Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T44068 | Target Info | |||
| Target Name | Adrenergic receptor beta-1 (ADRB1) | ||||
| Synonyms |
Beta-1 adrenoreceptor; Beta-1 adrenoceptor; Beta-1 adrenergic receptor; B1AR; ADRB1R
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|
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| Target Type | Successful Target | ||||
| Gene Name | ADRB1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 82 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
6-Chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)quinoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL468176; BDBM50261729
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-{5-[2-(4-{4-[2-((R)-2-Hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenylsulfamoyl}-phenyl)-thiazol-4-yl]-pentyl}-acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL294849; BDBM50091767
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|
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| Activity |
IC50 = 50000 nM
|
[2] | |||
| Compound Name |
N-{4-[2-((R)-2-Hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-4-[3-(4-methoxy-butyl)-2-oxo-imidazolidin-1-yl]-benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL434284; BDBM50075900
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|
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
4-[4-(4-Hexyl-phenyl)-thiazol-2-yl]-N-{4-[2-((R)-2-hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL58241; BDBM50091775
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|
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| Activity |
IC50 = 52000 nM
|
[2] | |||
| Compound Name |
4-(5-Butyl-[1,2,4]oxadiazol-3-yl)-N-{4-[2-((R)-2-hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL286139; BDBM50089460
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|
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| Activity |
IC50 = 55000 nM
|
[4] | |||
| Compound Name |
4-[5-(3-Hydroxy-pentyl)-[1,2,4]oxadiazol-3-yl]-N-{4-[2-((R)-2-hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL34328; BDBM50089462
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|
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| Activity |
IC50 = 56000 nM
|
[4] | |||
| Compound Name |
3-(2-{(R)-2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-thiazol-5-yl)-propionic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL72060; SCHEMBL9305019; BDBM50287797; 3-[2-[(2R)-2-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-thiazol-5-yl]propanoic acid
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|
||||
| Activity |
Ki = 58100 nM
|
[5] | |||
| Compound Name |
N-[4-[[4-[2-[[(2R)-2-Hydroxy-2-pyridin-3-ylethyl]amino]ethyl]phenyl]sulfamoyl]phenyl]pentanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL106487; BDBM50072377
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|
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| Activity |
IC50 = 60000 nM
|
[6] | |||
| Compound Name |
(4-{4-[2-((R)-2-Hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenylsulfamoyl}-phenyl)-carbamic acid propyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL104222; BDBM50072391
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|
||||
| Activity |
IC50 = 60000 nM
|
[6] | |||
| Compound Name |
4-{5-[(4-Fluoro-phenyl)-hydroxy-methyl]-[1,2,4]oxadiazol-3-yl}-N-{4-[2-((R)-2-hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL33224; BDBM50089481
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|
||||
| Activity |
IC50 = 65000 nM
|
[7] | |||
| Compound Name |
N-{4-[2-((R)-2-Hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-4-[5-(4-oxo-pentyl)-[1,2,4]oxadiazol-3-yl]-benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL286800; BDBM50089464
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|
||||
| Activity |
IC50 = 70000 nM
|
[4] | |||
| Compound Name |
(S)-N-(4-(2-(2-Hydroxy-3-phenoxypropylamino)ethyl)phenyl)benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL563872; BDBM50295318
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|
||||
| Activity |
EC50 = 78000 nM
|
[8] | |||
| Compound Name |
Acetic acid;3-[6-[4-[[(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl]amino]butoxy]hexyl]benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL483407; SCHEMBL4813359
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|
||||
| Activity |
EC50 = 79432.82 nM
|
[9] | |||
| Compound Name |
4-[2-[2-[4-(4-Benzylpiperidin-1-yl)phenyl]ethylamino]-1-hydroxyethyl]-2-(hydroxymethyl)phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290975; BDBM50018594
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|
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| Activity |
Ki = 79432.82 nM
|
[10] | |||
| Compound Name |
Chembl4170536
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50288198
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|
||||
| Activity |
Ki = 79432.82 nM
|
[11] | |||
| Compound Name |
N-[6-(6,7-Dihydroxy-1,2,3,4-tetrahydro-isoquinolin-1-ylmethoxy)-naphthalen-2-yl]-4-(3-hexyl-ureido)-benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76403; SCHEMBL8199559; BDBM50093036
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|
||||
| Activity |
IC50 = 80000 nM
|
[12] | |||
| Compound Name |
4-(4-Benzofuran-2-yl-thiazol-2-yl)-N-{4-[2-(2-hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL57908; BDBM50091778
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|
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| Activity |
IC50 = 90000 nM
|
[2] | |||
| Compound Name |
(+/-)-N-[5-(2-Bromo-1-hydroxyethyl)isoxazol-3-yl]methanesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL226292; BDBM50205505
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|
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| Activity |
Ki ~ 100000 nM
|
[13] | |||
| Compound Name |
N-[4-[2-[[(2S)-2-Hydroxy-3-[4-(methanesulfonamido)phenoxy]propyl]amino]ethyl]phenyl]-2-pyridin-2-ylacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL511552; BDBM50259164; (S)-4''-(2-{[2-Hydroxy-3-(4-methylsulfonamidophenoxy)-propyl]amino}ethyl)-2-(2-pyridyl)acetanilide
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|
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| Activity |
EC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
1-[4-[2-[[(2S)-2-Hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]-3-(3-nitrophenyl)thiourea;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1203989
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|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
1-(2-Chlorophenyl)-3-[4-[2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]thiourea;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2448075
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|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Chembl4246134
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462292
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|
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| Activity |
EC50 = 100000 nM
|
[15] | |||
| Compound Name |
Chembl4159562
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50288240
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|
||||
| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
Disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CL 316,243; CL-316243; UNII-CF9MRO9QWW; CL-316243 sodium; CF9MRO9QWW; CL-316,243; 138908-40-4 (sodium salt); CL316243; BTA-243; CL 316243; CL316,243; CHEMBL32590; CL 316243 disodium; SCHEMBL2016430; DTXSID6041004; HMS3260L12; Tox21_500295; AKOS024456637; LP00295; NCGC00093745-01; NCGC00260980-01; AS-16747; EU-0100295; C 5976; 102718-EP2272841A1; 102718-EP2301936A1; Q27275433
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|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
1-(4-(Piperazin-1-yl)phenyl)ethanone
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|
Investigative | Compound Info | ||
| Synonyms |
1-(4-acetylphenyl)piperazine; 4'-Piperazinoacetophenone; 1-(4-piperazin-1-ylphenyl)ethanone; Piperazin-4-ylacetophenone; MFCD00005962; 1-(4-Piperazin-1-yl-phenyl)-ethanone; Ethanone, 1-[4-(1-piperazinyl)phenyl]-; p-Piperazinoacetophenone; 1-(4-(piperazin-1-yl)phenyl)ethan-1-one; 4-piperazinoacetophenone; 1-(4-Piperazin-1-yl-phenyl)ethanone; 1-(p-acetylphenyl)piperazine; CHEMBL166330; 1-[4-(piperazin-1-yl)phenyl]ethanone; 1-[4-(piperazin-1-yl)phenyl]ethan-1-one; 1-acetyl-4-piperazinylbenzene; 4-Piperazinoacetophenone, 94%; 4'-(1-piperazinyl)acetophenone; EINECS 257-332-6; NSC109890; PubChem13361; 4-piperazino acetophenone; ACMC-1AM8S; 4'-piperazino-acetophenone; n-(4-acetylphenyl)piperazine; 4-(4-acetylphenyl)piperazine; BIDD:GT0584; SCHEMBL232986; 1-(4-Acetyl-phenyl)piperazine; 1-(4-acetylphenyl) piperazine; 1-(4-acetylphenyl)-piperazine; 4'-Piperazinoacetophenone, 94%; CTK4J4599; KS-00002BJA; ZINC29076; DTXSID00199584; 4'-(Piperazin-1-yl)acetophenone; STR06370; 7213AB; BBL016329; BDBM50001899; SBB055067; STK400476; AKOS000120540; MCULE-2994216639; NSC-109890; VP70144; 1-(4-piperazine-1-yl-phenyl)-ethanone; 1-[4-(1-Piperazinyl)phenyl]ethanone #; Ethanone,1-[4-(1-piperazinyl)phenyl]-; AK122324; SC-62400; ST042067; TS-02904; 1-[4-(1-Piperazinyl)phenyl]-1-ethanone; AB0118188; DB-018540; CS-0119947; FT-0617368; X-4409; SR-01000059922; SR-01000059922-1; F2190-0511
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|
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| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
1-Cyclohexyl-3-[4-[2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]thiourea;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1203988
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|
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| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Methyl 4-[[4-[2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]carbamothioylamino]benzoate;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1203999
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|
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| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(4-{(R)-2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-phenoxymethyl)-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL41948; BDBM50289569
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|
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| Activity |
Ki ~ 100000 nM
|
[18] | |||
| Compound Name |
1-[4-[2-[[(2S)-2-Hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]-3-phenylurea;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1204383
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|
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| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-[4-[2-[[(2R)-2-Hydroxy-2-pyridin-3-ylethyl]amino]ethyl]phenyl]quinoline-3-sulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107681; BDBM50072389; Isoquinoline-3-sulfonic acid {4-[2-((R)-2-hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-amide
Click to Show/Hide
|
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| Activity |
IC50 = 100000 nM
|
[6] | |||
| Compound Name |
1-(4-Chlorophenyl)-3-[4-[2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]thiourea;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2448072
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-[4-(Methylsulfonylamino)phenyl]-4-phenylpiperazine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL163363; BDBM50001916; 4-Phenyl-piperazine-2-carboxylic acid (4-methanesulfonylamino-phenyl)-amide
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| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
Chembl4173735
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50288200
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|
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| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
1-[4-[2-[[(2S)-2-Hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]-3-(2-nitrophenyl)thiourea;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1203994
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|
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| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-[3'-(6,7-Dihydroxy-1,2,3,4-tetrahydroisoquinoline-1-ylmethyl)-4-biphenylyl]-4-(3-hexylureido)benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL74860; SCHEMBL8191610; BDBM50093042
Click to Show/Hide
|
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| Activity |
IC50 = 100000 nM
|
[12] | |||
| Compound Name |
1-(4-Fluorophenyl)-3-[4-[2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]thiourea;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1204001
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
1-[4-[2-[[(2S)-2-Hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]-3-(4-iodophenyl)thiourea;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1204002
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
1-(3-Chlorophenyl)-3-[4-[2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]thiourea;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2448074
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|
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| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
4-[(S)-2-Hydroxy-3-[1-(3,4-dimethoxyphenylsulfonyl)-4-piperidinylamino]propoxy]-9H-carbazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL71948; SCHEMBL6983825; BDBM50129450; (2S)-1-(9H-carbazol-4-yloxy)-3-[[1-(3,4-dimethoxyphenyl)sulfonylpiperidin-4-yl]amino]propan-2-ol; (S)-1-(9H-Carbazol-4-yloxy)-3-[1-(3,4-dimethoxy-benzenesulfonyl)-piperidin-4-ylamino]-propan-2-ol
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
1-[4-[2-[[(2S)-2-Hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]-3-phenylthiourea;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1203993; SCHEMBL8588198
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-Methyl-5-(phenylsulfamoyl)-2,3-dihydro-1H-indole-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL54885; BDBM50078791
Click to Show/Hide
|
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| Activity |
IC50 = 100000 nM
|
[20] | |||
| Compound Name |
1-[4-[2-[[(2S)-2-Hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]-3-(4-nitrophenyl)thiourea;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1203990
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
3-(Butyl-4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}-ethyl)amino]-1-piperidineyl}anilino)-3-oxopropanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL418600; SCHEMBL6074003; BDBM50098658
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
1-[4-[2-[[(2S)-2-Hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]-3-(2-phenylethyl)thiourea;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1203987
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
4-{(S)-3-[1-(3,4-Dimethoxy-benzenesulfonyl)-piperidin-4-ylamino]-2-hydroxy-propoxy}-1,3-dihydro-benzoimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL306430; SCHEMBL6984549; BDBM50129441
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
Chembl4174295
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
BDBM50288202
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
1-[4-[2-[[(2S)-2-Hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]-3-(4-sulfamoylphenyl)thiourea;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1203991
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Phenyl N-[4-[2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]carbamate;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1203992
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
beta3-AR agonist 2
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL285881; SCHEMBL6074181; BDBM50098659; HY-U00391; CS-7466
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
N-[4-[2-[[(2S)-2-Hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-2-pyrimidin-2-ylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL562154; BDBM50293432; (S)-4''-(2-{[2-Hydroxy-3-(4-hydroxyphenoxy)propyl]amino}ethyl)-2-(pyrimidin-2-yl)acetanilide
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
N-[4-[2-[[(2S)-2-Hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]benzamide;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1203997
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Chembl4166379
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Investigative | Compound Info | ||
| Synonyms |
BDBM50288248
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
4-(4-Benzo[b]thiophen-2-yl-thiazol-2-yl)-N-{4-[2-((R)-2-hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL291306; BDBM50091774
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
Chembl4160295
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Investigative | Compound Info | ||
| Synonyms |
BDBM50288183
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
N-{4-[2-((R)-2-Hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-4-[2-oxo-3-(4,4,4-trifluoro-butyl)-2,3-dihydro-imidazol-1-yl]-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL349689; BDBM50075905
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[3] | |||
| Compound Name |
N-[4-[2-[[(2R)-2-Hydroxy-2-pyridin-3-ylethyl]amino]ethyl]phenyl]-2-phenylethanesulfonamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL104551; BDBM50072381; 2-Phenyl-ethanesulfonic acid {4-[2-((R)-2-hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-amide
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||||
| Activity |
IC50 = 100000 nM
|
[6] | |||
| Compound Name |
Chembl4175397
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Investigative | Compound Info | ||
| Synonyms |
BDBM50288194
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| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
4-[(S)-2-Hydroxy-3-[1-(4-methoxyphenylsulfonyl)-4-piperidinylamino]propoxy]-9H-carbazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL306423; SCHEMBL6983938; BDBM50129442; (2S)-1-(9H-carbazol-4-yloxy)-3-[[1-(4-methoxyphenyl)sulfonylpiperidin-4-yl]amino]propan-2-ol; (S)-1-(9H-Carbazol-4-yloxy)-3-[1-(4-methoxy-benzenesulfonyl)-piperidin-4-ylamino]-propan-2-ol
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||||
| Activity |
EC50 = 100000 nM
|
[19] | |||
| Compound Name |
(2S)-1-[2-(4-Anilinophenyl)ethylamino]-3-phenoxypropan-2-ol;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1204004
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||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Chembl4167532
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50288201
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||||
| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
1-[4-[2-[[(2S)-2-Hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]-3-(4-methoxyphenyl)thiourea;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1204007
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||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Chembl4174691
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50288172
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||||
| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
N-[4-[2-[[(2R)-2-Hydroxy-2-pyridin-3-ylethyl]amino]ethyl]phenyl]propane-2-sulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL104377; BDBM50072386; Propane-2-sulfonic acid {4-[2-((R)-2-hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-amide
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||||
| Activity |
IC50 = 100000 nM
|
[6] | |||
| Compound Name |
N-{4-[2-((R)-2-Hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-4-[2-oxo-3-(3-oxo-3-pyrrolidin-1-yl-propyl)-imidazolidin-1-yl]-benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL79915; BDBM50075909
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|
||||
| Activity |
IC50 = 100000 nM
|
[3] | |||
| Compound Name |
1-[4-[2-[[(2S)-2-Hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]-3-(4-methylphenyl)thiourea;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1204000
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
1-(4-Bromophenyl)-3-[4-[2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]thiourea;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1203998
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|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Chembl4162920
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50288190
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||||
| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
2-(4-{4-[2-Hydroxy-2-(4-hydroxy-3-methanesulfonylamino-phenyl)-ethylamino]-piperidin-1-yl}-benzoylamino)-3-methyl-butyric acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL35282; SCHEMBL6074395; BDBM50098661
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
N-[4-[4-[[(R)-2-Hydroxy-2-[4-hydroxy-3-[(methylsulfonyl)amino]phenyl]ethyl]amino]piperidine-1-yl]benzoyl]-L-phenylalanine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL32599; SCHEMBL6075041; BDBM50098662
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
Chembl4167473
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50288182
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||||
| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
1-Benzyl-3-[4-[2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]thiourea;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1204006
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|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
4-{(S)-2-Hydroxy-3-[1-(4-methoxy-benzenesulfonyl)-piperidin-4-ylamino]-propoxy}-1,3-dihydro-benzoimidazol-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL68685; SCHEMBL6980370; BDBM50129443
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
[(4-{4-[((2R)-2-Hydroxy-2-[4-hydroxy-3-[(methylsulfonyl)amino]phenyl]ethyl)amino]-1-piperidinyl}benzoyl)amino]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL36568; SCHEMBL6074562; BDBM50098654
Click to Show/Hide
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||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
Chembl4170908
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Investigative | Compound Info | ||
| Synonyms |
BDBM50288310
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|
||||
| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
Chembl4170860
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50288191
Click to Show/Hide
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||||
| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
1-[4-[2-[[(2S)-2-Hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]-3-(3-methoxyphenyl)thiourea;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1203996
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(S)-1-[1-(4-Butoxy-benzenesulfonyl)-piperidin-4-ylamino]-3-(9H-carbazol-4-yloxy)-propan-2-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL70230; SCHEMBL6980970; BDBM50129452; (2S)-1-[[1-(4-butoxyphenyl)sulfonylpiperidin-4-yl]amino]-3-(9H-carbazol-4-yloxy)propan-2-ol
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|
||||
| Activity |
EC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
N-[4-[2-[[(2S)-2-Hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]-2-pyridin-2-ylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL466515; BDBM50259165; (S)-4''-(2-{[2-Hydroxy-3-phenoxypropyl]amino}ethyl)-2-(2-pyridyl)acetanilide
Click to Show/Hide
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||||
| Activity |
EC50 = 120000 nM
|
[14] | |||
| Compound Name |
[1-[4-[2-[[2-Hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl]amino]ethyl]phenyl]piperidin-4-yl]-phenylmethanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290977; BDBM50018596
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||||
| Activity |
Ki = 125892.54 nM
|
[10] | |||
| Compound Name |
2-(Hydroxymethyl)-4-[1-hydroxy-2-[2-[4-[4-(3-phenylpropyl)piperidin-1-yl]phenyl]ethylamino]ethyl]phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290976; BDBM50018595
Click to Show/Hide
|
||||
| Activity |
Ki = 125892.54 nM
|
[10] | |||
| Compound Name |
(4-{(R)-2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-phenoxymethyl)-phosphonic acid monoisopropyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL40966; BDBM50289568
Click to Show/Hide
|
||||
| Activity |
Ki = 139000 nM
|
[18] | |||
| Compound Name |
(4-{(R)-2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-phenoxymethyl)-methyl-phosphinic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL39334; BDBM50289565
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|
||||
| Activity |
Ki = 140000 nM
|
[18] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-(4-{(R)-2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-phenoxy)-malonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL290752; BDBM50289566
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||||
| Activity |
Ki = 243000 nM
|
[18] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural modifications of N-arylamide oxadiazoles: Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4267-74. | ||||
| REF 2 | Potent, selective 3-pyridylethanolamine beta3 adrenergic receptor agonists possessing a thiazole benzenesulfonamide pharmacophore. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1971-3. | ||||
| REF 3 | Human beta3 adrenergic receptor agonists containing imidazolidinone and imidazolone benzenesulfonamides. Bioorg Med Chem Lett. 1999 Mar 8;9(5):755-8. | ||||
| REF 4 | Discovery of an orally bioavailable alkyl oxadiazole beta3 adrenergic receptor agonist. Bioorg Med Chem Lett. 2000 Jul 3;10(13):1427-9. | ||||
| REF 5 | BMS-187257, a potent, selective, and novel heterocyclic beta3 adrenergic receptor agonist. Bioorg Med Chem Lett. 1996 Oct 8;6(19):2253-8. | ||||
| REF 6 | 3-Pyridylethanolamines: potent and selective human beta 3 adrenergic receptor agonists. Bioorg Med Chem Lett. 1998 Nov 3;8(21):3087-92. | ||||
| REF 7 | Synthesis and SAR of benzyl and phenoxymethylene oxadiazole benzenesulfonamides as selective beta3 adrenergic receptor agonist antiobesity agents. Bioorg Med Chem Lett. 2000 Jul 3;10(13):1431-4. | ||||
| REF 8 | Discovery of novel thiourea derivatives as potent and selective beta3-adrenergic receptor agonists. Bioorg Med Chem. 2009 Aug 1;17(15):5510-9. | ||||
| REF 9 | Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating arylsulfonamide groups. J Med Chem. 2009 Apr 23;52(8):2280-8. | ||||
| REF 10 | Multivalent design of long-acting (2)-adrenoceptor agonists incorporating biarylamines. Bioorg Med Chem Lett. 2014 Jun 15;24(12):2625-30. | ||||
| REF 11 | Discovery of -Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy. J Med Chem. 2018 Jun 28;61(12):5380-5394. | ||||
| REF 12 | Tetrahydroisoquinoline derivatives containing a benzenesulfonamide moiety as potent, selective human beta3 adrenergic receptor agonists. Bioorg Med Chem Lett. 2000 Oct 16;10(20):2283-6. | ||||
| REF 13 | Novel chiral isoxazole derivatives: synthesis and pharmacological characterization at human beta-adrenergic receptor subtypes. Bioorg Med Chem. 2007 Apr 1;15(7):2533-43. | ||||
| REF 14 | Synthesis and evaluation of novel phenoxypropanolamine derivatives containing acetanilides as potent and selective beta3-adrenergic receptor agonists. Bioorg Med Chem. 2009 May 1;17(9):3283-94. | ||||
| REF 15 | Design and synthesis of aryloxypropanolamine as 3-adrenergic receptor antagonist in cancer and lipolysis. Eur J Med Chem. 2018 Apr 25;150:757-770. | ||||
| REF 16 | (4-Piperidin-1-yl)phenyl amides: potent and selective human beta(3) agonists. J Med Chem. 2001 Apr 26;44(9):1456-66. | ||||
| REF 17 | Synthesis, cardiac electrophysiology, and beta-blocking activity of novel arylpiperazines with potential as class II/III antiarrhythmic agents. J Med Chem. 1992 Feb 21;35(4):743-50. | ||||
| REF 18 | Carboxyl-promoted enhancement of selectivity for the beta3 adrenergic receptor. Negative charge of the sulfonic acid BMS-187413 introduces-beta3 binding selectivity. Bioorg Med Chem Lett. 1997 Jun 17;7(12):1583-8. | ||||
| REF 19 | Cyclic amine sulfonamides as linkers in the design and synthesis of novel human beta(3) adrenergic receptor agonists. Bioorg Med Chem Lett. 2003 Jul 7;13(13):2191-4. | ||||
| REF 20 | Potent, elective human beta3 adrenergic receptor agonists containing a substituted indoline-5-sulfonamide pharmacophore. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1869-74. | ||||
| REF 21 | Discovery of novel acetanilide derivatives as potent and selective beta3-adrenergic receptor agonists. Eur J Med Chem. 2009 Jun;44(6):2533-43. | ||||
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