Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T24793 | Target Info | |||
| Target Name | Voltage-gated calcium channel alpha Cav1.3 (CACNA1D) | ||||
| Synonyms |
Voltage-gated calcium channel alpha subunit Cav1.3; Voltage-gated L-type Ca2+ channel alpha1D; Calcium channel, L type, alpha-1 polypeptide, isoform 2; CACNA1D
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| Target Type | Clinical trial Target | ||||
| Gene Name | CACNA1D | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 8 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Ethyl 6-(furan-2-yl)-2-methyl-4-(4-methylphenyl)-1,4-dihydropyridine-3-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3261115; BDBM50014328
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| Activity |
IC50 = 55500 nM
|
[1] | |||
| Compound Name |
S-Tert-butyl 2-methyl-4-(4-methylphenyl)-6-phenyl-1,4-dihydropyridine-3-carbothioate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3221244; BDBM50014257
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| Activity |
IC50 = 56200 nM
|
[1] | |||
| Compound Name |
Ethyl 6-(4-chlorophenyl)-2-methyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3260896; BDBM50014321
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| Activity |
IC50 = 57100 nM
|
[1] | |||
| Compound Name |
S-Tert-butyl 4-(4-bromophenyl)-2-methyl-6-(4-methylphenyl)-1,4-dihydropyridine-3-carbothioate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3221243; BDBM50014248
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| Activity |
IC50 = 59600 nM
|
[1] | |||
| Compound Name |
S-Tert-butyl 2-methyl-6-phenyl-4-[(E)-1-phenylprop-1-en-2-yl]-1,4-dihydropyridine-3-carbothioate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3221247; BDBM50014333
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| Activity |
IC50 = 63100 nM
|
[1] | |||
| Compound Name |
S-Tert-butyl 2-methyl-4,6-diphenyl-1,4-dihydropyridine-3-carbothioate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3221241; BDBM50014175
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| Activity |
IC50 = 95800 nM
|
[1] | |||
| Compound Name |
CID 71463101
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Investigative | Compound Info | ||
| Synonyms |
GV-58; CHEMBL2206242; SCHEMBL17628602; GV58;GV 58; BCP23927; BDBM50400564; ZINC95559479; CS-3617; NCGC00390421-03; GV-58, >=97% (HPLC); HY-12498
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
S-Tert-butyl 2-methyl-4,6-bis(4-methylphenyl)-1,4-dihydropyridine-3-carbothioate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3221245; BDBM50014272
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | New 5-unsubstituted dihydropyridines with improved CaV1.3 selectivity as potential neuroprotective agents against ischemic injury. J Med Chem. 2014 May 22;57(10):4313-23. | ||||
| REF 2 | Synthesis and biological evaluation of a selective N- and p/q-type calcium channel agonist. ACS Med Chem Lett. 2012 Oct 1;3(12):985-90. | ||||
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