Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T22655 | Target Info | |||
| Target Name | Mucosal addressin cell adhesion molecule 1 (MADCAM1) | ||||
| Synonyms |
hMAdCAM-1; MAdCAM-1; MADCAM1
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| Target Type | Clinical trial Target | ||||
| Gene Name | MADCAM1 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 1 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(S)-3-((S)-2-Acetylamino-4-methyl-pentanoylamino)-N-((S)-1-carbamoyl-2-methyl-propyl)-succinamic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL162906; BDBM50291325
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| Activity |
IC50 = 126000 nM
|
[1] | |||
| Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-((S)-2-Acetylamino-4-methyl-pentanoylamino)-3-((S)-1-carbamoyl-2-methyl-propylsulfamoyl)-butyric acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL163157; BDBM50291324
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| Activity |
IC50 = 219000 nM
|
[1] | |||
| Compound Name |
(S)-3-((S)-2-Acetylamino-4-methyl-pentanoylamino)-N-((1S,2R)-1-carbamoyl-2-hydroxy-propyl)-succinamic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL289974; BDBM50070605
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| Activity |
IC50 = 276000 nM
|
[1] | |||
| Compound Name |
(S)-3-((S)-2-Acetylamino-4-methyl-pentanoylamino)-N-{(1S,2R)-1-[(S)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-2-hydroxy-ethylcarbamoyl]-2-hydroxy-propyl}-succinamic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL310968; BDBM50291323
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| Activity |
IC50 = 298000 nM
|
[1] | |||
| Compound Name |
4-[[(2S)-2-Acetamido-4-methylpentanoyl]amino]-3-[[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]sulfamoyl]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL164265; BDBM50291322
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| Activity |
IC50 > 500000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Sulfonopeptide inhibitors of leukocyte adhesion. Bioorg Med Chem Lett. 1997 Mar 18;7(6):711-4. | ||||
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