Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T45262 | Target Info | |||
| Target Name | Corticotropin-releasing factor receptor 1 (CRHR1) | ||||
| Synonyms |
Corticotropin-releasing hormone type 1 receptor; Corticotropin-releasing hormone receptor 1; CRHR1; CRH-R 1; CRF1; CRF-R1; CRF-R; CRF-1 receptor; CRF receptor
Click to Show/Hide
|
||||
| Target Type | Successful Target | ||||
| Gene Name | CRHR1 | ||||
| Biochemical Class | GPCR secretin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-Methyl-2-(2,4,6-trichloro-phenylamino)-thiazole-5-carboxylic acid bis-(2-methoxy-ethyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL128566; SCHEMBL6928652; BDBM50135335
Click to Show/Hide
|
||||
| Activity |
Ki = 51000 nM
|
[1] | |||
| Compound Name |
2-N-(2,6-Diethylphenyl)-6-methyl-4-N-[[4-(trifluoromethyl)phenyl]methyl]-1,3,5-triazine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL343073; BDBM50054242; N-(2,6-Diethyl-phenyl)-6-methyl-N''-(4-trifluoromethyl-benzyl)-[1,3,5]triazine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
Ki = 55000 nM
|
[2] | |||
| Compound Name |
(5-Piperidin-1-ylmethyl-4-trifluoromethyl-thiazol-2-yl)-(2,4,6-trichloro-phenyl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL359828; BDBM50158118
Click to Show/Hide
|
||||
| Activity |
Ki = 55000 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 2-arylaminothiazoles as high-affinity corticotropin-releasing factor 1 receptor (CRF1R) antagonists: synthesis, binding studies and behavioral efficacy. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3997-4000. | ||||
| REF 2 | Rapid microscale synthesis, a new method for lead optimization using robotics and solution phase chemistry: application to the synthesis and optimization of corticotropin-releasing factor1 receptor antagonists. J Med Chem. 1996 Oct 25;39(22):4354-7. | ||||
| REF 3 | Optimization of CRF1R binding affinity of 2-(2,4,6-trichlorophenyl)-4-trifluoromethyl-5-aminomethylthiazoles through rapid and selective parallel synthesis. Bioorg Med Chem Lett. 2005 Jan 17;15(2):431-4. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.