pyrimidine-2,4-diamine; 5-(3,4-DIHYDRO-1H-ISOQUINOLIN-2-YLMETHYL)PYRIMIDINE-2,4-DIAMINE
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| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
10-[(4-Methoxyphenyl)methyl]-6,8,10-triazaspiro[4.5]deca-6,8-diene-7,9-diamine;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824526
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| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
10-[(4-Methylphenyl)methyl]-6,8,10-triazaspiro[4.5]deca-6,8-diene-7,9-diamine;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824525
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| Activity |
IC50 ~ 100000 nM
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[22] | |||
| Compound Name |
6-Ethyl-6-methyl-1-[(4-methylphenyl)methyl]-1,3,5-triazine-2,4-diamine;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824521
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| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
10-[(3,4-Dichlorophenyl)methyl]-6,8,10-triazaspiro[4.5]deca-6,8-diene-7,9-diamine;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824528
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| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
5-[(4-Methylphenyl)methyl]-1,3,5-triazaspiro[5.5]undeca-1,3-diene-2,4-diamine;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824529
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| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
6-[[(4-Acetylphenyl)-2-propynylamino]methyl]-4(3H)-quinazolinone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL64215; SCHEMBL9823134; BDBM50015696; 6-[(4-acetyl-N-prop-2-ynylanilino)methyl]-1H-quinazolin-4-one; 6-[N-(4-Acetylphenyl)-N-(2-propynyl)aminomethyl]quinazolin-4(3H)-one; 6-{[(4-Acetyl-phenyl)-prop-2-ynyl-amino]-methyl}-3H-quinazolin-4-one
Click to Show/Hide
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| Activity |
IC50 = 100000 nM
|
[13] | |||
| Compound Name |
(E)-3-[3-(4,6-Diamino-2,2-dimethyl-1,3,5-triazin-1-yl)phenyl]-1-phenylprop-2-en-1-one;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3787681; BDBM50160595
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
5-[(3,4,5-Trimethoxyphenyl)methyl]-1,3,5-triazaspiro[5.5]undeca-1,3-diene-2,4-diamine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824533
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| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
6-Ethyl-1-[(4-methoxyphenyl)methyl]-6-methyl-1,3,5-triazine-2,4-diamine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824522
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|
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| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
5-[(4-Methoxyphenyl)methyl]-1,3,5-triazaspiro[5.5]undeca-1,3-diene-2,4-diamine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824530
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| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
1-[(4-Chlorophenyl)methyl]-6-ethyl-6-methyl-1,3,5-triazine-2,4-diamine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824523
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|
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| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
6,6-Dimethyl-1-[(3,4,5-trimethoxyphenyl)methyl]-1,3,5-triazine-2,4-diamine;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824520
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|
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| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
5-[(4-Chlorophenyl)methyl]-1,3,5-triazaspiro[5.5]undeca-1,3-diene-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824532; CHEMBL1852785; BDBM50352137
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| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
(E)-3-[4-(4,6-Diamino-2,2-dimethyl-1,3,5-triazin-1-yl)phenyl]-1-phenylprop-2-en-1-one;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3785320; BDBM50160594
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-{4-[2-(2-Amino-4-hydroxy-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL170101; SCHEMBL14469100; BDBM50003896; NSC660025; NSC-660025; 5,6-Dideaza-5,6,7,8-tetrahydrofolic acid; FT-0670839
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| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
Chembl4229201
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Investigative | Compound Info | ||
| Synonyms |
BDBM50461759
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| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(2S)-2-[[4-[Acetyl-[(2,4-diamino-5-formyl-7,8-dihydro-6H-pyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]amino]pentanedioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2153712; BDBM50392649
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
5-[(3,4-Dichlorophenyl)methyl]-1,3,5-triazaspiro[5.6]dodeca-1,3-diene-2,4-diamine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824534
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
5-[7-Methoxy-4-(3-nitro-phenyl)-3,4-dihydro-1H-isoquinolin-2-ylmethyl]-pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL78104; BDBM50128538
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[21] | |||
| Compound Name |
5-[(4-Methylphenyl)methyl]-1,3,5-triazaspiro[5.6]dodeca-1,3-diene-2,4-diamine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824535
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
5-[(3,4-Dichlorophenyl)methyl]-1,3,5-triazaspiro[5.5]undeca-1,3-diene-2,4-diamine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
TCMDC-136304; CHEMBL535030
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
5-[(4-Fluorophenyl)methyl]-1,3,5-triazaspiro[5.5]undeca-1,3-diene-2,4-diamine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824531
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
1-[(4-Chlorophenyl)methyl]-6-cyclopropyl-6-methyl-1,3,5-triazine-2,4-diamine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824524
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
N-(4-((3-(2,4-Diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl)amino)benzoyl)glutamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
543U76; 5-DACTHF; 5,11-Methenyltetrahydrohomofolate; CHEMBL13659; 5-Deazacyclotetrahydrofolate; SCHEMBL9688062; DTXSID90922646; ZINC8642279; BDBM50005520
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
5-[(4-Chlorophenyl)methyl]-1,3,5-triazaspiro[5.5]undeca-1,3-diene-2,4-diamine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824532
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
10-[(4-Chlorophenyl)methyl]-6,8,10-triazaspiro[4.5]deca-6,8-diene-7,9-diamine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824527
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
3,3-Bis(3-fluoro-4-hydroxy-phenyl)benzo[g]isobenzofuran-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL411871; 1,2-naphthalein derivative, 8; BDBM18761
Click to Show/Hide
|
||||
| Activity |
Ki = 109000 nM
|
[14] | |||
| Compound Name |
5-(3,4-Dimethoxy-5-{(1e)-3-Oxo-3-[(1s)-1-Propylphthalazin-2(1h)-Yl]prop-1-En-1-Yl}benzyl)pyrimidine-2,4-Diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1235617; BDBM50335530; Q27464883
Click to Show/Hide
|
||||
| Activity |
IC50 = 110000 nM
|
[25] | |||
| Compound Name |
1,1-Bis(4-hydroxyphenyl)benzo[e]isobenzofuran-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386685; 1,2-naphthalein derivative, 1; BDBM18755; 3,3-bis(4-hydroxyphenyl)-4-oxatricyclo[7.4.0.0;{2,6}]trideca-1(9),2(6),7,10,12-pentaen-5-one
Click to Show/Hide
|
||||
| Activity |
Ki = 110000 nM
|
[14] | |||
| Compound Name |
3-(5-((2,4-Diaminopyrimidin-5-yl)methyl)-3-hydroxy-2-methoxyphenyl)-1-(1-propylphthalazin-2(1H)-yl)prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL560502; BAL-17662; BDBM50294211
Click to Show/Hide
|
||||
| Activity |
IC50 = 110000 nM
|
[26] | |||
| Compound Name |
N-(2,4-Dioxo-3-oxatricyclo[7.3.1.05,13]trideca-1(12),5(13),6,8,10-pentaen-7-yl)-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2323378; BDBM50426874
Click to Show/Hide
|
||||
| Activity |
Ki ~ 110000 nM
|
[8] | |||
| Compound Name |
5-{[1-(2-Fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251429; 5-((1-(2-fluorobenzyl)piperidin-4-yl)methoxy)quinazoline-2,4-diamine; SCHEMBL2164740; BDBM50232538; DB07642; NCGC00187878-01; J3.522.778D; D156844; D-156844; Q27096861
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[9] | |||
| Compound Name |
(3-Chlorophenyl)(4-((2,4-diaminoquinazolin-5-yloxy)methyl)piperidin-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL413990; SCHEMBL1154622; BDBM50232541; (3-chlorophenyl)-[4-[(2,4-diaminoquinazolin-5-yl)oxymethyl]piperidin-1-yl]methanone
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[9] | |||
| Compound Name |
(2-Chlorophenyl)-[4-(2,4-diaminoquinazolin-5-yloxymethyl)piperidin-1-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250075; SCHEMBL1154481; BDBM50232571; (2-chlorophenyl)(4-((2,4-diaminoquinazolin-5-yloxy)methyl)piperidin-1-yl)methanone; (2-chlorophenyl)-[4-[(2,4-diaminoquinazolin-5-yl)oxymethyl]piperidin-1-yl]methanone
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[9] | |||
| Compound Name |
5-((1-(2-Fluorophenylsulfonyl)piperidin-4-yl)methoxy)quinazoline-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251434; 5-[1-(2-fluorobenzenesulfonyl)piperidin-4-ylmethoxy]quinazoline-2,4-diamine; 5-(1-(2-Fluorobenzenesulfonyl)piperidin-4-ylmethoxy]quinazoline-2,4-diamine; SCHEMBL2165443; BDBM50232561; 5-[[1-(2-fluorophenyl)sulfonylpiperidin-4-yl]methoxy]quinazoline-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[9] | |||
| Compound Name |
5-(((2-Methylpyridin-3-yl)oxy)methyl)quinazoline-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4061457; BDBM50237211
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[6] | |||
| Compound Name |
2,4-Diamino-6-[N-(3',5'-dimethoxybenzyl)amino]pyrido-[2,3-d]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL32266; BDBM50051912; N*6*-(3,5-Dimethoxy-benzyl)-pyrido[2,3-d]pyrimidine-2,4,6-triamine; N6-[(3,5-dimethoxyphenyl)methyl]pyrido[2,3-d]pyrimidine-2,4,6-triamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 160000 nM
|
[27] | |||
| Compound Name |
6-Phenyl-7H-pyrimido[4,5-b][1,4]oxazine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3228468; BDBM50000053
Click to Show/Hide
|
||||
| Activity |
IC50 = 168000 nM
|
[11] | |||
| Compound Name |
5-(1,3,4,9-Tetrahydro-beta-carbolin-2-ylmethyl)-pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL75944; BDBM50128540
Click to Show/Hide
|
||||
| Activity |
IC50 = 180000 nM
|
[21] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 34 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Riluzole
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Rilutek; Riluzol; Riluzolum; Riluzole HCl; RP 54274; ALBB-006046; BF-37; PK-26124; R-116; RP-54274; Rilutek (TN); Riluzol [INN-Spanish]; Riluzole [USAN:INN]; Riluzolum [INN-Latin]; ZERO/001785; Amino-2 trifluoromethoxy-6 benzothiazole; Amino-2 trifluoromethoxy-6 benzothiazole [French]; Riluzole (JAN/USAN/INN); PK-26124, RP-54274, Rilutek, Riluzole; 2-Amino-6-(trifluoromethoxy)-benzothiazole; 2-Amino-6-(trifluoromethoxy)benzothiazole; 2-Amino-6-trifluoro-methoxybenzothiazole; 2-amino-6-(trifluoromethoxy)-1,3-benzothiazole; 2-amino-6-(trifluoromethoxy)benzo[d]thiazole; 2-amino-6-(trifluoromethoxyl)benzothiazole; 2-amino-6-trifluoromethoxybenzothiazole; 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine; 6-(trifluoromethoxy)benzo[d]thiazol-2-amine; 6-Trifluoromethoxy-benzothiazol-2-ylamine; 6-trifluoromethoxybenzothiazole-2-yl-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 312000 nM
|
[28] | |||
| Compound Name |
Trimetrexate
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
TMQ; Trimetrexato; Trimetrexatum; JB 11; Jb-11; Trimetrexato [INN-Spanish]; Trimetrexatum [INN-Latin]; Trimetrexate (USAN/INN); Trimetrexate [USAN:BAN:INN]; 2,4-Diamino-5-methyl-6-((3,4,5-trimethoxyanilino)methyl)quinazoline; 5-Methyl-6-(((3,4,5-trimethoxyphenyl)amino)methyl)-2,4-quinazolinediamine; 5-methyl-6-({[3,4,5-tris(methyloxy)phenyl]amino}methyl)quinazoline-2,4-diamine; 5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline-2,4-diamine; 6-[((3,4,5-Trimethoxyphenyl)amino)methyl]-5-methyl-2,4-quinazolinediamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 340000 nM
|
[19] | |||
| Compound Name |
Epiroprim
Click to Show/Hide
|
Terminated | Compound Info | ||
| Synonyms |
Epiroprim; Epiroprim [INN]; TCMDC-137295; 73090-70-7; Epiroprimum [INN-Latin]; Epiroprime [INN-French]; Epiroprima [INN-Spanish]; Ro 11-8958; UNII-9G69D95443; BRN 4273487; CHEMBL280378; C19H23N5O2; Ro-11-8958; 9G69D95443; 5-((3,5-Diethoxy-4-(1H-pyrrol-1-yl)phenyl)methyl)-2,4-pyrimidinediamine; Epiroprime; Epiroprimum; Epiroprima; 2,4-Diamino-5-(3,5-diethoxy-4-pyrrol-1-ylbenzyl)pyrimidine; 2,4-Pyrimidinediamine, 5-((3,5-diethoxy-4-(1H-pyrrol-1-yl)phenyl)methyl)-; Epir; AC1L2APS; SCHEMBL75698; AC1Q563X; DTXSID20223355; ZINC598590
Click to Show/Hide
|
||||
| Activity |
IC50 = 600000 nM
|
[29] | |||
| Compound Name |
flavin mononucleotide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
riboflavin 5'-phosphate; riboflavin 5'-monophosphate
Click to Show/Hide
|
||||
| Activity |
IC50 = 325000 nM
|
[30] | |||
| Compound Name |
2,4-Diamino-5-methyl-6-(3''-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598292; BDBM50310333
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[31] | |||
| Compound Name |
5-Methyl-6-(2-methyl-6-propan-2-ylphenyl)sulfanylfuro[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL611984; BDBM50310331; 2,4-Diamino-5-methyl-6-(2''-isopropyl-6''-methylphenylsulfanyl)-furo[2,3-d]pyrimidine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[31] | |||
| Compound Name |
2,4-Diamino-5-methyl-6-(2''-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598090; BDBM50310334
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[31] | |||
| Compound Name |
6-(2,5-Dimethoxyphenyl)sulfanyl-5-methylfuro[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL596681; BDBM50310337; 2,4-Diamino-5-methyl-6-(2'',5''-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[31] | |||
| Compound Name |
6-(2,6-Dichlorophenyl)sulfanyl-5-methylfuro[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL596680; BDBM50310327; 2,4-Diamino-5-methyl-6-(2'',6''-dichlorophenylsulfanyl)-furo[2,3-d]pyrimidine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[31] | |||
| Compound Name |
2,4-Diamino-5-methyl-6-(1-naphthylthio)furo[2,3-d]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602104; BDBM50310330
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[31] | |||
| Compound Name |
6-(3,4-Dimethoxyphenyl)sulfanyl-5-methylfuro[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598293; BDBM50310332; 2,4-Diamino-5-methyl-6-(3'',4''-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[31] | |||
| Compound Name |
2,4-Diamino-5-methyl-6-(4''-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597885; BDBM50310336
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[31] | |||
| Compound Name |
2,4-Diamino-5-methyl-6-(2-naphthylthio)furo[2,3-d]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL596673; BDBM50310329
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[31] | |||
| Compound Name |
6-(2,6-Dimethylphenyl)sulfanyl-5-methylfuro[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL609896; BDBM50310328; 2,4-Diamino-5-methyl-6-(2'',6''-dimethylphenylsulfanyl)-furo[2,3-d]pyrimidine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[31] | |||
| Compound Name |
5-Methyl-6-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]sulfanylfuro[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL604722; BDBM50310335
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[31] | |||
| Compound Name |
2-(4-{[(2,4-Diamino-furo[2,3-d]pyrimidin-5-ylmethyl)-amino]-methyl}-benzoylamino)-pentanedioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL106699; BDBM50030818; N-[4-[[[(2,4-Diaminofuro[2,3-d]pyrimidin-5-yl)methyl]amino]methyl]benzoyl]-L-glutamic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[32] | |||
| Compound Name |
2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-phosphono-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL38902; BDBM50005868
Click to Show/Hide
|
||||
| Activity |
IC50 = 220000 nM
|
[33] | |||
| Compound Name |
(2S)-2-{[4-({2-Amino-5-methyl-4-oxo-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-6-yl}sulfanyl)phenyl]formamido}pentanedioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL224974; BDBM18794; pyrrolo[2,3-d]pyrimidine scaffold, 4
Click to Show/Hide
|
||||
| Activity |
IC50 > 240000 nM
|
[34] | |||
| Compound Name |
2-Amino-6-methyl-3,7-dihydropyrimido[4,5-b][1,4]oxazin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3228460; BDBM50000046
Click to Show/Hide
|
||||
| Activity |
IC50 = 242000 nM
|
[11] | |||
| Compound Name |
1-Cyclopropyl-7-[4-[(2,4-diaminopyrimidin-5-yl)methoxymethyl]triazol-1-yl]-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2012916; BDBM50380096
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[4] | |||
| Compound Name |
1-Cyclopropyl-6-fluoro-4-oxo-7-(4-prop-2-ynylpiperazin-1-yl)-1,8-naphthyridine-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2012917; BDBM50380093
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[4] | |||
| Compound Name |
1-Cyclopropyl-6-fluoro-4-oxo-7-(prop-2-ynylamino)-1,8-naphthyridine-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2012914; BDBM50380094
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[4] | |||
| Compound Name |
3-(5-Amino-1,3,4-Thiadiazol-2-Yl)-1-Thiophen-2-Ylpropan-1-One
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650287; BDBM50335104; Q27467298; 3-(5-Amino-[1,3,4]thiadiazol-2-yl)-1-(thiophen-2-yl)propan-1-one; WHF
Click to Show/Hide
|
||||
| Activity |
IC50 = 300000 nM
|
[28] | |||
| Compound Name |
3-(2-Chloro-6-fluorophenyl)-N-(2,4-dioxo-3-oxatricyclo[7.3.1.05,13]trideca-1(12),5(13),6,8,10-pentaen-7-yl)-5-methyl-1,2-oxazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2323402; BDBM50426856
Click to Show/Hide
|
||||
| Activity |
Ki > 332000 nM
|
[8] | |||
| Compound Name |
5-Methyluridine 5'-monophosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
ribo-TMP; 5-methyluridine 5'-phosphate; 5-methyluridine 5'-(dihydrogen phosphate); ribothymidine 5'-phosphate; ribosylthymine 5'-phosphate; 5-methyl-5'-uridylic acid; ribosylthymidine 5'-phosphate; ribosylthymine 5'-monophosphate; ribosylthymidine 5'-monophosphate; 5mUMP; Thymidine-5'- Monophosphate; 5-Methyluridine monophosphate; 5'-Uridylic acid, 5-methyl-; SCHEMBL2883629; CHEMBL1230421; CTK1B6627; DTXSID50510240; DB04243; Q2817106
Click to Show/Hide
|
||||
| Activity |
IC50 = 340000 nM
|
[35] | |||
| Compound Name |
2-Amino-6,7-dimethyl-3,7-dihydropyrimido[4,5-b][1,4]oxazin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3228455; BDBM50000043; AKOS022644611
Click to Show/Hide
|
||||
| Activity |
IC50 = 377000 nM
|
[11] | |||
| Compound Name |
2-Amino-6-methyl-7-phenyl-3,7-dihydropyrimido[4,5-b][1,4]oxazin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3228458; BDBM50000044
Click to Show/Hide
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||||
| Activity |
IC50 = 740000 nM
|
[11] | |||
| Compound Name |
Methyl 2-(2-(3-(5-((2,4-diaminopyrimidin-5-yl)methyl)-2,3-dimethoxyphenyl)acryloyl)-1,2-dihydrophthalazin-1-yl)-2-methylpropanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL565059; BDBM50294208
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| Activity |
IC50 = 813000 nM
|
[36] | |||
| Compound Name |
6,7-Dimethyl-7H-pyrimido[4,5-b][1,4]oxazine-2,4-diamine
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3228466; CTK2H5338; DTXSID20501089; BDBM50000052; 7H-Pyrimido[4,5-b][1,4]oxazine-2,4-diamine, 6,7-dimethyl-
Click to Show/Hide
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| Activity |
IC50 = 903000 nM
|
[11] | |||
| Compound Name |
2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-(ethoxy-hydroxy-phosphoryl)-butyric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL41459; BDBM50005860
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| Activity |
IC50 = 950000 nM
|
[33] | |||
| Compound Name |
2-[[4-[[(2-Amino-4-oxo-5,6,7,8-tetrahydro-3H-pyrido[2,3-d]pyrimidin-6-yl)-methylamino]methyl]benzoyl]amino]pentanedioic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL156308
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||||
| Activity |
IC50 > 1000000 nM
|
[23] | |||
| Compound Name |
2-[[4-[[(2-Amino-4-oxo-5,6,7,8-tetrahydro-3H-pyrido[2,3-d]pyrimidin-6-yl)amino]methyl]benzoyl]amino]pentanedioic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL157230
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| Activity |
IC50 > 1000000 nM
|
[23] | |||
| Compound Name |
3-[3-Benzyl-4-[[[3-benzyl-4-(carboxymethoxy)benzoyl]-(2-methylpropyl)carbamoyl]amino]phenyl]propanoic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3134008; BDBM50496577
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||||
| Activity |
IC50 > 1000000 nM
|
[37] | |||
| Compound Name |
2-Amino-6-(methylsulfonyl)benzothiazole
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
6-(methylsulfonyl)-1,3-benzothiazol-2-amine; 2-Amino-6-methylsulfonylbenzothiazole; 2-Benzothiazolamine, 6-(methylsulfonyl)-; 6-methylsulfonyl-1,3-benzothiazol-2-amine; 6-(Methylsulfonyl)-2-benzothiazolamine; 6-(methylsulfonyl)benzo[d]thiazol-2-amine; 6-methanesulfonyl-1,3-benzothiazol-2-amine; 2-Aminobenzothiazole-6-methyl sulfone; CHEMBL432942; 6-Methanesulfonyl-benzothiazol-2-ylamine; 6-(Methylsulfonyl)benzothiazole-2-ylamine; 2-Amino-6-[methylsulfonyl]benzothiazole; 6-Methylsulphonylbenzothiazol-2-ylamine; EINECS 241-537-2; 2-Aminobenzothiazolyl-6 methyl sulfone; PubChem10344; Maybridge1_008993; MixCom3_000185; 2-amino-6-(methylsulfonyl); Oprea1_366974; KSC495O3N; MLS000084909; BIDD:GT0409; SCHEMBL686784; DTXSID4051796; CTK3J5736; KS-00000FJU; HMS2357K17; ZINC129448; ACT02314; EBD27197; 6-methylsulfonyl-2-aminobenzothiazole; AC-062; ANW-50781; BDBM50335097; CCG-52088; MFCD00179133; SBB042456; STK374502; 2-amino-6-methanesulfonylbenzothiazole; AKOS000119152; 2-Amino-6-(methylsulfonyl)benzothiazol; 6-(methylsulfonyl)benzothiazol-2-amine; 6-Methanesulfonylbenzothiazol-2-ylamine; 6-Methanesulphonyl-2-aminobenzothiazole; CS-W010405; FS-3036; MCULE-3511367981; SDCCGMLS-0054993.P002; VT10063; 2-amino-6-methanesulfonyl-benzothiazole; AK-33732; BR-33732; SC-01809; SMR000019255; DB-027798; AM20030165; FT-0611193; ST45255469; 6-(methylsulfonyl)-1,3-benzothiazol-2-ylamine; S-1840; SR-01000616101-2; W-107846; 6-(Methylsulfonyl)-1,3-benzothiazol-2(3H)-imine #; BRD-K50180361-001-08-0; F0901-0841; Z1245636353
Click to Show/Hide
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| Activity |
IC50 = 1040000 nM
|
[28] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
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| REF 30 | Novel non-active site inhibitor of Cryptosporidium hominis TS-DHFR identified by a virtual screen. Bioorg Med Chem Lett. 2009 Jan 15;19(2):418-23. | ||||
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| REF 32 | Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines. J Med Chem. 1995 Sep 15;38(19):3798-805. | ||||
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| REF 34 | Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methy... J Med Chem. 2005 Nov 17;48(23):7215-22. | ||||
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