Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T33901 | Target Info | |||
| Target Name | Niemann-Pick C1-like protein 1 (NPC1L1) | ||||
| Synonyms |
Niemann-Pick C1 Like 1; NPC1L1
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| Target Type | Successful Target | ||||
| Gene Name | NPC1L1 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 6 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-Fluoro-N-[(2R,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3402514; SCHEMBL18279403; BDBM50069551
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| Activity |
IC50 = 54000 nM
|
[1] | |||
| Compound Name |
Tert-butyl(2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)acetamido)methylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1629896; BDBM50332408
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| Activity |
IC50 = 59000 nM
|
[2] | |||
| Compound Name |
N-[(2R,3R)-1-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3402513; SCHEMBL16830661; BDBM50069552
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| Activity |
IC50 = 70000 nM
|
[1] | |||
| Compound Name |
2-Phenylethyl 1-[(4-tert-butylbenzoyl)sulfamoyl]spiro[2H-indole-3,4'-piperidine]-1'-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL506719; BDBM50258483; phenethyl 1-(N-(4-tert-butylbenzoyl)sulfamoyl)spiro[indoline-3,4''-piperidine]-1''-carboxylate
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| Activity |
IC50 = 79000 nM
|
[3] | |||
| Compound Name |
Benzyl 5-((1H-pyrazole-4-carboxamido)methyl)-2-(4-methylphenethyl)piperidine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL466440; BDBM50258508
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| Activity |
IC50 = 81000 nM
|
[3] | |||
| Compound Name |
N-[(2R,3R)-1-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]-2-phenylacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3402511; SCHEMBL18279405; BDBM50069622
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| Activity |
IC50 = 88000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and evaluation of novel amide amino--lactam derivatives as cholesterol absorption inhibitors. Bioorg Med Chem. 2015 May 15;23(10):2353-9. | ||||
| REF 2 | Spiroimidazolidinone NPC1L1 inhibitors. Part 2: structure-activity studies and in vivo efficacy. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6929-32. | ||||
| REF 3 | Spiroimidazolidinone NPC1L1 inhibitors. 1: Discovery by 3D-similarity-based virtual screening. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2965-8. | ||||
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