Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T33367 | Target Info | |||
| Target Name | Cytoplasmic aspartate aminotransferase (GOT1) | ||||
| Synonyms |
Glutamate oxaloacetate transaminase-1; GOT1
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|
||||
| Target Type | Literature-reported Target | ||||
| Gene Name | GOT1 | ||||
| Biochemical Class | Transaminase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 74 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4249221
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462468
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|
||||
| Activity |
IC50 = 52000 nM
|
[1] | |||
| Compound Name |
Chembl4243428
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462469
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|
||||
| Activity |
IC50 = 56000 nM
|
[1] | |||
| Compound Name |
Chembl4239412
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462481
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|
||||
| Activity |
IC50 = 62000 nM
|
[1] | |||
| Compound Name |
Chembl4244956
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462503; AKOS007000521; AB00045823-01
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|
||||
| Activity |
IC50 = 63000 nM
|
[1] | |||
| Compound Name |
Chembl4237469
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462485
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|
||||
| Activity |
IC50 = 64000 nM
|
[1] | |||
| Compound Name |
1-(4-Bromophenyl)-3-[2-(1H-indol-3-yl)ethyl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4237444; ZINC5555795; BDBM50462480; STL241916; AKOS007001169; MCULE-3786014757
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|
||||
| Activity |
IC50 = 67000 nM
|
[1] | |||
| Compound Name |
Chembl4242135
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462525
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|
||||
| Activity |
IC50 = 76000 nM
|
[1] | |||
| Compound Name |
4-(1H-Indol-4-yl)-N-phenylpiperazine-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
iGOT1-01; CHEMBL4237925; Oprea1_534811; 1-piperazinecarboxamide,4-(1h-indol-4-yl)-n-phenyl-; ZINC162888; EX-A4397; BDBM50462552
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|
||||
| Activity |
IC50 = 85000 nM
|
[1] | |||
| Compound Name |
Chembl4238525
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL14590550; (4-acetylpiperazinyl)-N-benzamide; BDBM50462542; ZINC13576396; AKOS004043260; MCULE-9171545517; ST51041139
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-Methyl-N-phenylpiperazine-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1622367; CBMicro_015078; Cambridge id 5250824; Oprea1_062217; Oprea1_543013; SCHEMBL4300084; CTK6I2908; (4-methylpiperazinyl)-N-benzamide; ZINC236021; BDBM50462540; STK325711; AKOS000384279; MCULE-3669682522; 4-methyl-N-phenyl-1-piperazinecarboxamide; BIM-0015340.P001; 1-methyl-4-(N-phenylamino)carbonylpiperazine; ST50277628; AB00076728-01; 4-[(4-METHYL-PIPERAZINE-1-CARBONYL)-AMINO]-BENZENE
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4237836
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462470; ZINC19141856; AKOS024358840; MCULE-5726591783; ST50988144; N-phenyl(4-(4-pyridyl)piperazinyl)carboxamide
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-(4-Methoxyphenyl)-N-phenylpiperazine-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4239559; Cambridge id 6778429; Oprea1_466503; Oprea1_792929; ZINC355745; BDBM50462539; STL282943; AKOS000384286; MCULE-1985047987; ST066611; [4-(4-methoxyphenyl)piperazinyl]-N-benzamide
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-Ethyl-N-phenylpiperazine-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4243606; Oprea1_104762; Oprea1_609093; SCHEMBL14595398; ZINC386731; BDBM50462550; STL254922; AKOS000380859; MCULE-3535183250
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4243944
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462543
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4237924
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462472
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-(Methylsulfonyl)-N-phenyl-1-piperazinecarboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1725082; MLS000663285; HMS2649F18; ZINC8169493; BDBM50462541; STK483108; AKOS003323719; MCULE-7880449956; SMR000301316; [4-(methylsulfonyl)piperazinyl]-N-benzamide; ST50835973; 4-(methylsulfonyl)-N-phenylpiperazine-1-carboxamide
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-Pyridin-4-yl-piperazine-1-carboxylic acid (4-chloro-phenyl)-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL367728; BDBM50163238
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4240435
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462538
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4238484
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462491
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4238024
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462519
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4244238
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462521
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4248258
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462551
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4244692
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20328219; BDBM50462476
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4237818
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462512
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4244942
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462514
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4245629
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462494
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N,4-Diphenylpiperazine-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
MLS002694823; CHEMBL1899594; N-PHENYL(4-PHENYLPIPERAZINYL)FORMAMIDE; NSC88247; CBMicro_026731; Cambridge id 5628622; NCIOpen2_005159; Oprea1_400520; Oprea1_694442; SCHEMBL13911678; CTK1D8100; DTXSID60293279; HMS1779K21; HMS3085C22; KS-000029GV; BDBM50462489; HTS028176; MFCD01358911; N,4-diphenyl-1-piperazinecarboxamide; NSC-88247; STK416256; ZINC11524117; AKOS001153127; MCULE-1479416575; MS-8255; N-phenyl(4-phenylpiperazinyl)carboxamide; SMR001560742; BIM-0026618.P001; ST50031709; AB00018371-01; AB00018371-02; BRD-K85758810-001-04-8
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[4-(Benzyloxycarbonyl)piperazino]-1H-indole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4239480; SCHEMBL2354773; BDBM50462479; ZINC118707188; benzyl 4-(1H-indol-4-yl)piperazine-1-carboxylate
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4241212
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|
Investigative | Compound Info | ||
| Synonyms |
Oprea1_116872; ZINC135911; BDBM50462534; MCULE-8106266120
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-[2-(1H-Indol-3-yl)ethyl]-3-phenylurea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1413182; 3-[2-(1H-indol-3-yl)ethyl]-1-phenylurea; ChemDiv3_011925; 1-[2-(1H-Indol-3-yl)-ethyl]-3-phenyl-urea; Oprea1_009981; Oprea1_822912; MLS000067867; SCHEMBL734585; HMS1506O01; HMS2370D03; HMS3447I20; ZINC139516; KS-00003PX8; BDBM50462506; STL521132; AKOS000545101; CCG-142867; MCULE-9187480094; MS-8818; IDI1_029483; NCGC00280029-01; SMR000122486; ST000490; EU-0016351; 1-Phenyl-3-[2-(1H-indole-3-yl)ethyl]urea; N-[2-(1H-indol-3-yl)ethyl]-N'-phenylurea; 1-(2-(1H-Indol-3-yl)ethyl)-3-phenyl-urea; N-(2-indol-3-ylethyl)(phenylamino)carboxamide; AB00461199-08; BRD-K91166726-001-01-5; BRD-K91166726-001-08-0
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4246391
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462488
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4244798
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462537
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4245951
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462527
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4239635
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462497
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4237667
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462548
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4250000
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462547
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4247475
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462516
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4250509
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462499
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4250894
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462509
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4245617
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462482
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4242299
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462484
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4242639
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462510
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4240748
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462465
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4247855
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462544
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4248831
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462536
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4250202
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462526
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4241990
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462471
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4241649
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462531
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4245514
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462495
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4241306
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462522
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4247937
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462532
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4239952
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462478
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4238089
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462545
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4248740
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462515
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4237682
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462500
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4241826
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462507
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4246679
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462549
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4238388
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462467
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4241402
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462508
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4238911
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462490
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4242890
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462474
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4248956
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462511
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4248489
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462520
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4251316
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462493
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4249657
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC87929; Cambridge id 5269386; Oprea1_150080; Oprea1_545193; CBDivE_015445; ZINC207061; BDBM50462475; NSC-87929; AKOS000521078; MCULE-1816266493; ST50982271; [4-(2-methoxyphenyl)piperazinyl]-N-benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4244473
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462492
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4237490
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462487
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4241969
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462513
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4238138
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462501
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4241190
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462517
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4242398
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462498
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4237401
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
ZINC462819; BDBM50462483; AKOS000545391
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4242559
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462518
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4248152
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462463
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma. Bioorg Med Chem Lett. 2018 Sep 1;28(16):2675-2678. | ||||
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