Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T31204 | Target Info | |||
| Target Name | 5-HT 2B receptor (HTR2B) | ||||
| Synonyms |
Serotonin receptor 2B; 5-hydroxytryptamine receptor 2B; 5-HT2B; 5-HT-2B; 5-HT 2B
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| Target Type | Successful Target | ||||
| Gene Name | HTR2B | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
6-Chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)quinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL468176; BDBM50261729
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-(2,6-Difluorophenyl)-N-[5-[1-hydroxy-1-(4-methyl-1,3-thiazol-2-yl)ethyl]-1,3,4-thiadiazol-2-yl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3088176; BDBM50443001
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| Activity |
IC50 = 64000 nM
|
[2] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-[2-Hydroxy-3-methyl-4-[[4-[4-(2H-tetrazol-5-yl)pyridin-2-yl]oxyphenyl]methoxy]phenyl]ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3899832; SCHEMBL3163790; BDBM50207400
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| Activity |
Ki > 3300000 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural modifications of N-arylamide oxadiazoles: Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4267-74. | ||||
| REF 2 | Methyl-thiazoles: a novel mode of inhibition with the potential to develop novel inhibitors targeting InhA in Mycobacterium tuberculosis. J Med Chem. 2013 Nov 14;56(21):8533-42. | ||||
| REF 3 | Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache. Bioorg Med Chem Lett. 2017 Jan 15;27(2):323-328. | ||||
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