Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
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| Target ID | T20575 | Target Info | |||
| Target Name | C-C chemokine receptor type 8 (CCR8) | ||||
| Synonyms |
TER1; GPRCY6; GPR-CY6; Chemokine receptor-like 1; Chemokine receptor CCR8; CMKBRL2; CMKBR8; CKRL1; CKR-L1; CDw198; CCR-8; CC-chemokine receptor CHEMR1; CC-CKR-8; CC chemokine receptor CHEMR1; C-C CKR-8
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| Target Type | Clinical trial Target | ||||
| Gene Name | CCR8 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 1 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1,10-Phenanthroline-4,7-diol
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Investigative | Compound Info | ||
| Synonyms |
4,7-Dihydroxy-1,10-phenanthroline; 1,10-Phenanthroline-4,7(1H,10H)-dione; MFCD00004975; CHEMBL1623498; 1,10-dihydro-1,10-phenanthroline-4,7-dione; 1,4,7,10-tetrahydro-1,10-phenanthroline-4,7-dione; pyridino[3,2-h]quinoline-4,7-diol; EINECS 223-493-6; ACMC-1COEH; Oprea1_631021; BIDD:GT0532; 1,1-Phenanthroline-4,7-diol; SCHEMBL1073354; DTXSID0063234; SCHEMBL19318056; CTK1C2783; KS-00000NVS; [1,10]phenanthroline-4,7-diol; 4,7-Dioxylato-1,10-phenanthroline; 5123AB; ANW-29036; BDBM50401357; SBB008750; STK700952; ZINC12341711; AKOS000520806; AKOS015918059; CS-W004566; DS-3423; MCULE-7566362799; NCGC00246264-01; AK106224; SC-08302; DB-050452; ST4066281; D3869; FT-0707691; 4,7-Dihydroxy-1,10-phenanthroline, Dye content >=30 %; 1,10-phenanthroline-4,7-diol4,7-dihydroxy-1,10-phenanthroline
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| Activity |
EC50 = 79432.82 nM
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[1] | |||
| Non Binders of This Target (in total, 5 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2,6-Bis(2-pyridyl)-4(1H)-pyridone
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Investigative | Compound Info | ||
| Synonyms |
[2,2':6',2''-Terpyridin]-4'-ol; [2,2':6',2''-Terpyridin]-4'(1'H)-one; 2,6-dipyridin-2-yl-1H-pyridin-4-one; 2,2':6',2''-Terpyridin-4'-ol; CHEMBL2205804; MFCD01321386; [2,2,6,2-terpyridin]-4(1H)-one; 4'-HYDROXY-2,2':6',2''-TERPYRIDINE; 4-Terpyridone; ACMC-209bep; 1'H-[2,2',6',2'']Terpyridin-4'-one; ACMC-20m41v; SCHEMBL1988750; CTK0H0167; CTK0H4325; KS-00000USR; ZINC403259; KS-00001KN4; 2,6-bis-pyridyl-4-(1H)-pyridone; ANW-19055; BDBM50401356; MFCD06796976; 2,6-bis(2-pyridyl)-4(1H)pyridone; 2,6-Bis(pyridin-2-yl)pyridin-4-ol; AKOS015912996; AKOS015914629; 2,6-Di(2-pyridyl)-4(1H)-pyridone; 2,6-bis(pyridin-2-yl)-4(1h)-pyridone; AC-27853; AS-62574; SC-70393; SY052797; 2,6-di(pyridin-2-yl)pyridin-4(1h)-one; Z2460; 1'H-[2,2';6',2'']terpyridin-4'-on; 1'H-[2,2';6',2'']terpyridin-4'-one; 1'H-[2,2';6',2'']terpyridine-4'-one; 2,6-?Bis(2-?pyridyl)?-?4(1H)-pyridone; 2,6-Bis(pyridine-2-yl)pyridine-4(1H)-one; 6-(pyridin-2-yl)-[2,2'-bipyridine]-4-ol; 1'H-[2,2';6',2 '']terpyridine-4'-one; 2,6-Bis(2-pyridyl)-4(1H)-pyridone, 98%; J-005568; J-400598; 6-(pyridin-2-yl)-1,4-dihydro-[2,2'-bipyridin]-4-one
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| Activity |
EC50 > 1000000 nM
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[1] | |||
| Compound Name |
Neocuproine
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Investigative | Compound Info | ||
| Synonyms |
2,9-Dimethyl-1,10-phenanthroline; 1,10-Phenanthroline, 2,9-dimethyl-; Neocuproin; 2,9-Dimethylphenanthroline; 2,9-Dimethyl-o-phenanthroline; neo-Cuproin; DMPHEN; Neocuproine hemihydrate; NSC4280; UNII-8E7D2SH3BV; 8E7D2SH3BV; MLS001194484; GNF-PF-5611; MFCD00004973; SMR000555011; DMPHEN; NSC 4280; Neocuproin; VUF 7738; 2,9-dimethylpyridino[3,2-h]quinoline; MFCD00149306; NSC 4280; EINECS 207-601-9; 2,9-Dimethyl-1,10-phenanthroline hemihydrate, 98%; 2,10-phenanthroline; Neocuproine, >=98%; 1, 2,9-dimethyl-; NCIMech_000034; Oprea1_068014; cid_65237; KSC496I5N; 484-11-7 (anhydrous); SCHEMBL124563; CHEMBL375781; DTXSID5060065; BDBM64740; CTK3J6456; HMS2230M06; HMS3373K19; KUC107774N; ZINC119332; 2,10-dimethyl-1,9-phenanthroline; BCP18357; DNDI1343110; KS-00000VG9; KSC-09-264B; NSC-4280; 2,9-di-methyl-1,10-phenanthroline; 3,6-Dimethyl-4,5-diazaphenanthrene; ANW-41947; CCG-16034; CCG-35468; SBB008718; AKOS000511700; CS-W004563; MCULE-3651567163; NCGC00245843-01; AK134888; AS-14894; NCI60_003986; SC-18587; ST013881; SY010909; DB-050426; D0771; EU-0036872; FT-0610770; Neocuproine, Vetec(TM) reagent grade, 98%; A-8054; 2,9-Dimethyl-1,10-phenanthroline Neocuproine; AB00443806-10; AB00443806-12; A827529; Q409347; J-610070; BRD-K16598630-001-05-7; Z2301294930; 2,9-DIMETHYL-1,10-PHENANTHROLINE, REAGENT (ACS)
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| Activity |
EC50 > 1000000 nM
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[1] | |||
| Compound Name |
1,10-Phenanthroline-2,9-dicarbaldehyde
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Investigative | Compound Info | ||
| Synonyms |
1,10-Phenanthroline-2,9-dicarboxaldehyde; 2,9-diformyl-1,10-phenanthroline; [1,10]Phenanthroline-2,9-dicarbaldehyde; CHEMBL2205803; Cambridge id 5478062; SCHEMBL1088335; ZINC218307; ALBB-027841; BDBM50401341; MFCD00774291; SBB098585; AKOS001703860; MCULE-6152111599; BS-17263; CS-0030363; pyridino[3,2-h]quinoline-2,9-dicarbaldehyde; AB00086514-01; J-400084; Q30948420
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| Activity |
EC50 > 1000000 nM
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[1] | |||
| Compound Name |
2,9-Bis(bromomethyl)-1,10-phenanthroline
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Investigative | Compound Info | ||
| Synonyms |
NSC602850; CHEMBL1976682; SCHEMBL1258482; CTK2G4820; DTXSID70326587; ZINC1608162; BDBM50401340; NSC-602850; NCI60_004569; 1,10-Phenanthroline, 2,9-bis(bromomethyl)-
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| Activity |
EC50 > 1000000 nM
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[1] | |||
| Compound Name |
1,10-Phenanthroline-2,9-diyldimethanol
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Investigative | Compound Info | ||
| Synonyms |
(1,10-Phenanthroline-2,9-diyl)dimethanol; [9-(hydroxymethyl)-1,10-phenanthrolin-2-yl]methanol; NSC353096; UNII-1BR6ZZ33GT; 1BR6ZZ33GT; 2,9-Bis(hydroxymethyl)-1,10-phenanthroline; CHEMBL2205802; NSC 353096; SCHEMBL5301328; CTK5E6149; DTXSID90229329; ZINC391500; BDBM50401342; 1,10-Phenanthroline-2,9-dimethanol; NSC-353096; 2.9-Bis(hydroxymethyl)-1,10-phenanthroline; (9-Hydroxymethyl-[1,10]phenanthrolin-2-yl)-methanol
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| Activity |
EC50 > 1000000 nM
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[1] | |||
| References | Top | ||||
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| REF 1 | Modulation in selectivity and allosteric properties of small-molecule ligands for CC-chemokine receptors. J Med Chem. 2012 Sep 27;55(18):8164-77. | ||||
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