Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T34239 | Target Info | |||
| Target Name | Protoporphyrinogen oxidase (PPOX) | ||||
| Synonyms |
PPO
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| Target Type | Successful Target | ||||
| Gene Name | PPOX | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 6 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-(4-Chloro-5-ethynoxy-2-fluorophenyl)-3-hydroxy-3a,4,5,6,7,7a-hexahydro-3H-isoindol-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2252345; BDBM50487217
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| Activity |
Ki = 63095.73 nM
|
[1] | |||
| Compound Name |
2-[4-Chloro-5-[(3-chlorophenyl)methoxy]-2-fluorophenyl]-3-prop-2-enoxy-4,5,6,7-tetrahydro-3H-isoindol-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2252333; BDBM50487196
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| Activity |
Ki = 66069.34 nM
|
[1] | |||
| Compound Name |
4-Chlorophthalimide
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Investigative | Compound Info | ||
| Synonyms |
5-Chloroisoindoline-1,3-dione; 5-chloroisoindole-1,3-dione; 4-CHLORO-PHTHALIMIDE; 5-chloro-2,3-dihydro-1H-isoindole-1,3-dione; NSC27008; 4-chloro phthalimide; SCHEMBL658064; 5-chloranylisoindole-1,3-dione; CHEMBL2252336; CTK5D4271; KS-00000JNA; DTXSID40282646; ZINC1634273; ANW-58977; BDBM50487209; MFCD08703319; NSC-27008; AKOS005216105; FS-3638; MP-0664; 5-chloro-1h-isoindole-1,3(2h)-dione; AK-54048; SC-15598; FT-0692464; Z5062; 147C902; A837197
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| Activity |
Ki = 87096.36 nM
|
[1] | |||
| Compound Name |
Ethyl 2-[2-chloro-4-fluoro-5-(1-hydroxy-3-oxo-3a,4,5,6,7,7a-hexahydro-1H-isoindol-2-yl)phenoxy]acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2252343; BDBM50487191
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| Activity |
Ki = 123026.88 nM
|
[1] | |||
| Compound Name |
2-(4-Chloro-2-fluoro-5-methoxyphenyl)-3-hydroxy-3a,4,5,6,7,7a-hexahydro-3H-isoindol-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2252342; BDBM50487206
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| Activity |
Ki = 130970 nM
|
[1] | |||
| Compound Name |
Ethyl 2-[[6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3-yl)-1,3-benzothiazol-2-yl]sulfanyl]propanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1926852; BDBM50359913
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| Activity |
Ki = 173000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Ethyl 4-[[6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3-yl)-1,3-benzothiazol-2-yl]sulfanyl]butanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1926855; BDBM50359916
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| Activity |
Ki = 245000 nM
|
[2] | |||
| Compound Name |
2-(4-Chloro-2-ethoxy-5-nitrophenyl)-3-hydroxy-4,5,6,7-tetrahydro-3H-isoindol-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2252329; BDBM50487214
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| Activity |
Ki = 354813.39 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design, syntheses and 3D-QSAR studies of novel N-phenyl pyrrolidin-2-ones and N-phenyl-1H-pyrrol-2-ones as protoporphyrinogen oxidase inhibitors. Bioorg Med Chem. 2010 Nov 15;18(22):7948-56. | ||||
| REF 2 | Quantitative structure-activity relationships of 1,3,4-thiadiazol-2(3H)-ones and 1,3,4-oxadiazol-2(3H)-ones as human protoporphyrinogen oxidase inhibitors. Bioorg Med Chem. 2012 Jan 1;20(1):296-304. | ||||
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