Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T37539 | Target Info | |||
| Target Name | B-cell receptor CD22 (CD22) | ||||
| Synonyms |
T-cell surface antigen Leu-14; Siglec-2; Sialic acid-binding Ig-like lectin 2; SIGLEC2; Leu-14; BL-CAM; B-lymphocyte cell adhesion molecule
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| Target Type | Successful Target | ||||
| Gene Name | CD22 | ||||
| Biochemical Class | Immunoglobulin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 8 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2R,4S,5R,6R)-6-[(1R,2R)-3-[[4-(4-Carboxyphenyl)benzoyl]amino]-1,2-dihydroxypropyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL473316; BDBM50274294
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| Activity |
IC50 = 73250 nM
|
[1] | |||
| Compound Name |
(2R,4S,5R,6R)-6-[(1R,2R)-3-Amino-1,2-dihydroxypropyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL503621; BDBM50274239
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| Activity |
IC50 = 85000 nM
|
[1] | |||
| Compound Name |
(2R,4S,5R,6R)-6-[(1R,2R)-3-[(5-Chloro-2-hydroxybenzoyl)amino]-1,2-dihydroxypropyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL453982; BDBM50274280
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| Activity |
IC50 = 115850 nM
|
[1] | |||
| Compound Name |
(2R,4S,5R,6R)-6-[(1R,2R)-3-(Benzylamino)-1,2-dihydroxypropyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL444923; BDBM50274297
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| Activity |
IC50 = 122570 nM
|
[1] | |||
| Compound Name |
(2R,4S,5R,6R)-6-[(1R,2R)-3-Benzamido-1,2-dihydroxypropyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL500885; BDBM50274240
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|
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| Activity |
IC50 = 125160 nM
|
[1] | |||
| Compound Name |
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-(pyridine-3-carbonylamino)propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL502234; BDBM50274281
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| Activity |
IC50 = 132320 nM
|
[1] | |||
| Compound Name |
(2R,4S,5R,6R)-4-Hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL500985; BDBM50274238
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| Activity |
IC50 = 148330 nM
|
[1] | |||
| Compound Name |
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-[(2-hydroxybenzoyl)amino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL502863; BDBM50274279
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|
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| Activity |
IC50 = 192670 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2R,4S,5R,6R)-4-Hydroxy-5-[(2-hydroxyacetyl)amino]-6-[(1R,2R)-1,2,3-trihydroxypropyl]-2-[[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(2-trimethylsilylethoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491269; BDBM50274237
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| Activity |
IC50 = 550000 nM
|
[1] | |||
| Compound Name |
2,6-beta-D-Galactopyranoside
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL456656; BDBM50274236
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| Activity |
IC50 = 683330 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design, synthesis, and structure-affinity relationships of novel series of sialosides as CD22-specific inhibitors. J Med Chem. 2008 Nov 13;51(21):6665-81. | ||||
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