Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T36741 | Target Info | |||
| Target Name | p53-binding protein Mdm4 (MDM4) | ||||
| Synonyms |
Protein Mdmx; Mdm2-like p53-binding protein; Double minute 4 protein
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|
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| Target Type | Clinical trial Target | ||||
| Gene Name | MDM4 | ||||
| Biochemical Class | MDM2/MDM4 family | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 43 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(E)-3-[1-(4-Chlorophenyl)-2,5-diphenylpyrrol-3-yl]prop-2-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3220114
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Dimethyl 2-[[1-(4-chlorophenyl)-2,5-diphenylpyrrol-3-yl]methylidene]propanedioate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3220109
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-[[1-(4-Chlorophenyl)-2,5-diphenylpyrrol-3-yl]methylidene]propane-1,3-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3220110
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
7-[(2R)-Butan-2-yl]oxy-1-(4-chlorophenyl)-6-ethoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2394408; CHEMBL3683115; BDBM161745; US9051279, 22
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|
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| Activity |
IC50 = 51150 nM
|
[2] | |||
| Compound Name |
5-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-methylphenyl)-2-[2-(1H-indol-3-yl)ethyl]-3-propan-2-yl-4H-pyrrolo[3,4-c]pyrazol-6-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3687233; SCHEMBL14994317; BDBM143341; US8969341, 9
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|
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| Activity |
IC50 = 51168.5 nM
|
[3] | |||
| Compound Name |
Benzyl (4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-4-cycloheptyloxy-1-[[(2S)-1-hydrazinyl-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-[[(2S)-2-[(4-methoxyphenyl)methoxycarbonylamino]propanoyl]amino]-5-oxopentanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2397153; BDBM50436444
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| Activity |
IC50 = 52500 nM
|
[4] | |||
| Compound Name |
(1S)-7-[(2R)-Butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[[4-(dimethylamino)cyclohexyl]methyl-methylamino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2391671; SCHEMBL2391673; CHEMBL3601322; BDBM162023; US9051279, 73a; US9051279, 73b
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|
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| Activity |
IC50 = 52510 nM
|
[2] | |||
| Compound Name |
3-[5-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-methylphenyl)-6-oxo-3-propan-2-yl-4H-pyrrolo[3,4-c]pyrazol-2-yl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3687305; SCHEMBL14993370; BDBM143434; US8969341, 82
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|
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| Activity |
IC50 = 53606.1 nM
|
[3] | |||
| Compound Name |
Ethyl 6-chloro-3-[(cyclohexylmethylamino)-[1-(4-propan-2-ylphenyl)tetrazol-5-yl]methyl]-1H-indole-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087286; BDBM50234679
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|
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| Activity |
Ki = 55000 nM
|
[5] | |||
| Compound Name |
7-[(2R)-Butan-2-yl]oxy-1-[4-chloro-2-(dimethylamino)phenyl]-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2389251; CHEMBL3683103; BDBM161688; US9051279, 6
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|
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| Activity |
IC50 = 57730 nM
|
[2] | |||
| Compound Name |
N-Acylpolyamine (NAPA) scaffold, 11
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL611333; BDBM35064
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|
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| Activity |
IC50 = 59000 nM
|
[6] | |||
| Compound Name |
1-(4-Chlorophenyl)-6-methoxy-2-[4-(oxane-4-carbonyl)cyclohexyl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3650064; SCHEMBL14335435; SCHEMBL16081145; BDBM135934; US8859586, 18
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|
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| Activity |
IC50 = 59900 nM
|
[7] | |||
| Compound Name |
Ethyl 6-chloro-3-[3-(4-chlorophenyl)-1-[(4-chlorophenyl)methyl]indol-2-yl]-1H-indole-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3734842; BDBM50499314
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|
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| Activity |
Ki ~ 60000 nM
|
[8] | |||
| Compound Name |
2-(6-Chloro-1H-indol-3-yl)-1-[(4-chlorophenyl)methyl]-3-phenylindole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735387; BDBM50499313
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|
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| Activity |
Ki ~ 60000 nM
|
[8] | |||
| Compound Name |
Ethyl 6-chloro-3-[1-[(4-chlorophenyl)methyl]-3-phenylindol-2-yl]-1H-indole-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735271; BDBM50499312
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|
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| Activity |
Ki ~ 60000 nM
|
[8] | |||
| Compound Name |
1-(4-Chlorophenyl)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-7-(propan-2-ylamino)-1,4-dihydroisoquinolin-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2390539; CHEMBL3683120; BDBM161802; US9051279, 28
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|
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| Activity |
IC50 = 60150 nM
|
[2] | |||
| Compound Name |
1-(4-Chlorophenyl)-6,7-diethoxy-2-[4-methyl-2-(3-morpholin-4-ylpropoxy)phenyl]-1,4-dihydroisoquinolin-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2392679; CHEMBL3683108; BDBM161703; US9051279, 12
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|
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| Activity |
IC50 = 60640 nM
|
[2] | |||
| Compound Name |
6-[4-(4-Chloro-2-methylphenyl)-5-(5-chloro-2-methylphenyl)-6-oxo-3-propan-2-yl-4H-pyrrolo[3,4-c]pyrazol-2-yl]-1,3-dimethylpyrimidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3687294; SCHEMBL14994630
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|
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| Activity |
IC50 = 61282.3 nM
|
[3] | |||
| Compound Name |
1-(4-Chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2393311; CHEMBL3683119; BDBM161756; US9051279, 26
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|
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| Activity |
IC50 = 62610 nM
|
[2] | |||
| Compound Name |
1-(4-Chlorophenyl)-2-[4-[1-(3-fluorophenyl)-1-hydroxypropyl]cyclohexyl]-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3650073; SCHEMBL14335930; SCHEMBL16081155; BDBM135943; US8859586, 27
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|
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| Activity |
IC50 = 63400 nM
|
[7] | |||
| Compound Name |
7-[(2R)-Butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-(1-pyrrolidin-1-ylethyl)phenyl]-1,4-dihydroisoquinolin-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2394115; CHEMBL3683140; BDBM161941; US9051279, 55
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|
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| Activity |
IC50 = 63710 nM
|
[2] | |||
| Compound Name |
7-[(2R)-Butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-[[4-(dimethylamino)cyclohexyl]-methylamino]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2391764; CHEMBL3683148; BDBM161955; US9051279, 64
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|
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| Activity |
IC50 = 64380 nM
|
[2] | |||
| Compound Name |
N-[4-[1-(4-Chlorophenyl)-6-methoxy-3-oxo-7-propan-2-yloxy-1,4-dihydroisoquinolin-2-yl]cyclohexyl]-N-(oxan-4-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3650059; SCHEMBL14336081; SCHEMBL14406997; BDBM135929; US8859586, 13
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|
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| Activity |
IC50 = 65100 nM
|
[7] | |||
| Compound Name |
1-(4-Chlorophenyl)-6,7-diethoxy-2-[4-methyl-2-(2H-tetrazol-5-ylmethoxy)phenyl]-1,4-dihydroisoquinolin-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2390051; CHEMBL3604660; BDBM161710; US9051279, 14
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|
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| Activity |
IC50 = 65670 nM
|
[2] | |||
| Compound Name |
1-[4-[1-(4-Chlorophenyl)-6-methoxy-3-oxo-7-propan-2-yloxy-1,4-dihydroisoquinolin-2-yl]cyclohexyl]-1-methylurea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3650053; SCHEMBL14336104; SCHEMBL14406932; SCHEMBL16081130; BDBM135923; US8859586, 7
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|
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| Activity |
IC50 = 65700 nM
|
[7] | |||
| Compound Name |
2-[4-[1-[(4-Aminocyclohexyl)amino]ethyl]phenyl]-7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2388431; SCHEMBL2388436; SCHEMBL2391273; CHEMBL3683150; SCHEMBL12258359; BDBM161959; US9051279, 66
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|
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| Activity |
IC50 = 67480 nM
|
[2] | |||
| Compound Name |
4-[[5-[(4-Chlorophenyl)methyl]-1-[(4-methoxyphenyl)methyl]-2-methylimidazol-4-yl]methyl]aniline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2024320; BDBM50382114
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|
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| Activity |
IC50 = 70000 nM
|
[9] | |||
| Compound Name |
2-(4-Acetylcyclohexyl)-1-(4-chlorophenyl)-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3650061; SCHEMBL14336005; SCHEMBL14406887; SCHEMBL16081138; BDBM135931; US8859586, 15; 2-(4-Acetyl-cyclohexyl)-1-(4-chloro-phenyl)-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one
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|
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| Activity |
IC50 = 76100 nM
|
[7] | |||
| Compound Name |
N-[1-[4-[7-[(2R)-Butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-N-piperidin-4-ylacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2403723; CHEMBL3683146; BDBM161953; US9051279, 62
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|
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| Activity |
IC50 = 77380 nM
|
[2] | |||
| Compound Name |
5-(3-Chloro-2-fluorophenyl)-4-(4-chlorophenyl)-2-(2-methoxyphenyl)-4-(2-morpholin-4-yl-2-oxoethyl)-3-propan-2-ylpyrrolo[3,4-c]pyrazol-6-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3687297; SCHEMBL14993859; BDBM143425; US8969341, 74
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|
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| Activity |
IC50 = 80982.4 nM
|
[3] | |||
| Compound Name |
7-[(2R)-Butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-(1H-pyrazol-4-yl)phenyl]-1,4-dihydroisoquinolin-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2393844; CHEMBL3683127; BDBM161841; US9051279, 36
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|
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| Activity |
IC50 = 82030 nM
|
[2] | |||
| Compound Name |
N-[4-[1-(4-Chlorophenyl)-6-methoxy-3-oxo-7-propan-2-yloxy-1,4-dihydroisoquinolin-2-yl]cyclohexyl]-N-(3-hydroxypropyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3650060; SCHEMBL14336053; SCHEMBL14407003; BDBM135930; US8859586, 14
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|
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| Activity |
IC50 = 85100 nM
|
[7] | |||
| Compound Name |
3-Tert-butyl-5-(3-chloro-2-fluorophenyl)-4-(4-chlorophenyl)-2,4-dihydropyrrolo[3,4-c]pyrazol-6-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3691719; SCHEMBL14994032
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|
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| Activity |
IC50 = 88402.1 nM
|
[3] | |||
| Compound Name |
7-[(2R)-Butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2393451; CHEMBL3604661; BDBM161648; US9051279, 1
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|
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| Activity |
IC50 = 90180 nM
|
[2] | |||
| Compound Name |
7-[(2R)-Butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[1-[methyl(piperidin-4-yl)amino]ethyl]phenyl]-1,4-dihydroisoquinolin-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2392225; CHEMBL3683147; BDBM161954; US9051279, 63
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|
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| Activity |
IC50 = 91980 nM
|
[2] | |||
| Compound Name |
N-[4-[1-(4-Chlorophenyl)-6-methoxy-3-oxo-7-propan-2-yloxy-1,4-dihydroisoquinolin-2-yl]cyclohexyl]-3-hydroxy-N-methylpropanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3650055; SCHEMBL14335769; SCHEMBL14406999; SCHEMBL16167635; BDBM135925; US8859586, 9
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|
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| Activity |
IC50 = 92100 nM
|
[7] | |||
| Compound Name |
N-[4-[1-(4-Chlorophenyl)-6-methoxy-3-oxo-7-propan-2-yloxy-1,4-dihydroisoquinolin-2-yl]cyclohexyl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3650050; SCHEMBL14335366; SCHEMBL14406931; BDBM135920; US8859586, 4
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| Activity |
IC50 = 95200 nM
|
[7] | |||
| Compound Name |
N-Acylpolyamine (NAPA) scaffold, 5
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593807; BDBM35058
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|
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| Activity |
IC50 = 96000 nM
|
[6] | |||
| Compound Name |
5-[[6-Amino-1-[[(2S)-1-[(3-amino-3-oxopropyl)-[5-(4-fluorophenyl)pentyl]amino]-4-carboxybutan-2-yl]-[4-(4-bromophenyl)butyl]amino]hexan-2-yl]-(2-spiro[5.5]undecan-3-ylethyl)amino]-4-(4-methylpentanoylamino)pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL594148
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
N-Acylpolyamine (NAPA) scaffold, 12
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL611334; BDBM35065
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
[(2r,5r,6r)-4-[(1s)-2-(Tert-Butylsulfonyl)-1-Cyclopropylethyl]-6-(3-Chlorophenyl)-5-(4-Chlorophenyl)-3-Oxomorpholin-2-Yl]acetic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233140; SCHEMBL14830871; BDBM50007638; HY-12734; CS-0012311; Q27453272
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|
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(2-{[(3r,5r,6s)-1-[(1s)-2-(Tert-Butylsulfonyl)-1-Cyclopropylethyl]-6-(4-Chloro-3-Fluorophenyl)-5-(3-Chlorophenyl)-3-Methyl-2-Oxopiperidin-3-Yl]methyl}-1,3-Thiazol-5-Yl)acetic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
AM-6761; CHEMBL3236357; SCHEMBL21401500; BDBM50008748; Q27453278
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|
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Tert-butyl (S)-1-((S)-1-((S)-3-(1H-indol-3-yl)-1-oxo-1-((S)-1-oxo-3-phenyl-1-(piperidin-1-yl)propan-2-ylamino)propan-2-ylamino)-5-guanidino-1-oxopentan-2-ylamino)-4-methyl-1-oxopentan-2-ylcarbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1256053; BDBM50327208
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|
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| Activity |
IC50 = 192000 nM
|
[12] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 12 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Methylpropyl N-[(2S)-1-[[(2S)-1-[[(2S)-1-(tert-butylamino)-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1256067; BDBM50327210
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|
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| Activity |
IC50 = 300000 nM
|
[12] | |||
| Compound Name |
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S)-1-(benzylamino)-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1256062; BDBM50327209
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|
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| Activity |
IC50 = 307000 nM
|
[12] | |||
| Compound Name |
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S)-1-(tert-butylamino)-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1256064; BDBM50327211
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|
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| Activity |
IC50 = 339000 nM
|
[12] | |||
| Compound Name |
Benzyl N-[(2S)-1-[[(2S)-1-[[(2S)-1-(tert-butylamino)-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1256044; BDBM50327212
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|
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| Activity |
IC50 = 348000 nM
|
[12] | |||
| Compound Name |
((S)-5-((S)-3-(1H-Indol-3-yl)-1-oxo-1-((S)-1-oxo-3-phenyl-1-(piperidin-1-yl)propan-2-ylamino)propan-2-ylamino)-4-(tert-butoxycarbonylamino)-5-oxopentylamino)(amino)methaniminium
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1256051; BDBM50327207
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|
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| Activity |
IC50 = 463000 nM
|
[12] | |||
| Compound Name |
5-[[1-(4-Bromophenyl)-5-tert-butyl-2-phenylpyrrol-3-yl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3220115
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|
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| Activity |
IC50 = 963000 nM
|
[1] | |||
| Compound Name |
5-[[5-Tert-butyl-1-(4-chlorophenyl)-2-phenylpyrrol-3-yl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3220116
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| Activity |
IC50 = 1684000 nM
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[1] | |||
| Compound Name |
5-[[1-(4-Bromophenyl)-2-cyclopropyl-5-phenylpyrrol-3-yl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3220118
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| Activity |
IC50 = 3428000 nM
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[1] | |||
| Compound Name |
5-[[1-(4-Chlorophenyl)-2-cyclopropyl-5-phenylpyrrol-3-yl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3220117
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| Activity |
IC50 = 3486000 nM
|
[1] | |||
| Compound Name |
5-[[1-(4-Chlorophenyl)-5-cyclopropyl-2-phenylpyrrol-3-yl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3220309
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| Activity |
IC50 = 4916000 nM
|
[1] | |||
| Compound Name |
5-[[1-(4-Bromophenyl)-5-cyclopropyl-2-phenylpyrrol-3-yl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3220310
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| Activity |
IC50 = 5322000 nM
|
[1] | |||
| Compound Name |
(1'R,2'R,3S,4'R)-6-Chloro-2'-(3-chlorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-4'-(2,2-dimethylpropyl)-5-fluoro-2-oxospiro[1H-indole-3,3'-cyclopentane]-1'-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347628
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| Activity |
Ki > 50000000 nM
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[13] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
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| REF 1 | Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2-p53 and MDMX-p53 protein-protein interactionsElectronic supplementary information (ESI) available: Experimental details for compound synthesis, analytical data for all compounds and intermediates. Details for the biological evaluation. Further details for the modeling. Table of combustion analysis data. See DOI: 10.1039/c3md00161jClick here for additional data file. Medchemcomm. 2013 Sep 21;4(9):1297-1304. | ||||
| REF 2 | US patent application no. 9051279B2, Substituted isoquinolinones and quinazolinones | ||||
| REF 3 | US patent application no. 8969341B2, Pyrazolopyrrolidine compounds | ||||
| REF 4 | Affinity-based screening of MDM2/MDMX-p53 interaction inhibitors by chemical array: identification of novel peptidic inhibitors. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3802-5. | ||||
| REF 5 | Rational design and synthesis of 1,5-disubstituted tetrazoles as potent inhibitors of the MDM2-p53 interaction. Eur J Med Chem. 2017 Jan 27;126:384-407. | ||||
| REF 6 | N-acylpolyamine inhibitors of HDM2 and HDMX binding to p53. Bioorg Med Chem. 2009 Dec 1;17(23):7884-93. | ||||
| REF 7 | US patent application no. 8859586B2, Cyclohexyl isoquinolinone compounds | ||||
| REF 8 | 2,30-Bis(10H-indole) heterocycles: New p53/MDM2/MDMX antagonists. Bioorg Med Chem Lett. 2015 Dec 15;25(24):5661-6. | ||||
| REF 9 | The central valine concept provides an entry in a new class of non peptide inhibitors of the p53-MDM2 interaction. Bioorg Med Chem Lett. 2012 May 15;22(10):3498-502. | ||||
| REF 10 | Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction. J Med Chem. 2014 Mar 27;57(6):2472-88. | ||||
| REF 11 | Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres. J Med Chem. 2014 Apr 10;57(7):2963-88. | ||||
| REF 12 | Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system. Bioorg Med Chem. 2010 Aug 15;18(16):6099-108. | ||||
| REF 13 | Expanding the horizon of chemotherapeutic targets: From MDM2 to MDMX (MDM4). Medchemcomm. 2011;2:455-65. | ||||
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