Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T26846 | Target Info | |||
| Target Name | Phospholipase C-beta-1 (PLCB1) | ||||
| Synonyms |
Phospholipase C-beta1; Phospholipase C-I; Phosphoinositide phospholipase C-beta-1; Phosphoinositide phospholipase C; PLC-beta-1; PLC-I; PLC-154; KIAA0581; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Click to Show/Hide
|
||||
| Target Type | Literature-reported Target | ||||
| Gene Name | PLCB1 | ||||
| Biochemical Class | Phosphoric diester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(1S,3R)-ACPD
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(1S,3R)-1-ACPD; trans-ACPD; (1S,3S)-ACPD; 1S,3R-ACPD
Click to Show/Hide
|
||||
| Activity |
EC50 = 50000 nM
|
[1] | |||
| Compound Name |
(S)-3,5-Dihydroxyphenylglycine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(S)-3,5-DHPG; S-DHPG; L-3,5-Dihydroxyphenylglycine; C8H9NO4; UNII-CF5G2G268A; CHEMBL39221; 3,5-Dihydroxy-L-phenylglycine; CF5G2G268A; (S)-3,5 DHPG; (S)-3,5-Dihydroxyphenylglycine hydrate; Benzeneacetic acid, alpha-amino-3,5-dihydroxy-, (alphaS)-; (2r)-Amino(3,5-Dihydroxyphenyl)Acetic Acid; (2S)-amino(3,5-dihydroxyphenyl)ethanoic acid; (S)-2-amino-2-(3,5-dihydroxyphenyl)acetic acid; (S)-3,5-dihydroxyphenylglycine zwitterion; Tocris-0342; Tocris-0805; Lopac-D-3689; C12026; 3,5-Dihydroxy-phenylglycine; Lopac0_000328; (2S)-2-amino-2-(3,5-dihydroxyphenyl)acetic acid; SCHEMBL12648471; (s)-3,5-dihydroxylphenylglycine; CTK8F0556; DTXSID20904031; HMS3261A17; HMS3266F22; HMS3411L21; HMS3675L21; ZINC968043; Dihydroxyphenylglycine, (S)-3,5-; Tox21_500328; BDBM50079183; MFCD11044457; AKOS006239507; amino(3,5-dihydroxyphenyl)acetic acid; CCG-204423; DB04228; LP00328; SDCCGSBI-0050316.P002; NCGC00015338-01; NCGC00015338-02; NCGC00024545-01; NCGC00024800-01; NCGC00024800-02; NCGC00024800-03; NCGC00024800-04; NCGC00024800-05; NCGC00024800-10; NCGC00261013-01; HY-12598; Amino-(3,5-dihydroxy-phenyl)-acetic acid; J516.528H; (2S)-amino(3,5-dihydroxyphenyl)acetic acid; B6459; CS-0012064; EU-0100328; (S)-Amino-(3,5-dihydroxy-phenyl)-acetic acid; D 3689; SR-01000075813; SR-01000597444; Amino-(3,5-dihydroxy-phenyl)-acetic acid(S-DHPG); J-009981; SR-01000075813-1; SR-01000597444-1; Q27095051; UNII-5YR2N37E6D component HOOWCUZPEFNHDT-ZETCQYMHSA-N
Click to Show/Hide
|
||||
| Activity |
EC50 = 65000 nM
|
[1] | |||
| Compound Name |
alpha-Methyl-4-carboxyphenylglycine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(RS)-MCPG; alpha-Mcpg; 4-(1-amino-1-carboxyethyl)benzoic acid; (+/-)-alpha-Methyl-4-carboxyphenylglycine; (R,S)-MCPG; Benzeneacetic acid, alpha-amino-4-carboxy-alpha-methyl-; CHEMBL299683; (+/-)-alpha-Methyl-(4-carboxyphenyl)glycine; (rs)-alpha-methyl-4-carboxyphenylglycine; Benzeneacetic acid, a-amino-4-carboxy-a-methyl-; (+/-)-MCPG; alpha-Amino-4-carboxy-alpha-methylbenzeneacetic acid; ACMC-20cchr; 4-(1-AMINO-1-CARBOXY-ETHYL)-BENZOIC ACID; Lopac0_000747; SCHEMBL715285; (+-)-MCPG; (+/-)MCPG; CTK4C5052; KS-00001CLO; DTXSID80861398; HMS3262E16; BCP18268; Benzeneacetic acid, alpha-amino-4-carboxy-alpha-methyl-, (+-)-; Tox21_500747; BDBM50030627; MFCD00210205; (RS)-?-Methyl-4-carboxyphenylglycine; AKOS005066801; CCG-204832; CS-5708; LP00747; SDCCGSBI-0050725.P002; (y)-alpha-Methyl-4-carboxyphenylglycine; (?)-alpha-Methyl-4-carboxyphenylglycine; alpha-Methyl-2-(4-carboxyphenyl)glycine; NCGC00015676-03; NCGC00015676-04; NCGC00015676-05; NCGC00015676-06; NCGC00015676-09; NCGC00024542-02; NCGC00024542-03; NCGC00024542-04; NCGC00261432-01; BS-15439; (r,s)-alpha-methyl-4-carboxyphenylglycine; HY-100371; EU-0100747; ST50825577; Benzeneacetic acid,a-amino-4-carboxy-a-methyl-; M 4796; L000020; SR-01000075733; J-008240; SR-01000075733-1; 4-(1-Amino-1-carboxy-ethyl)-benzoic acid(S-M4CPG); Q27268302
Click to Show/Hide
|
||||
| Activity |
IC50 = 150000 nM
|
[1] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(1R,2S,3S)-2-(Amino-carboxy-methyl)-3-phenyl-cyclopropanecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL72157; BDBM50050924
Click to Show/Hide
|
||||
| Activity |
EC50 > 300000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | (2R,1'S,2'R,3'S)-2-(2'-Carboxy-3'-phenylcyclopropyl)glycine (PCCG-13), the first potent and selective competitive antagonist of phospholipase D-coupled metabotropic glutamate receptors: asymmetric synthesis and preliminary biological properties. J Med Chem. 1999 Jul 15;42(14):2716-20. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.