Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T38087 | Target Info | |||
| Target Name | Tankyrase-2 (TNKS-2) | ||||
| Synonyms |
Tankyrase-related protein; Tankyrase-like protein; Tankyrase II; TRF1-interacting ankyrin-related ADP-ribose polymerase 2; TNKL; TANK2; Protein poly-ADP-ribosyltransferase tankyrase-2; Poly [ADP-ribose] polymerase tankyrase-2; Poly [ADP-ribose] polymerase 5B; PARP5B; ARTD6; ADP-ribosyltransferase diphtheria toxin-like 6
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| Target Type | Clinical trial Target | ||||
| Gene Name | TNKS2 | ||||
| Biochemical Class | Glycosyltransferases | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 14 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-(4-Tert-butylphenyl)-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3594135; BDBM50104289
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| Activity |
IC50 = 53000 nM
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[1] | |||
| Compound Name |
2-(2-Fluorophenyl)-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3594123; BDBM50104197
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| Activity |
IC50 = 63000 nM
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[1] | |||
| Compound Name |
2-[4-(2-Fluorophenyl)piperazin-1-yl]-6-methyl-5-propylpyrimidin-4(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1892778; MLS001163032; HMS2831D15; HMS3486I03; BDBM50104202; STK245007; ZINC13119487; AKOS000631047; AKOS002558368; MCULE-4231581810; SMR000499344; ST50332169; 2-[4-(2-fluorophenyl)piperazino]-6-methyl-5-propyl-4(3H)-pyrimidinone; 2-[4-(2-fluorophenyl)-1-piperazinyl]-6-methyl-5-propyl-4(3H)-pyrimidinone; 2-[4-(2-fluorophenyl)piperazinyl]-6-methyl-5-propyl-3-hydropyrimidin-4-one
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| Activity |
IC50 = 63095.73 nM
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[1] | |||
| Compound Name |
2-(2-Methylphenyl)-2,3-dihydro-1H-quinazolin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3594130; BDBM50104297; AKOS001299003; AKOS016872580; MCULE-7583115519
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| Activity |
IC50 = 92000 nM
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[1] | |||
| Compound Name |
2-(2-Methylphenyl)-1H,2H,3H,4H-pyrido[2,3-d]pyrimidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3594122; BDBM50104198; AKOS034747084; MCULE-4725271574; Z968745150
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| Activity |
IC50 = 93000 nM
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[1] | |||
| Compound Name |
4-(4-Carbamoylphenoxy)benzamide
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Investigative | Compound Info | ||
| Synonyms |
4,4'-oxydibenzamide; OUL35; 4,4'-Oxybis[benzamide]; MLS000736992; 4-(4-aminocarbonylphenoxy)benzamide; NSC39047; Oprea1_001354; IFLab1_001185; OUL 35; SCHEMBL3137816; CHEMBL1438938; CTK5B8808; DTXSID10284793; BDBM199181; HMS1415F19; HMS2754A23; ZINC235625; NSC-39047; AKOS001482413; MCULE-8450176580; IDI1_009052; OUL35, >=98% (HPLC); SMR000393949; EU-0000374; SR-01000391101; SR-01000391101-1; 4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carboxamide (OUL35)
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
3-(8-Methyl-4-oxo-1H-quinazolin-2-yl)propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4080163; SCHEMBL19953233; BDBM50234917
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
4-(4-Formyl-phenoxy)-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4287655; 4-(4-Formylphenoxy)-benzamide; 4-(4-formylphenoxy)benzamide; SCHEMBL754740; BDBM50468581; ZINC20297191; A1-11748
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
4-Methoxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
p-Anisamide; p-Methoxybenzamide; 4-Methoxy benzamide; Benzamide, 4-methoxy-; 4-methoxy-benzamide; UNII-Z85FX3977E; CHEMBL449635; Z85FX3977E; MFCD00007995; 4-Methoxybenzamide, 97%; P-methyoxybenzamide; EINECS 222-319-6; BRN 1862847; ACMC-1CJJO; 4-Methoxybenzamide, 98%; Oprea1_456315; 4-10-00-00433 (Beilstein Handbook Reference); KSC225C6N; SCHEMBL201761; SCHEMBL12015238; CTK1C5166; KS-00000FKR; DTXSID40879434; ZINC161203; ACT03272; NSC11139; ANW-27812; BDBM50340090; NSC-11139; STL482885; AKOS000266484; AB00908; CS-W022205; GS-6794; MCULE-3713623573; VZ29332; AC-17055; AK114264; SC-65292; AB0016899; DB-006861; FT-0600843; M1679; ST50824264; 24M939; W-2595; W-106742; Q20059730; Z33546492
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
4-[(2-Fluorophenyl)methoxy]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4208737; OUL35 derivative 32; SCHEMBL20883219; 4-[(2-fluorobenzyl)oxy]benzamide; ZINC7509736; BDBM50452662; STL506080; AKOS017030557; MCULE-5507437194; Z26312097
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
3-(4-Oxo-3,4-dihydroquinazolin-2-yl)propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
3-(4-oxo-1H-quinazolin-2-yl)propanoic acid; 3-(4-Oxo-3,4-dihydro-quinazolin-2-yl)-propionic acid; 3,4-Dihydro-4-oxo-; CHEMBL1892587; NSC251919; Enamine_004755; 2-Quinazolinepropanoic acid, 1,4-dihydro-4-oxo-; MLS000775861; SCHEMBL2718160; SCHEMBL19953232; CTK1H2249; DTXSID00312256; HMS1407I03; HMS2754F07; ALBB-030898; ZINC1556709; BBL030181; BDBM50234922; MFCD03955531; STL374134; STL521303; AKOS000669520; AKOS005202394; AKOS028111280; MCULE-9759862525; NSC-251919; 2-(2-carboxyethyl)quinazolin-4(3h)-one; BS-14054; DA-42158; SMR000370984; 3-(4-hydroxyquinazolin-2-yl)propanoicacid; BB 0304036; FT-0667036; EN300-04546; SR-01000353582; 3-(4-HYDROXYQUINAZOLIN-2-YL)PROPANOIC ACID; SR-01000353582-1; 1,4-DIHYDRO-4-OXO-2-QUINAZOLINEPROPANOIC ACID; 3-(4-Oxo-1,4-dihydroquinazolin-2-yl)propanoic acid; Z56869288; 3-(4-oxo-3,4-dihydro-quinazolin-2-yl)-propionic acid, AldrichCPR
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
4-(4-Carbamoylphenoxy)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4287262; BDBM50468579; ZINC20297208; AKOS009229962; MCULE-8977258216; NE43435; EN300-70101; Z1222331858
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
4-Amino-N-quinolin-8-ylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4063631; SCHEMBL15093487; CTK7D7163; ZINC4933157; BDBM50234918; AKOS000152295; 4-AMINO-N-(QUINOLIN-8-YL)BENZAMIDE
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
2-(2-Chlorophenyl)-1H,2H,3H,4H-pyrido[2,3-d]pyrimidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3594121; BDBM50104199; AKOS032974454; MCULE-7992108588; Z1003791132
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| Activity |
IC50 = 140000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-(3-Phenylmethoxyphenyl)-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3594125; BDBM50104319
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| Activity |
IC50 = 230000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of potent and selective nonplanar tankyrase inhibiting nicotinamide mimics. Bioorg Med Chem. 2015 Aug 1;23(15):4139-4149. | ||||
| REF 2 | 4-(Phenoxy) and 4-(benzyloxy)benzamides as potent and selective inhibitors of mono-ADP-ribosyltransferase PARP10/ARTD10. Eur J Med Chem. 2018 Aug 5;156:93-102. | ||||
| REF 3 | Highly Potent and Isoform Selective Dual Site Binding Tankyrase/Wnt Signaling Inhibitors That Increase Cellular Glucose Uptake and Have Antiproliferative Activity. J Med Chem. 2017 Jan 26;60(2):814-820. | ||||
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