Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T23714 | Target Info | |||
| Target Name | B2 bradykinin receptor (BDKRB2) | ||||
| Synonyms |
Bradykinin B2 receptor; BKR2; BK-2 receptor; BK B(2) receptor; B2R
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| Target Type | Successful Target | ||||
| Gene Name | BDKRB2 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 9 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-(Naphthalen-2-ylsulfonylamino)-3-phenyl-N-[[4-(piperidin-1-ylmethyl)phenyl]methyl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL221691; BDBM50203207; 3-(RS)-N-(4-(piperidin-1-ylmethyl)benzyl)-3-(naphthalene-7-sulfonamido)-3-phenylpropanamide
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| Activity |
Ki = 56000 nM
|
[1] | |||
| Compound Name |
(R)-3-(Naphthalene-7-sulfonamido)-3-phenyl-N-((R)-6-(piperidin-1-ylmethyl)-1,2,3,4-tetrahydronaphthalen-1-yl)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL218152; SCHEMBL4141031; BDBM50203205
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| Activity |
Ki = 57000 nM
|
[1] | |||
| Compound Name |
[4-[[2-[Bis(propan-2-ylamino)methylideneamino]acetyl]amino]phenyl]methyl-tributylphosphanium;chloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL558233
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| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
[4-[[2-[Bis(propan-2-ylamino)methylideneamino]acetyl]amino]phenyl]methyl-tributylphosphanium;dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1162588
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| Activity |
Ki ~ 100000 nM
|
[3] | |||
| Compound Name |
1-(3-Amino-benzyl)-3-benzyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL143931; BDBM50075191
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| Activity |
Ki ~ 100000 nM
|
[4] | |||
| Compound Name |
Tributyl-[[4-[[(2S)-2-[(N,N'-dicyclohexylcarbamimidoyl)amino]-4-methylpentanoyl]amino]phenyl]methyl]phosphanium;chloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL540897
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| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
3-Benzyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL342117; SCHEMBL9527413; BDBM50075188
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| Activity |
Ki ~ 100000 nM
|
[4] | |||
| Compound Name |
Tributyl-[[4-[[(2S)-2-[(N,N'-dicyclohexylcarbamimidoyl)amino]-4-methylpentanoyl]amino]phenyl]methyl]phosphanium;dihydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1162587
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| Activity |
Ki ~ 100000 nM
|
[3] | |||
| Compound Name |
(3-Benzyl-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl)-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL142527; BDBM50075186
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| Activity |
Ki ~ 100000 nM
|
[4] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of a nonpeptidic and conformationally restricted bradykinin B1 receptor antagonist with anti-inflammatory activity. J Med Chem. 2007 Feb 22;50(4):607-10. | ||||
| REF 2 | Structure activity relationships of non-peptide bradykinin B2 receptor antagonists. Bioorg Med Chem Lett. 1995 Feb 16;5(4):357-62. | ||||
| REF 3 | Design of potent non-peptide competitive antagonists of the human bradykinin B2 receptor. J Med Chem. 1993 Aug 20;36(17):2583-4. | ||||
| REF 4 | The design of non-peptide human bradykinin B2 receptor antagonists employing the benzodiazepine peptidomimetic scaffold. Bioorg Med Chem Lett. 1999 Feb 8;9(3):463-8. | ||||
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