Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T31946 | Target Info | |||
| Target Name | Vascular endothelial growth factor receptor (VEGFR) | ||||
| Target Type | Successful Target | ||||
| Gene Name | NO-GeName | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Methyl-5-(5-methyl-pyrrolo[2,1-f][1,2,4]triazin-4-ylamino)-phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL188522; SCHEMBL4044449; BDBM50150769; 2-methyl-5-[(5-methylpyrrolo[2,1-f][1,2,4]triazin-4-yl)amino]phenol
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|
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| Activity |
IC50 = 98000 nM
|
[1] | |||
| Compound Name |
2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-propenyl)-1,6-dimethyl-1,8-dihydro-imidazo[4,5-h]isoquinolin-9-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL281957; SCHEMBL6621670; BDBM50126732
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Non Binders of This Target (in total, 8 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Methyl-5-(6-methyl-pyrrolo[2,1-f][1,2,4]triazin-4-ylamino)-phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184750; SCHEMBL4046712; BDBM50150768; 2-methyl-5-[(6-methylpyrrolo[2,1-f][1,2,4]triazin-4-yl)amino]phenol; 4-(3-Hydroxy-4-methyl-phenylamino)-6-methyl-pyrrolo[2,1-f][1,2,4]triazine
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|
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| Activity |
IC50 = 213000 nM
|
[1] | |||
| Compound Name |
5-(5,6-Dimethyl-pyrrolo[2,1-f][1,2,4]triazin-4-ylamino)-2-methyl-phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL186001; SCHEMBL4045525; BDBM50150771; 5-[(5,6-dimethylpyrrolo[2,1-f][1,2,4]triazin-4-yl)amino]-2-methylphenol
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|
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| Activity |
IC50 = 310000 nM
|
[1] | |||
| Compound Name |
2-Methyl-5-(pyrrolo[2,1-f][1,2,4]triazin-4-ylamino)-phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185853; SCHEMBL1461105; BDBM50150770; 2-methyl-5-(pyrrolo[2,1-f][1,2,4]triazin-4-ylamino)phenol
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|
||||
| Activity |
IC50 = 360000 nM
|
[1] | |||
| Compound Name |
2-Methyl-5-(7-methyl-pyrrolo[2,1-f][1,2,4]triazin-4-ylamino)-phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL187431; SCHEMBL4050828; BDBM50150774; 2-methyl-5-[(7-methylpyrrolo[2,1-f][1,2,4]triazin-4-yl)amino]phenol; 4-(3-Hydroxy-4-methyl-phenylamino)-7-methyl-pyrrolo[2,1-f][1,2,4]triazine
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|
||||
| Activity |
IC50 = 477000 nM
|
[1] | |||
| Compound Name |
(3-Chloro-4-fluoro-phenyl)-(7-methyl-pyrrolo[2,1-f][1,2,4]triazin-4-yl)-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184311; BDBM50150775
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|
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| Activity |
IC50 > 2500000 nM
|
[1] | |||
| Compound Name |
(3-Chloro-4-fluoro-phenyl)-(5-methyl-pyrrolo[2,1-f][1,2,4]triazin-4-yl)-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL188304; BDBM50150776; ZINC13581398; N-(3-chloro-4-fluorophenyl)-5-methylpyrrolo[1,2-f][1,2,4]triazin-4-amine
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|
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| Activity |
IC50 > 2500000 nM
|
[1] | |||
| Compound Name |
(3-Chloro-4-fluoro-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-4-yl-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185637; BDBM50150772; N-(3-chloro-4-fluorophenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine
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|
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| Activity |
IC50 > 2500000 nM
|
[1] | |||
| Compound Name |
(3-Chloro-4-fluoro-phenyl)-(6-methyl-pyrrolo[2,1-f][1,2,4]triazin-4-yl)-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL186080; BDBM50150773
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|
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| Activity |
IC50 > 2500000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of the pyrrolo[2,1-f][1,2,4]triazine nucleus as a new kinase inhibitor template. J Med Chem. 2004 Jul 29;47(16):4054-9. | ||||
| REF 2 | Optimization of 2-phenylaminoimidazo[4,5-h]isoquinolin-9-ones: orally active inhibitors of lck kinase. J Med Chem. 2003 Apr 10;46(8):1337-49. | ||||
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