Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
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| Target ID | T25464 | Target Info | |||
| Target Name | Calcineurin (PPP3CA) | ||||
| Synonyms |
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; Calmodulin-dependent calcineurin A subunit alpha isoform; CNA; CAM-PRP catalytic subunit; CALNA
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| Target Type | Successful Target | ||||
| Gene Name | PPP3CA | ||||
| Biochemical Class | Phosphoric monoester hydrolase | ||||
| UniProt ID | |||||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-{4-[2-(S)-Allyloxycarbonylamino-3-{4-[(2-carboxy-phenyl)-oxalyl-amino]-phenyl}-propionylamino]-butoxy}-6-hydroxy-benzoic acid methyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL325029; OIC ACID METHYL ESTER; SCHEMBL6500588; BDBM50131545; DB04088; Q27454316
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| Activity |
Ki > 200000 nM
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[1] | |||
| Compound Name |
Oxalylarylaminobenzoic Acid Analog 12a
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL303333; BDBM13953; linked-fragment derived compound 12; 2-({4-[2-acetamido-2-(pentylcarbamoyl)ethyl]naphthalen-1-yl}amidoformic acid)benzoic acid; 2-{[4-(2-Acetylamino-2-pentylcarbamoylethyl)naphthalen-1-yl]oxalylamino}benzoic Acid; n-acetyl-4-[(carboxycarbonyl)(2-carboxyphenyl)amino]-n-pentyl-1-naphthylalaninamide
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| Activity |
Ki > 300000 nM
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[2] | |||
| References | Top | ||||
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| REF 1 | Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands. J Med Chem. 2003 Jul 31;46(16):3437-40. | ||||
| REF 2 | Discovery and structure-activity relationship of oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B. J Med Chem. 2003 May 22;46(11):2093-103. | ||||
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