Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T26851 | Target Info | |||
| Target Name | Complement C3 (CO3) | ||||
| Synonyms |
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3
Click to Show/Hide
|
||||
| Target Type | Successful Target | ||||
| Gene Name | C3 | ||||
| Biochemical Class | Complement system | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
I[Cvvqdwghhrc]T-NH2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL265136; BDBM50159056
Click to Show/Hide
|
||||
| Activity |
IC50 = 53600 nM
|
[1] | |||
| Compound Name |
Compstatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL266963; ICVVQDWGHHRCT-NH2; GTPL9218; BDBM50241352; s8522; AKOS024457182; CCG-270690; Q27076880
Click to Show/Hide
|
||||
| Activity |
IC50 = 63000 nM
|
[2] | |||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Ac-I[CVVdQDWGHHRC]-NH2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL413870; BDBM50159070
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
2-[(4R,7S,10R,13S,19R,22R,25S,28R,31S,34R)-34-[[(2S,3S)-2-Acetamido-3-methylpentanoyl]amino]-25-(3-amino-3-oxopropyl)-4-carbamoyl-7-[3-(diaminomethylideneamino)propyl]-10,13-bis(1H-imidazol-5-ylmethyl)-19-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33-decaoxo-28,31-di(propan-2-yl)-1,2-dithia-5,8,11,14,17,20,23,26,29,32-decazacyclopentatriacont-22-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL263238; BDBM50159053
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. J Med Chem. 2005 Jan 13;48(1):274-86. | ||||
| REF 2 | Chemical Approaches to Modulating Complement-Mediated Diseases. J Med Chem. 2018 Apr 26;61(8):3253-3276. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.