Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T20331 | Target Info | |||
| Target Name | Neuropeptide Y receptor type 5 (NPY5R) | ||||
| Synonyms |
Y5 receptor; Neuropeptide Y receptor Y5; Neuropeptide Y (NPY) Y(5) receptor; NPYY5; NPY5R; NPY5-R; NPY-Y5 receptor
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| Target Type | Discontinued Target | ||||
| Gene Name | NPY5R | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Diphenylacetylamino-5-guanidino-pentanoic acid ((S)-2-hydroxy-1-phenyl-ethyl)-amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL41981; BDBM50090276
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| Activity |
IC50 = 68000 nM
|
[1] | |||
| Compound Name |
2-Diphenylacetylamino-5-guanidino-pentanoic acid [1-(4-hydroxy-phenyl)-ethyl]-amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL288355; BDBM50090281
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| Activity |
IC50 = 75000 nM
|
[1] | |||
| Compound Name |
2-Diphenylacetylamino-5-guanidino-pentanoic acid 4-hydroxy-benzylamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL44246; BDBM84996; BDBM50065469; NSC_5311023; L000127; 2-(2,2-Diphenylacetamido)-5-guanidino-N-(4-hydroxybenzyl)pentanamide; 5-carbamimidamido-2-(2,2-diphenylacetamido)-N-[(4-hydroxyphenyl)methyl]pentanamide
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| Activity |
IC50 = 80000 nM
|
[1] | |||
| Compound Name |
N-[4beta-[(2-Naphthylsulfonylamino)methyl]cyclohexane-1alpha-ylmethyl]-2-tetralincarboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL297509; SCHEMBL6039221; BDBM50114990
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| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
2-Diphenylacetylamino-5-guanidino-pentanoic acid ((R)-carbamoyl-phenyl-methyl)-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL42686; BDBM50090272
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| Activity |
IC50 = 163000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-activity relationships of neuropeptide Y Y1 receptor antagonists related to BIBP 3226. Bioorg Med Chem Lett. 2000 Jul 17;10(14):1597-600. | ||||
| REF 2 | High-throughput synthesis optimization of sulfonamide NPY Y5 antagonists. Bioorg Med Chem Lett. 2002 Jul 8;12(13):1771-4. | ||||
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