Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T41580 | Target Info | |||
| Target Name | Adrenergic receptor alpha-2B (ADRA2B) | ||||
| Synonyms |
Subtype C2; Alpha-2BAR; Alpha-2B adrenoreceptor; Alpha-2B adrenoceptor; Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptor subtype C2; ADRA2RL1; ADRA2L1
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| Target Type | Successful Target | ||||
| Gene Name | ADRA2B | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Hydroxychloroquine
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Approved | Compound Info | ||
| Synonyms |
Hidroxicloroquina; Hidroxicloroquina [INN-Spanish]; Hydroxychlorochin; Gen-Hydroxychloroquine 200mg Tablets; HCQ; Hydroxychloroguine; Hydroxychloroquine (INN);Hydroxychloroquine [INN:BAN]; Hydroxychloroquine Sulfate (1:1) Salt; Hydroxychloroquinum; Hydroxychloroquinum [INN-Latin]; Idrossiclorochina; Idrossiclorochina [DCIT]; Oxichlorochinum; Oxichloroquine; Oxychlorochin; Oxychloroquine; Plaquenil (TN); Polirreumin; Polirreumin (TN); Quensyl; WIN 1258
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| Activity |
Ki = 72443.6 nM
|
[1] | |||
| Compound Name |
2-[1-(2-Methylsulfonylphenoxy)ethyl]-4,5-dihydro-1H-imidazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956200; BDBM50419882
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| Activity |
Ki = 51286.14 nM
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[2] | |||
| Compound Name |
N-(5-Bromoquinoxalin-6-yl)-4,5-dihydro-1,3-oxazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL73164; BDBM50213346
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| Activity |
Ki = 85113.8 nM
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[3] | |||
| Compound Name |
2-[(1R)-1-(2-Phenylphenoxy)ethyl]-4,5-dihydro-1H-imidazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL242265; BDBM50417353
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| Activity |
EC50 = 100000 nM
|
[4] | |||
| Compound Name |
2-(1-(2-Methoxyphenoxy)ethyl)-4,5-dihydro-1H-imidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956199; BDBM50419881
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| Activity |
EC50 = 100000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug Repurposing. Nature. 2020 Apr 30. doi: 10.1038/s41586-020-2286-9. | ||||
| REF 2 | Might the observed alpha(2A)-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations? Bioorg Med Chem. 2012 Mar 15;20(6):2082-90. | ||||
| REF 3 | Pharmacological evaluation of UK-14,304 analogs at cloned human alpha adrenergic receptors. Bioorg Med Chem Lett. 1995 Oct 5;5(19):2255-8. | ||||
| REF 4 | Fruitful adrenergic alpha(2C)-agonism/alpha(2A)-antagonism combination to prevent and contrast morphine tolerance and dependence. J Med Chem. 2010 Nov 11;53(21):7825-35. | ||||
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