Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T45299 | Target Info | |||
| Target Name | Tissue-type plasminogen activator (PLAT) | ||||
| Synonyms |
TPA; T-plasminogen activator; T-PA; Reteplase; Alteplase
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| Target Type | Successful Target | ||||
| Gene Name | PLAT | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 122 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Argatroban
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|
Approved | Compound Info | ||
| Synonyms |
Acova; Argatrobanum; MMTQAP; MPQA; Novastan; Argatrobanum [Latin]; MITSUBISHI INHIBITOR; MCI 9038; MD 805; MD805; Argatroban (anhydrous); Argatroban [INN:JAN]; GN-1600; MCI-9038; MD-805; MQI-ARG-MCP; (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylic acid; (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[[(3R)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylic acid; (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[[(3S)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylic acid; (2R,4R)-1-[5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylic acid; (2R,4R)-4-Methyl-1-((S)-N(sup 2)-(((RS)-1,2,3,4-tetrahydro-3-methyl-8-quinolyl)sulfonyl)arginyl)pipecolic acid; (2R,4R)-4-Methyl-1[Nalpha-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-L-arginyl)]-2-piperadinecarboxylic acid; (2r,4r)-4-methyl-1-[n2-(3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-l-arginyl]-2-piperidinecarboxylic acid; 21R-Argatroban; 4-methyl-1-(N(2)-(3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl)-2-piperidinecarboxylic acid
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| Activity |
Ki = 87800 nM
|
[1] | |||
| Compound Name |
4-chloro-1-guanidino-7-isoquinolinesulphonamide
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Investigative | Compound Info | ||
| Synonyms |
223671-02-1; 1-GUANIDINO-4-CHLORO-7-SULFAMOYL-ISOQUINOLINE; 4-chloro-1-guanidino-7-isoquinolinesulphonamide; 2-(4-chloro-7-sulfamoylisoquinolin-1-yl)guanidine; CHEMBL227782; SCHEMBL6437735; CTK4E9305; BDBM16132; DTXSID90586545; FXVHAOFNNRNCRJ-UHFFFAOYSA-N; AKOS015966420; 1-guanidino-7-sulfonamidoisoquinoline 6; ACM223671021; 4-chloro-1-guanidino-7-sulphamoylisoquinoline
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| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
6-(N-Phenylcarbamyl)-2-Naphthalenecarboxamidine
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Investigative | Compound Info | ||
| Synonyms |
6-(N-PHENYLCARBAMYL)-2-NAPHTHALENECARBOXAMIDINE; CHEMBL104937; 6-[(Z)-AMINO(IMINO)METHYL]-N-PHENYL-2-NAPHTHAMIDE; 6-carbamimidoyl-N-phenylnaphthalene-2-carboxamide; 1owe; uPa_7; AC1L9L6A; SCHEMBL4324160; ZINC2047486; BDBM50138670; 6-carbamimidoyl-N-phenyl-2-naphthamide; DB01977; 6-Carbamimidoyl-naphthalene-2-carboxylic acid phenylamide
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| Activity |
IC50 = 125000 nM
|
[3] | |||
| Compound Name |
8-(Pyrimidin-2-ylamino)-6-((E)-styryl)-naphthalene-2-carboxamidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL362600; BDBM50157094
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|
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| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
6-Carbamimidoyl-N-[1-(2-methylpropyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]naphthalene-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL109535; BDBM50138669; 6-Carbamimidoyl-naphthalene-2-carboxylic acid (1-isobutyl-1,2,3,4-tetrahydro-isoquinolin-7-yl)-amide
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|
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| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
3-[(E)-2-(5-Chloro-2-guanidino-pyridin-3-yl)-vinyl]-benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL55155; SCHEMBL6433504; BDBM50108380; 3-[(E)-2-[5-chloro-2-(diaminomethylideneamino)pyridin-3-yl]ethenyl]benzoic Acid; 3-[(E)-2-[2-(Diaminomethyleneamino)-5-chloro-3-pyridinyl]ethenyl]benzoic acid
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| Activity |
Ki = 52000 nM
|
[6] | |||
| Compound Name |
N-(4-Amidinophenyl)-2-hydroxy-3-phenylbenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL292300; BDBM50115906; 2-Hydroxy-biphenyl-3-carboxylic acid (4-carbamimidoyl-phenyl)-amide
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| Activity |
Ki = 53000 nM
|
[7] | |||
| Compound Name |
2-[3-[(E)-Styryl]-5-chloro-2-pyridinyl]guanidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL55653; BDBM50108378; N-[5-Chloro-3-((E)-styryl)-pyridin-2-yl]-guanidine
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| Activity |
Ki = 53800 nM
|
[6] | |||
| Compound Name |
2-(5-Nitro-2-hydroxyphenyl)-1H-benzimidazole-5-carboxamidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL92250; BDBM14326; CRA-8249; BDBM50102770; 2-(2-Hydroxy-5-nitro-phenyl)-1H-benzoimidazole-5-carboxamidine; 2-{5-[amino(iminiumyl)methyl]-1H-1,3-benzodiazol-2-yl}-4-nitrobenzen-1-olate
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| Activity |
Ki = 56000 nM
|
[8] | |||
| Compound Name |
Ethyl 1-(diphenoxyphosphoryl)-2-(4-guanidinophenyl)ethylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL239536; SCHEMBL2245991; BDBM50228423; ethyl N-[2-[4-(diaminomethylideneamino)phenyl]-1-diphenoxyphosphorylethyl]carbamate
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| Activity |
IC50 = 57000 nM
|
[9] | |||
| Compound Name |
6-Fluoro-2-[2-hydroxy-3-((S)-2-methyl-cyclohexyloxy)-phenyl]-1H-benzoimidazole-5-carboxamidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL293892; 1o5c; 1o5f; BDBM50115869
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| Activity |
Ki = 58000 nM
|
[10] | |||
| Compound Name |
6-[N-(4-(Aminomethyl)phenyl)carbamyl]-2-naphthalenecarboxamidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL324168; 6-[(Z)-AMINO(IMINO)METHYL]-N-[4-(AMINOMETHYL)PHENYL]-2-NAPHTHAMIDE; uPa_9; N-[4-(aminomethyl)phenyl]-6-carbamimidoylnaphthalene-2-carboxamide; SCHEMBL4330440; ZINC2047485; BDBM50138662; DB02398; Q27093399; N-(4-(aminomethyl)phenyl)-6-carbamimidoyl-2-naphthamide; N-[4-(Aminomethyl)phenyl]-6-amidino-2-naphthalenecarboxamide; 6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-aminomethyl-phenyl)-amide
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| Activity |
Ki = 58400 nM
|
[3] | |||
| Compound Name |
5-[4-[3-(6-Chloro-2-naphthylsulfonyl)propanoyl]piperazino]imidazo[1,2-a]pyridine-2-methanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL259603; BDBM50231646
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|
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| Activity |
Ki ~ 60000 nM
|
[11] | |||
| Compound Name |
2-(1-(3-(6-Chloronaphthalen-2-ylsulfonyl)propanoyl)piperidin-4-yl)-5-methyl-1H-imidazo[1,5-c]imidazol-3(2H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL487105; SCHEMBL948339; BDBM50270656
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| Activity |
Ki ~ 60000 nM
|
[12] | |||
| Compound Name |
2-(1-(3-(6-Chloronaphthalen-2-ylsulfonyl)propanoyl)piperidin-4-yl)-5-(hydroxymethyl)-1H-imidazo[1,5-c]imidazol-3(2H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593482; SCHEMBL947331; BDBM50304620
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|
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| Activity |
Ki ~ 60000 nM
|
[13] | |||
| Compound Name |
(S)-2-(1-(3-(6-Chloronaphthalen-2-ylsulfonyl)-2-hydroxypropanoyl)piperidin-4-yl)-5-methyl-1H-imidazo[1,5-c]imidazol-3(2H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593461; SCHEMBL949001; BDBM50304619
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|
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| Activity |
Ki ~ 60000 nM
|
[13] | |||
| Compound Name |
2-[3-[(E)-4-Methoxystyryl]-5-chloro-2-pyridinyl]guanidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL54894; BDBM50108376; N-{5-Chloro-3-[(E)-2-(4-methoxy-phenyl)-vinyl]-pyridin-2-yl}-guanidine
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|
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| Activity |
Ki = 60100 nM
|
[6] | |||
| Compound Name |
6-Fluoro-2-(2-hydroxy-3-isobutoxy-phenyl)-1H-benzoimidazole-5-carboxamidine
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|
Investigative | Compound Info | ||
| Synonyms |
CRA_10950; CHEMBL62836; SCHEMBL21068046; BDBM14148; APC-10950; BDBM50115865; DB06855; Q27096390; 2-(2-Hydroxy-3-isobutoxyphenyl)-6-fluoro-1H-benzimidazole-5-carboxamidine
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|
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| Activity |
Ki = 61000 nM
|
[10] | |||
| Compound Name |
6-Carbamimidoyl-naphthalene-2-carboxylic acid (3,5-dimethoxy-phenyl)-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL112995; SCHEMBL7340926; BDBM50138678
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|
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| Activity |
IC50 ~ 62000 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(2S)-5-(Diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(2R)-2-phenyl-2-[(2,2,2-trifluoroacetyl)amino]butanoyl]azetidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2370863; BDBM50029508
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|
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| Activity |
IC50 = 62000 nM
|
[14] | |||
| Compound Name |
2-(5-Methoxy-2-hydroxyphenyl)-1H-benzimidazole-5-carboxamidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL96493; 1gi9; SCHEMBL4315525; BDBM50102782
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| Activity |
Ki = 63000 nM
|
[8] | |||
| Compound Name |
2-Carboxyindole-based inhibitor 31
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL440755; SCHEMBL1675165; BDBM15846
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| Activity |
Ki = 64010 nM
|
[15] | |||
| Compound Name |
2-[3-(Phenylethynyl)-5-chloro-2-pyridinyl]guanidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL300030; BDBM50108371; N-(5-Chloro-3-phenylethynyl-pyridin-2-yl)-guanidine
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| Activity |
Ki = 65900 nM
|
[6] | |||
| Compound Name |
Diphenyl N-(benzyloxycarbonyl)amino(4-amidinophenyl)methanephosphonate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL238707; SCHEMBL4295336; BDBM50228415; benzyl N-[(4-carbamimidoylphenyl)-diphenoxyphosphorylmethyl]carbamate; 4-Amidino-alpha-(benzyloxycarbonylamino)benzylphosphonic acid diphenyl ester; diphenyl 1-(N-benzyloxycarbonylamino)-1-(4-amidinophenyl)methanephosphonate; [Benzyloxycarbonylamino-(4-carbamimidoyl-phenyl)-methyl]-phosphonic acid diphenyl ester
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| Activity |
IC50 = 66000 nM
|
[9] | |||
| Compound Name |
3-(6-Chloronaphthalen-2-yl)sulfonyl-N-methyl-N-[1-(2-methylpyridin-4-yl)piperidin-4-yl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL261646; SCHEMBL7013757; BDBM50372526
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| Activity |
Ki = 67000 nM
|
[16] | |||
| Compound Name |
Diphenyl 1-(N-benzyloxycarbonylamino)-1-(4-amidinophenyl)propanephosphonate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL238913; BDBM50228419
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|
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| Activity |
IC50 = 68000 nM
|
[17] | |||
| Compound Name |
N-((1R,2S,5S)-2-(5-Chloro-1H-indole-2-carboxamido)-5-(dimethylcarbamoyl)cyclohexyl)-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-C]pyridine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL479863; SCHEMBL763988; BDBM35743; cis-1,2-diaminocyclohexane derivative, A; Q27459737
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| Activity |
Ki = 68200 nM
|
[18] | |||
| Compound Name |
4-[(E)-(5-Oxo-2-phenyl-1,3-oxazol-4-ylidene)methyl]benzenecarboximidamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1945236; BDBM50363655
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| Activity |
IC50 = 68510 nM
|
[19] | |||
| Compound Name |
2-(3-Methoxy-2-hydroxyphenyl)-1H-benzimidazole-5-carboxamidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL94139; SCHEMBL6289996; BDBM50102788; 2-(2-Hydroxy-3-methoxy-phenyl)-1H-benzoimidazole-5-carboxamidine
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| Activity |
Ki = 69000 nM
|
[8] | |||
| Compound Name |
N-Methyl-2-[[[[(2-naphthyl)sulfonyl]amino]acetyl]amino]-3-[3-(diaminomethyl)phenyl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL346222; BDBM50072848; 3-(3-Diaminomethyl-phenyl)-N-methyl-2-[2-(naphthalene-2-sulfonylamino)-acetylamino]-propionamide
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| Activity |
Ki = 69000 nM
|
[20] | |||
| Compound Name |
2-(3-Methyl-2-hydroxyphenyl)-1H-benzimidazole-5-carboxamidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL92964; BDBM50102772; ZINC13863693; 2-(2-Hydroxy-3-methyl-phenyl)-1H-benzoimidazole-5-carboxamidine
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| Activity |
Ki = 69000 nM
|
[8] | |||
| Compound Name |
6-(2-Phenylcyclopropyl)naphthalene-2-carboximidamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL426433; 6-(2-phenylcyclopropyl)-2-naphthimidamide; SCHEMBL4312320; CTK0J6842; DTXSID50617182; BDBM50157085; 6-(2-Phenyl-cyclopropyl)-naphthalene-2-carboxamidine; 2-Naphthalenecarboximidamide, 6-(2-phenylcyclopropyl)-
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| Activity |
Ki = 69110 nM
|
[4] | |||
| Compound Name |
N-[1-(Piperidinocarbonyl)-2-[4-(diaminomethyl)phenyl]ethyl]-2-[(2-naphthylsulfonyl)amino]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL346607; BDBM50072840
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| Activity |
Ki = 70000 nM
|
[20] | |||
| Compound Name |
6-Fluoro-2-[2-hydroxy-3-(4-methyl-cyclohexyloxy)-phenyl]-1H-benzoimidazole-5-carboxamidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL62509; BDBM50115875
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| Activity |
Ki = 71000 nM
|
[10] | |||
| Compound Name |
2-[3-[(E)-2-Cyclohexylethenyl]-5-chloro-2-pyridinyl]guanidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL53448; BDBM50108386; N-[5-Chloro-3-((E)-2-cyclohexyl-vinyl)-pyridin-2-yl]-guanidine
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| Activity |
Ki = 71500 nM
|
[6] | |||
| Compound Name |
2-{5-[Amino(iminio)methyl]-1H-benzimidazol-2-YL}benzenolate
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Investigative | Compound Info | ||
| Synonyms |
CRA_1144; CHEMBL433501; AC1OARPH; SCHEMBL4315225; CTK0I8807; DTXSID70425524; ZINC6040624; BDBM50100897; DB03643; 2-(2-Hydroxyphenyl)-1H-benzimidazole-5-carboxamidine; Q27094562; 1H-Benzimidazole-5-carboximidamide, 2-(2-hydroxyphenyl)-; 2-{5-[amino(iminio)methyl]-1H-benzimidazol-2-yl}phenolate
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| Activity |
Ki = 75000 nM
|
[8] | |||
| Compound Name |
2-(2-Hydroxy-3-ethoxyphenyl)-6-chloro-1H-benzimidazole-5-carboxamidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL62378; BDBM50115862; 6-Chloro-2-(3-ethoxy-2-hydroxy-phenyl)-1H-benzoimidazole-5-carboxamidine
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| Activity |
Ki ~ 75000 nM
|
[10] | |||
| Compound Name |
2-(2-Hydroxy-3-ethoxyphenyl)-6-fluoro-1H-benzimidazole-5-carboxamidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL62753; BDBM50115853; 2-(3-Ethoxy-2-hydroxy-phenyl)-6-fluoro-1H-benzoimidazole-5-carboxamidine
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| Activity |
Ki ~ 75000 nM
|
[10] | |||
| Compound Name |
6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-ethyl-phenyl)-amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL111660; SCHEMBL7345572; BDBM50138657; ZINC13532771
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| Activity |
Ki = 83900 nM
|
[5] | |||
| Compound Name |
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3,3-dicyclohexylpropanoyl)pyrrolidine-2-carboxamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL555333
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| Activity |
Ki = 84000 nM
|
[21] | |||
| Compound Name |
N-(4-Carbamimidoyl-phenyl)-2-hydroxy-5-nitro-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL62736; BDBM50115879
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| Activity |
Ki = 94000 nM
|
[7] | |||
| Compound Name |
3-Hydroxy-4-iodo-anthracene-2-carboxylic acid (4-guanidino-phenyl)-amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL60478; BDBM50115877
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| Activity |
Ki ~ 95000 nM
|
[7] | |||
| Compound Name |
N-(4-Guanidino-phenyl)-2-hydroxy-5-methoxy-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL64563; BDBM50115904
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| Activity |
Ki ~ 95000 nM
|
[7] | |||
| Compound Name |
N-(4-Guanidino-phenyl)-2-hydroxy-4-methyl-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL64308; BDBM50115884
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|
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| Activity |
Ki ~ 95000 nM
|
[7] | |||
| Compound Name |
4-Bromo-3-hydroxy-anthracene-2-carboxylic acid (4-guanidino-phenyl)-amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL63050; BDBM50115880
Click to Show/Hide
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| Activity |
Ki ~ 95000 nM
|
[7] | |||
| Compound Name |
N-(4-Guanidino-phenyl)-2-hydroxy-3-methyl-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL59690; BDBM50115900
Click to Show/Hide
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| Activity |
Ki ~ 95000 nM
|
[7] | |||
| Compound Name |
N-(4-Guanidino-phenyl)-2-hydroxy-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL303335; BDBM50115883; N-(4-Guanidinophenyl)-2-hydroxybenzamide
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| Activity |
Ki ~ 95000 nM
|
[7] | |||
| Compound Name |
4-Chloro-N-(4-guanidino-phenyl)-2-hydroxy-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL292488; BDBM50115881
Click to Show/Hide
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| Activity |
Ki ~ 95000 nM
|
[7] | |||
| Compound Name |
5-Bromo-N-(4-guanidino-phenyl)-2-hydroxy-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL62414; BDBM50115882
Click to Show/Hide
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| Activity |
Ki ~ 95000 nM
|
[7] | |||
| Compound Name |
4-Ethoxy-N-(4-guanidino-phenyl)-2-hydroxy-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL63038; BDBM50115887
Click to Show/Hide
|
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| Activity |
Ki ~ 95000 nM
|
[7] | |||
| Compound Name |
3-Hydroxy-anthracene-2-carboxylic acid (4-guanidino-phenyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64740; BDBM50115891
Click to Show/Hide
|
||||
| Activity |
Ki ~ 95000 nM
|
[7] | |||
| Compound Name |
3-Chloro-N-(4-guanidino-phenyl)-2-hydroxy-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL294776; BDBM50115892
Click to Show/Hide
|
||||
| Activity |
Ki = 95000 nM
|
[7] | |||
| Compound Name |
N-(4-Guanidino-phenyl)-2-hydroxy-5-methyl-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64841; BDBM50115897; Benzamide,N-[4-[(aminoiminomethyl)amino]phenyl]-2-hydroxy-5-methyl-
Click to Show/Hide
|
||||
| Activity |
Ki ~ 95000 nM
|
[7] | |||
| Compound Name |
2-Hydroxy-biphenyl-3-carboxylic acid (4-guanidino-phenyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL291622; BDBM50115890
Click to Show/Hide
|
||||
| Activity |
Ki ~ 95000 nM
|
[7] | |||
| Compound Name |
N-(4-Guanidino-phenyl)-2-hydroxy-5-nitro-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64463; BDBM50115885
Click to Show/Hide
|
||||
| Activity |
Ki ~ 95000 nM
|
[7] | |||
| Compound Name |
N-(7-Bromo-isoquinolin-1-yl)-guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL321848; Guanidine, N-(7-bromo-1-isoquinolinyl)-; BDBM50147406
Click to Show/Hide
|
||||
| Activity |
Ki = 95100 nM
|
[22] | |||
| Compound Name |
2-Carboxyindole-based inhibitor 28
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL182763; SCHEMBL1674930; BDBM15843
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
1-Guanidino-7-sulfonamidoisoquinoline 14
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL227584; BDBM16140; 3-({4-chloro-1-[(diaminomethylidene)amino]isoquinoline-7-}sulfonamido)propanoic acid; 3-[[4-chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylamino]propanoic acid
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
Cyclic deriv. 35
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL388780; SCHEMBL6434405; BDBM16161; (2R)-1-[4-chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylpiperidine-2-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
Substituted glycine deriv. 16
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL227664; BDBM16142; 2-({4-chloro-1-[(diaminomethylidene)amino]isoquinoline-7-}(methyl)sulfonamido)acetic acid
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
2-Carboxyindole-based inhibitor 24
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL366134; SCHEMBL1675067; BDBM15839
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
(17S,20R)-20-(Benzylsulfonylamino)-N-[(4-carbamimidoylphenyl)methyl]-3,10,19-trioxo-2,5,8,11,18-pentazatetracyclo[20.2.2.25,8.212,15]triaconta-1(25),12,14,22(26),23,27-hexaene-17-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2315239
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[23] | |||
| Compound Name |
2-(4-Diethylamino-2-hydroxy-phenyl)-1H-benzoimidazole-5-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL330460; BDBM50102781; 2-[4-(Diethylamino)-2-hydroxyphenyl]-1H-benzimidazole-5-carboxamidine
Click to Show/Hide
|
||||
| Activity |
Ki = 100000 nM
|
[8] | |||
| Compound Name |
Substituted glycine deriv. 30
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL227666; SCHEMBL6433166; BDBM16156; 4-({4-chloro-1-[(diaminomethylidene)amino]isoquinoline-7-}sulfonamido)oxane-4-carboxylic acid; 4-[[4-chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylamino]oxane-4-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
1-Guanidino-7-sulfonamidoisoquinoline 12
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL224689; SCHEMBL6435605; BDBM16138; 3-({4-chloro-1-[(diaminomethylidene)amino]isoquinoline-7-}sulfonamido)benzoic acid; 3-[[4-chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylamino]benzoic acid
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
1-{[5-(5-Chloro-2-thienyl)isoxazol-3-YL]methyl}-N-(1-isopropylpiperidin-4-YL)-1H-indole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-carboxyindole 22; 2-Carboxyindole Scaffold 1; CHEMBL182746; SCHEMBL1675507; BDBM12372; 2-carboxyindole-based inhibitor 10; ZINC13646511; 7046-EP2269999A1; 7046-EP2270010A1; 7046-EP2272972A1; 7046-EP2272973A1; 7046-EP2275422A1; 7046-EP2277872A1; 7046-EP2281815A1; 7046-EP2281819A1; 7046-EP2284157A1; 7046-EP2284172A1; 7046-EP2289892A1; 7046-EP2292589A1; 7046-EP2292611A1; 7046-EP2292615A1; 7046-EP2295053A1; 7046-EP2295401A2; 7046-EP2295412A1; 7046-EP2295413A1; 7046-EP2298742A1; 7046-EP2301930A1; 7046-EP2301934A1; 7046-EP2305659A1; 7046-EP2305675A1; 7046-EP2308509A1; 7046-EP2308828A2; 7046-EP2308839A1; 7046-EP2308844A2; 7046-EP2308845A2; 7046-EP2308846A2; 7046-EP2308848A1; 7046-EP2308872A1; 7046-EP2308874A1; 7046-EP2308960A1; 7046-EP2311494A1; 7046-EP2311810A1; 7046-EP2314585A1; 7046-EP2315502A1; 7046-EP2316829A1; Q27461417
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
2-[[4-Chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylamino]benzoic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL374623; SCHEMBL6436460; BDBM16137; 1-guanidino-7-sulfonamidoisoquinoline 11; 2-({4-chloro-1-[(diaminomethylidene)amino]isoquinoline-7-}sulfonamido)benzoic acid
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
7-Methoxy-8-[1-(methylsulfonyl)-1H-pyrazol-4-YL]naphthalene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL321944; uPa_13; SCHEMBL5003784; BDBM50147085; DB03046; Q27094011; 7-methoxy-8-(1-(methylsulfonyl)-1H-pyrazol-4-yl)-2-naphthimidamide; 8-(1-Methanesulfonyl-1H-pyrazol-4-yl)-7-methoxy-naphthalene-2-carboxamidine
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[24] | |||
| Compound Name |
(S)-1-(9-Hydroxy-9H-3-aza-fluorene-9-carbonyl)-pyrrolidine-2-carboxylic acid 2-aminomethyl-5-chloro-benzylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL372449; BDBM50164263
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[25] | |||
| Compound Name |
2-Carboxyindole-based inhibitor 33
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185556; BDBM15848
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
Substituted glycine deriv. 17
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228172; BDBM16143; 2-({4-chloro-1-[(diaminomethylidene)amino]isoquinoline-7-}(phenyl)sulfonamido)acetic acid; 2-(N-[4-chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylanilino)acetic acid
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
1-{2-[(4-Chlorophenyl)amino]-2-oxoethyl}-N-(1-isopropylpiperidin-4-YL)-1H-indole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-carboxyindole 27; 2-Carboxyindole Scaffold 45; CHEMBL368238; SCHEMBL1675077; BDBM12400; DB07974; Q27097204; N-(4-Chlorophenyl)-2-(1-isopropyl-4-piperidinylcarbamoyl)-1H-indole-1-acetamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[26] | |||
| Compound Name |
6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-carbamoyl-phenyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL320749; SCHEMBL7340321; BDBM50138675; ZINC13532775
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[5] | |||
| Compound Name |
2-Carboxyindole-based inhibitor 13
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL180695; SCHEMBL1675125; BDBM15828
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
2-Carboxyindole-based inhibitor 7
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL182975; SCHEMBL1674984; BDBM15823
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
1H-Indole-1-acetamide,N-(5-chloro-2-pyridinyl)-2-[[[1-(1-methylethyl)-4-piperidinyl]amino]carbonyl]-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-carboxyindole 29; CHEMBL182597; SCHEMBL1675122; BDBM15867; ZINC14959798; 1-[2-[(5-chloropyridin-2-yl)amino]-2-oxoethyl]-N-(1-propan-2-ylpiperidin-4-yl)indole-2-carboxamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[26] | |||
| Compound Name |
Substituted glycine deriv. 29
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL227976; SCHEMBL7085779; BDBM16155; 1-({4-chloro-1-[(diaminomethylidene)amino]isoquinoline-7-}sulfonamido)cyclohexane-1-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
Naphthalene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
beta-Naphthamidine; Naphthalene-2-carboxamidine; 2-Naphthalenecarboximidamide; 2-Naphthimidamide; CHEMBL105171; 2-naphthamidine; uPa_6; 2-Naphthalenecarboxamidine; SCHEMBL3370031; CTK1H2194; DTXSID40205052; ZINC1442764; BDBM50138663; AKOS009312986; DA-04828; SC-41036; FT-0763708; Q27453295; Z2146514452
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[24] | |||
| Compound Name |
N-Butyl-3-[[4-(diaminomethylideneamino)phenyl]methylamino]imidazo[1,2-a]pyridine-7-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3740183; BDBM50499900
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
N-(6-Carbamimidoyl-naphthalen-2-yl)-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL109287; SCHEMBL5561129; CTK2H3545; DTXSID10457021; BDBM50138672; ZINC13532763; Benzamide, N-(6-cyano-2-naphthalenyl)-
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[5] | |||
| Compound Name |
N-[(4-Chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-(cyclopentylmethyl)glycine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
substituted glycine deriv. 19; CHEMBL227425; SCHEMBL6437774; BDBM16145
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
Cyclic deriv. 34
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228238; BDBM16160
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
2-Carboxyindole 17
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL181849; SCHEMBL1675180; BDBM15857; 1-[(6-chloro-1-benzothiophen-2-yl)methyl]-N-(1-propan-2-ylpiperidin-4-yl)indole-2-carboxamide; 1-[(6-chloro-1-benzothiophen-2-yl)methyl]-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[26] | |||
| Compound Name |
Substituted glycine deriv. 23
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL389056; BDBM16149; (2S)-2-({4-chloro-1-[(diaminomethylidene)amino]isoquinoline-7-}sulfonamido)-3-methylbutanoic acid
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
1-({4-Chloro-1-[(Diaminomethylidene)amino]isoquinolin-7-Yl}sulfonyl)-D-Proline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
cyclic deriv. 33; CHEMBL227990; SCHEMBL6434295; BDBM16159; (2R)-1-[4-chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylpyrrolidine-2-carboxylic Acid; Q27464723; N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-D-proline
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
Substituted glycine deriv. 24
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL266435; BDBM16150
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
Substituted glycine deriv. 25
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL376763; BDBM16151; (2S)-2-[benzyl({4-chloro-1-[(diaminomethylidene)amino]isoquinoline-7-})sulfonamido]propanoic acid
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
2-Carboxyindole-based inhibitor 8
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL183426; SCHEMBL1674982; BDBM15824
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
Substituted glycine deriv. 27
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228170; SCHEMBL6437186; BDBM16153; 1-({4-chloro-1-[(diaminomethylidene)amino]isoquinoline-7-}sulfonamido)cyclobutane-1-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
Substituted glycine deriv. 18
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL227995; BDBM16144; 2-[benzyl({4-chloro-1-[(diaminomethylidene)amino]isoquinoline-7-})sulfonamido]acetic acid; 2-[benzyl-[4-chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylamino]acetic acid
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
Cycloleucine deriv. 43
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL227931; SCHEMBL6448314; BDBM16169
Click to Show/Hide
|
||||
| Activity |
Ki = 108000 nM
|
[2] | |||
| Compound Name |
N-[2-(3-Amidinophenoxy)ethyl]-2'-sulfamoylbiphenyl-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL432306; BDBM50114455; 2''-Sulfamoyl-biphenyl-4-carboxylic acid [2-(3-carbamimidoyl-phenoxy)-ethyl]-amide
Click to Show/Hide
|
||||
| Activity |
IC50 = 109000 nM
|
[27] | |||
| Compound Name |
3-[(R)-3-(4-Formyl-piperazin-1-yl)-2-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-benzamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL322165; BDBM50060023
Click to Show/Hide
|
||||
| Activity |
Ki = 110000 nM
|
[28] | |||
| Compound Name |
2-(5-Methyl-2-hydroxyphenyl)-1H-benzimidazole-5-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL433179; BDBM50102793; ZINC13863688; 2-(2-Hydroxy-5-methyl-phenyl)-1H-benzoimidazole-5-carboxamidine
Click to Show/Hide
|
||||
| Activity |
Ki = 113000 nM
|
[8] | |||
| Compound Name |
{(R)-2-[2-((S)-1-Formyl-4-guanidino-butylcarbamoyl)-azetidin-1-yl]-1-methyl-2-oxo-1-phenyl-ethyl}-carbamic acid tert-butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2370860; BDBM50029507
Click to Show/Hide
|
||||
| Activity |
IC50 = 120000 nM
|
[14] | |||
| Compound Name |
Chembl2332610
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2448530; BDBM50431220
Click to Show/Hide
|
||||
| Activity |
Ki ~ 120000 nM
|
[29] | |||
| Compound Name |
Chembl2332604
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2448529; BDBM50431213
Click to Show/Hide
|
||||
| Activity |
Ki ~ 120000 nM
|
[29] | |||
| Compound Name |
N-[1-(3-Diaminomethyl-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-4-methyl-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL348266; BDBM50072842; N-[1-(Piperidinocarbonyl)-2-[3-(diaminomethyl)phenyl]ethyl]-4-methylbenzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
Ki = 120000 nM
|
[20] | |||
| Compound Name |
N-(5-Phenyl-isoquinolin-1-yl)-guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL111036; BDBM50147426; ZINC26965583
Click to Show/Hide
|
||||
| Activity |
Ki = 123900 nM
|
[22] | |||
| Compound Name |
N-(7-Phenyl-isoquinolin-1-yl)-guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL323241; BDBM50147402; ZINC26960826
Click to Show/Hide
|
||||
| Activity |
Ki = 123900 nM
|
[22] | |||
| Compound Name |
Diphenyl 1-(benzoylamino)-2-(4-guanidinophenyl)-ethanephosphonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL393592; BDBM50228424; N-[2-[4-(diaminomethylideneamino)phenyl]-1-diphenoxyphosphorylethyl]benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 125000 nM
|
[9] | |||
| Compound Name |
N-Isoquinolin-1-yl-guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL321822; Guanidine, N-1-isoquinolinyl-; 2-isoquinolin-1-ylguanidine; 1-(isoquinolin-1-yl)guanidine; SCHEMBL6435471; BDBM50147412
Click to Show/Hide
|
||||
| Activity |
Ki = 126200 nM
|
[22] | |||
| Compound Name |
N-(4-Chloro-isoquinolin-1-yl)-guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL326419; Guanidine, N-(4-chloro-1-isoquinolinyl)-; BDBM50147410
Click to Show/Hide
|
||||
| Activity |
Ki = 128500 nM
|
[22] | |||
| Compound Name |
(2S)-N-[(2S)-5-(Diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(2R)-2-phenyl-2-[(2,2,2-trifluoroacetyl)amino]propanoyl]azetidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2370864; BDBM50029498
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[14] | |||
| Compound Name |
1-(2-Amino-3,3-dicyclohexyl-propionyl)-pyrrolidine-2-carboxylic acid (4-amino-cyclohexylmethyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL289395; BDBM50057826
Click to Show/Hide
|
||||
| Activity |
Ki = 137000 nM
|
[30] | |||
| Compound Name |
2-Biphenyl-3-yl-1H-indole-5-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL321510; BDBM50102776
Click to Show/Hide
|
||||
| Activity |
Ki = 138000 nM
|
[8] | |||
| Compound Name |
N-(5-Bromo-isoquinolin-1-yl)-guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL110358; Guanidine, N-(5-bromo-1-isoquinolinyl)-; BDBM50147428
Click to Show/Hide
|
||||
| Activity |
Ki = 140100 nM
|
[22] | |||
| Compound Name |
6-Fluoro-2-[2-hydroxy-3-((S)-3-methyl-cyclohexyloxy)-phenyl]-1H-benzoimidazole-5-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL294067; BDBM50115866
Click to Show/Hide
|
||||
| Activity |
Ki = 150000 nM
|
[10] | |||
| Compound Name |
3-Hydroxy-4-methoxy-anthracene-2-carboxylic acid (6-guanidino-pyridin-3-yl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL294509; BDBM50115905
Click to Show/Hide
|
||||
| Activity |
Ki = 150000 nM
|
[7] | |||
| Compound Name |
2-(2-Hydroxy-biphenyl-3-yl)-3-methyl-3H-benzoimidazole-5-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL96428; BDBM50102769
Click to Show/Hide
|
||||
| Activity |
Ki = 150000 nM
|
[8] | |||
| Compound Name |
N-(4-Bromo-isoquinolin-1-yl)-guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL323232; Guanidine, N-(4-bromo-1-isoquinolinyl)-; BDBM50147420
Click to Show/Hide
|
||||
| Activity |
Ki = 159200 nM
|
[22] | |||
| Compound Name |
(20S)-20-Benzyl-25-chloro-1,4,13,18,21,23-hexazatricyclo[20.3.1.06,11]hexacosa-6,8,10,22,24-pentaene-3,26-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL329912; SCHEMBL7255204; BDBM50131474
Click to Show/Hide
|
||||
| Activity |
Ki = 165000 nM
|
[31] | |||
| Compound Name |
3-[(R)-3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-benzamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107282; BDBM50060024
Click to Show/Hide
|
||||
| Activity |
Ki = 180000 nM
|
[28] | |||
| Compound Name |
N-[2'-(Aminosulfonyl)-4-biphenylyl]-Nalpha-(3-amidinobenzoyl)-D-phenylglycinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98472; BDBM50106057; 3-Carbamimidoyl-N-[(R)-phenyl-(2''-sulfamoyl-biphenyl-4-ylcarbamoyl)-methyl]-benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[32] | |||
| Compound Name |
(3S)-N-[2'-(Aminosulfonyl)-4-biphenylyl]-2-(3-amidinobenzoyl)-1,2,3,4-tetrahydroisoquinoline-3alpha-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98858; BDBM50106064
Click to Show/Hide
|
||||
| Activity |
IC50 = 180000 nM
|
[32] | |||
| Compound Name |
3-Hydroxy-4-methoxy-anthracene-2-carboxylic acid (4-guanidino-phenyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL303970; BDBM50115898
Click to Show/Hide
|
||||
| Activity |
Ki = 181000 nM
|
[7] | |||
| Compound Name |
(2S)-N-Cyclopentyl-N-methyl-5-[4-(methylamino)phenyl]-2-[(4-propylphenyl)sulfonylamino]pent-4-ynamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL553108; BDBM50076730
Click to Show/Hide
|
||||
| Activity |
Ki = 190000 nM
|
[33] | |||
| Compound Name |
Benzyl 2-[[6-amino-3-chloro-5-(diaminomethylidenecarbamoyl)pyrazin-2-yl]amino]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2013185; BDBM50379660
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 190000 nM
|
[34] | |||
| Compound Name |
3-[(R)-3-(4-Methanesulfonyl-piperazin-1-yl)-2-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-benzamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107392; BDBM50060017
Click to Show/Hide
|
||||
| Activity |
Ki = 190000 nM
|
[28] | |||
| Compound Name |
Benzyl 2-[[6-amino-3-chloro-5-[(Z)-N'-hydroxycarbamimidoyl]pyrazin-2-yl]amino]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2013178; BDBM50379655
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[34] | |||
| Compound Name |
Benzyl 2-[(6-amino-5-carbamimidoyl-3-chloropyrazin-2-yl)amino]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2013181; BDBM50379656
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[34] | |||
| Compound Name |
(2S)-N-Cyclopentyl-N-methyl-5-[4-(methylamino)phenyl]-2-(5,6,7,8-tetrahydronaphthalen-2-ylsulfonylamino)pent-4-ynamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL7587; BDBM50076722
Click to Show/Hide
|
||||
| Activity |
Ki = 200000 nM
|
[33] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 60 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Amiloride
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Amiclaran; Amilorida; Amiloridum; Amipramidin; Amipramizid; Amipramizide; Amiprazidine; Amyloride; Guanamprazin; Guanamprazine; Midamor; Amiloride HCL; Amiloride hydrochloride hydrate; Amiclaran (TN); Amikal (Hydrochloride dihydrate); Amilorida [INN-Spanish]; Amiloride (INN); Amiloride [INN:BAN]; Amiloridum [INN-Latin]; Biduret (TN); Midamor (Hydrochloride dihydrate); MK-870 (Hydrochloride dihydrate); AMILORIDE (SEE ALSO: AMILORIDE HCL (2016-88-8)); N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide; N-Amidino-3,5-diamino-6-chlorpyrazincarboxamid; Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride; 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide; 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide; 3,5-diamino-N-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide; 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide; Amiloride (Na-Ca chanel blocker)
Click to Show/Hide
|
||||
| Activity |
IC50 = 220000 nM
|
[34] | |||
| Compound Name |
Benzamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
benzamidine; Benzimidamide; Benzenecarboximidamide; 618-39-3; Phenylamidine; UNII-KUE3ZY3J1F; NSC 243704; CCRIS 2952; Benzamidine (Protonated); EINECS 210-546-3; KUE3ZY3J1F; CHEMBL20936; CHEBI:41033; PXXJHWLDUBFPOL-UHFFFAOYSA-N; BDN; 1oss; 2ast; 1bra; Benzenecarboxamidine; 1v2m; 1v2j; 1h4w; 1ce5; 1c5o; 2j9n; 1f5k; 1c5p; 1v2v; 1v2s; 1v2l; 1c5z; 1v2u; AC1L1DFX; Lopac-B-6506; ACMC-1B9LG; SCHEMBL9207; Lopac0_000203; MLS001066369; GTPL7566; AC1Q1U98; DTXSID8045012; 1670-14-0 (hydrochloride); ZINC36634; CTK2F5055; 1w80; 1j16; 1j15; MolPort-000-001-395
Click to Show/Hide
|
||||
| Activity |
Ki = 910000 nM
|
[20] | |||
| Compound Name |
(4-guanidino-benzyl)-carbamic acid benzyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL391969; (4-guanidino-benzyl)-carbamic acid benzyl ester
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[9] | |||
| Compound Name |
(2S)-N-Cyclopentyl-N-methyl-5-[4-(methylamino)phenyl]-2-(naphthalen-2-ylsulfonylamino)pent-4-ynamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL415479; BDBM50076724
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[33] | |||
| Compound Name |
(2S)-N-Cyclopentyl-2-[(6-methoxynaphthalen-2-yl)sulfonylamino]-N-methyl-5-[4-(methylamino)phenyl]pent-4-ynamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL7758; BDBM50076725
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[33] | |||
| Compound Name |
(12E)-20-Amino-22-methyl-6-(pyrazol-1-ylmethyl)-9,17-dioxa-1,21,25,29-tetrazatetracyclo[25.2.1.03,8.018,23]triaconta-3(8),4,6,12,18,20,22,27(30),28-nonaen-26-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883423; BDBM50210074
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[35] | |||
| Compound Name |
20-Amino-22-methyl-6-(pyrazol-1-ylmethyl)-9,17-dioxa-1,21,25,29-tetrazatetracyclo[25.2.1.03,8.018,23]triaconta-3(8),4,6,13,18,20,22,27(30),28-nonaen-26-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883788; BDBM50210075
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[35] | |||
| Compound Name |
(13Z)-20-Amino-22-methyl-6-(pyrazol-1-ylmethyl)-9,17-dioxa-1,21,25,29-tetrazatetracyclo[25.2.1.03,8.018,23]triaconta-3(8),4,6,13,18,20,22,27(30),28-nonaen-26-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883461; BDBM50210073
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[35] | |||
| Compound Name |
(8e)-3-Amino-1-Methyl-15-[(1h-Pyrazol-1-Yl)methyl]-7,10,11,12,24,25-Hexahydro-6h,18h,23h-19,22-(Metheno)pyrido[4,3-J][1,9,13,17,18]benzodioxatriazacyclohenicosin-23-One
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884851; BDBM50210127; GBT
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[35] | |||
| Compound Name |
6-Fluoro-2-[2-hydroxy-3-(pyrrolidin-3-yloxy)-phenyl]-1H-benzoimidazole-5-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL61791; BDBM50115863
Click to Show/Hide
|
||||
| Activity |
Ki = 225000 nM
|
[10] | |||
| Compound Name |
3-Hydroxy-4-iodo-anthracene-2-carboxylic acid (6-guanidino-pyridin-3-yl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL59936; BDBM50115899
Click to Show/Hide
|
||||
| Activity |
Ki = 225000 nM
|
[7] | |||
| Compound Name |
2-[[6-Amino-5-[(Z)-N'-hydroxycarbamimidoyl]pyrazin-2-yl]amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2013180; BDBM50379654
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[34] | |||
| Compound Name |
Benzyl 2-[(6-amino-5-carbamoyl-3-chloropyrazin-2-yl)amino]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2013184; BDBM50379659
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[34] | |||
| Compound Name |
(2S)-1-[(2R)-2-Acetamido-2-phenylpropanoyl]-N-[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]azetidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL337799; BDBM50029514
Click to Show/Hide
|
||||
| Activity |
IC50 = 250000 nM
|
[14] | |||
| Compound Name |
2-[(6-Amino-5-carbamimidoyl-3-chloropyrazin-2-yl)amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2013182; SCHEMBL10087502; BDBM50379657
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[34] | |||
| Compound Name |
2-[(6-Amino-5-carbamimidoylpyrazin-2-yl)amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2013183; BDBM50379658
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[34] | |||
| Compound Name |
2-[[6-Amino-5-(diaminomethylidenecarbamoyl)pyrazin-2-yl]amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2013186; BDBM50379662
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[34] | |||
| Compound Name |
2-[[6-Amino-3-chloro-5-(diaminomethylidenecarbamoyl)pyrazin-2-yl]amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1962712; CHEMBL1909781; SCHEMBL10087509; BDBM50356121
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[34] | |||
| Compound Name |
2-[[6-Amino-3-chloro-5-[(Z)-N'-hydroxycarbamimidoyl]pyrazin-2-yl]amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2013179; BDBM50379663
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[34] | |||
| Compound Name |
alpha-(Benzyloxycarbonylamino)-4-guanidinobenzylphosphonic acid diphenyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL379807; CHEMBL1184949; SCHEMBL17126717; BDBM50184643
Click to Show/Hide
|
||||
| Activity |
IC50 = 250000 nM
|
[17] | |||
| Compound Name |
n-(4-Carbamimidoyl-3-choro-phenyl)-2-hydroxy-3-iodo-5-methyl-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62897; N-(4-carbamimidoyl-3-chlorophenyl)-2-hydroxy-3-iodo-5-methylbenzamide; BDBM14159; APC-11421; DB06857; Q27095762; N-(3-Chloro-4-amidinophenyl)-2-hydroxy-3-iodo-5-methylbenzamide; N-{4-[amino(imino)methyl]-3-chlorophenyl}-2-hydroxy-3-iodo-5-methylbenzamide
Click to Show/Hide
|
||||
| Activity |
Ki = 256000 nM
|
[7] | |||
| Compound Name |
3-Bromo-N-(4-guanidino-phenyl)-2-hydroxy-5-methyl-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64578; BDBM50115893; N-(4-Guanidinophenyl)-2-hydroxy-3-bromo-5-methylbenzamide
Click to Show/Hide
|
||||
| Activity |
Ki = 258000 nM
|
[7] | |||
| Compound Name |
2-[3-[(E)-2-(2-Pyridinyl)ethenyl]-5-chloro-2-pyridinyl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL55256; BDBM50108373; N-[5-Chloro-3-((E)-2-pyridin-2-yl-vinyl)-pyridin-2-yl]-guanidine
Click to Show/Hide
|
||||
| Activity |
Ki = 258500 nM
|
[6] | |||
| Compound Name |
6-Fluoro-2-[2-hydroxy-3-(piperidin-3-ylmethoxy)-phenyl]-1H-benzoimidazole-5-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL303978; BDBM50115854
Click to Show/Hide
|
||||
| Activity |
Ki = 263000 nM
|
[10] | |||
| Compound Name |
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-[2-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenyl)acetyl]pyrrolidine-2-carboxamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL555753
Click to Show/Hide
|
||||
| Activity |
Ki = 268000 nM
|
[21] | |||
| Compound Name |
2-(3-Bromo-5-chloro-2-pyridinyl)guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL55125; Guanidine, N-(3-bromo-5-chloro-2-pyridinyl)-; BDBM50108360; N-(3-Bromo-5-chloro-pyridin-2-yl)-guanidine
Click to Show/Hide
|
||||
| Activity |
Ki = 272000 nM
|
[6] | |||
| Compound Name |
6-Fluoro-2-[2-hydroxy-3-(pyrrolidin-2-ylmethoxy)-phenyl]-1H-benzoimidazole-5-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62397; BDBM50115859
Click to Show/Hide
|
||||
| Activity |
Ki = 275000 nM
|
[10] | |||
| Compound Name |
3-Hydroxy-4-isopropoxy-anthracene-2-carboxylic acid (6-guanidino-pyridin-3-yl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL63216; BDBM50115896
Click to Show/Hide
|
||||
| Activity |
Ki = 300000 nM
|
[7] | |||
| Compound Name |
3-Hydroxy-anthracene-2-carboxylic acid (6-guanidino-pyridin-3-yl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64654; BDBM50115894
Click to Show/Hide
|
||||
| Activity |
Ki = 338000 nM
|
[7] | |||
| Compound Name |
2-(3-Phenoxy-5-chloro-2-pyridinyl)guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL53946; BDBM50108370; N-(5-Chloro-3-phenoxy-pyridin-2-yl)-guanidine
Click to Show/Hide
|
||||
| Activity |
Ki = 342000 nM
|
[6] | |||
| Compound Name |
N-Quinolin-2-yl-guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL109751; guanidinoquinoline; 2-quinolin-2-ylguanidine; Guanidine, N-2-quinolinyl-; SCHEMBL6191463; BDBM50147421
Click to Show/Hide
|
||||
| Activity |
Ki = 367000 nM
|
[22] | |||
| Compound Name |
2-Phenyl-1H-benzimidazole-5-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL96917; SCHEMBL14599542; BDBM50100891; ZINC12354847; 2-Phenyl-1H-benzoimidazole-5-carboxamidine; 2-Phenyl-3H-benzoimidazole-5-carboxamidine; 2-phenyl-3H-benzimidazole-5-carboximidamide
Click to Show/Hide
|
||||
| Activity |
Ki = 381000 nM
|
[8] | |||
| Compound Name |
3-[(R)-3-(4-Acetyl-piperazin-1-yl)-2-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-benzamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL322901; BDBM50060029
Click to Show/Hide
|
||||
| Activity |
Ki = 410000 nM
|
[28] | |||
| Compound Name |
6-Fluoro-2-[2-hydroxy-3-((S)-2-methyl-4,4-dimethyl-cyclopentyloxy)-phenyl]-1H-benzoimidazole-5-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL61442; BDBM50115872
Click to Show/Hide
|
||||
| Activity |
Ki = 425000 nM
|
[10] | |||
| Compound Name |
(2S)-N-[(2S)-5-(Diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(3S)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL102552; BDBM50029500
Click to Show/Hide
|
||||
| Activity |
IC50 = 430000 nM
|
[14] | |||
| Compound Name |
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3-phenyl-3-pyridin-4-ylpropanoyl)pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL431675
Click to Show/Hide
|
||||
| Activity |
Ki = 436000 nM
|
[21] | |||
| Compound Name |
3-[(R)-3-(4-Methanesulfonyl-piperazin-1-yl)-3-oxo-2-(2,2,5,7,8-pentamethyl-chroman-6-sulfonylamino)-propyl]-benzamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107743; BDBM50060019
Click to Show/Hide
|
||||
| Activity |
Ki = 470000 nM
|
[28] | |||
| Compound Name |
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-[3-(1,3-benzodioxol-5-yl)-3-pyridin-3-ylpropanoyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL330791
Click to Show/Hide
|
||||
| Activity |
Ki > 500000 nM
|
[21] | |||
| Compound Name |
4-Bromo-3-hydroxy-anthracene-2-carboxylic acid (6-guanidino-pyridin-3-yl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64653; BDBM50115889
Click to Show/Hide
|
||||
| Activity |
Ki = 506000 nM
|
[7] | |||
| Compound Name |
3-Hydroxy-4-isopropoxy-anthracene-2-carboxylic acid (4-guanidino-phenyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL304219; BDBM50115902
Click to Show/Hide
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||||
| Activity |
Ki > 563000 nM
|
[7] | |||
| Compound Name |
N-(4-Guanidino-phenyl)-2-hydroxy-3-iodo-5-methyl-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64164; BDBM50115888; N-(4-Guanidinophenyl)-2-hydroxy-3-iodo-5-methylbenzamide
Click to Show/Hide
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||||
| Activity |
Ki > 563000 nM
|
[7] | |||
| Compound Name |
1-Phenylguanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Phenylguanidine; N-Phenylguanidine; 2-phenylguanidine; GUANIDINE, PHENYL-; alpha-Phenylguanidine; N-Phenyl-guanidine; 1N-amino(immino)methylaniline; CHEMBL14047; EINECS 217-898-7; phenyl guanidine; Monophenylguanidin; N-phenyl guanidine; N-Phenylguanidine #; Guanidine, N-phenyl-; Phenylguanidine mononitrate; SCHEMBL256023; BDBM93095; DTXSID70173836; ALBB-019781; ZINC4276940; BDBM50053620; MFCD00092876; AKOS000266439; MCULE-1696687582; guanidine, N-phenyl-, carbonate(1:1); AM803464; AS-39432; SC-43561; L-4044; J-007368; Q27464460; F2158-0402
Click to Show/Hide
|
||||
| Activity |
Ki = 733000 nM
|
[36] | |||
| Compound Name |
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3-phenyl-3-pyridin-3-ylpropanoyl)pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL333238
Click to Show/Hide
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||||
| Activity |
Ki = 746000 nM
|
[21] | |||
| Compound Name |
4-[(2R)-3-(3-Carbamimidoylphenyl)-2-(naphthalen-2-ylsulfonylamino)propanoyl]-N,N-dimethylpiperazine-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107627; BDBM50060035
Click to Show/Hide
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||||
| Activity |
Ki > 1000000 nM
|
[28] | |||
| Compound Name |
Mupain-1
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3734777; BDBM50499239
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[37] | |||
| Compound Name |
N-[(6-Amino-2-methylpyridin-3-yl)methyl]-1-[[4-(pyrazol-1-ylmethyl)phenyl]methyl]pyrazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884830; BDBM50210072
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[35] | |||
| Compound Name |
(3R,8R,11S,14S,17S,20S,23S,26S,29S,32S)-3-Amino-20-[(1-carbamimidoylpiperidin-4-yl)methyl]-11-(carboxymethyl)-23-(hydroxymethyl)-17,26-bis[(4-hydroxyphenyl)methyl]-29-methyl-14-(2-methylpropyl)-2,10,13,16,19,22,25,28,31-nonaoxo-5,6-dithia-1,9,12,15,18,21,24,27,30-nonazabicyclo[30.3.0]pentatriacontane-8-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735080; BDBM50499240
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[37] | |||
| Compound Name |
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3,3-diphenylpropanoyl)pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL122894
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[21] | |||
| Compound Name |
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3-phenyl-3-pyridin-2-ylpropanoyl)pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL332870
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[21] | |||
| Compound Name |
(3R,8R,11S,14S,17S,20S,23S,26S,29S,32S)-3-Amino-23-benzyl-20-[(1-carbamimidoylpiperidin-4-yl)methyl]-26-[3-(diaminomethylideneamino)propyl]-11-(1H-indol-3-ylmethyl)-17,29-dimethyl-14-(2-methylpropyl)-2,10,13,16,19,22,25,28,31-nonaoxo-5,6-dithia-1,9,12,15,18,21,24,27,30-nonazabicyclo[30.3.0]pentatriacontane-8-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735263; BDBM50499238
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[37] | |||
| Compound Name |
(3R,8R,11S,14S,17S,20S,23S,26S,29S,32S)-3-Amino-11,23-dibenzyl-20-[(1-carbamimidoylpiperidin-4-yl)methyl]-26-[3-(diaminomethylideneamino)propyl]-17,29-dimethyl-14-(2-methylpropyl)-2,10,13,16,19,22,25,28,31-nonaoxo-5,6-dithia-1,9,12,15,18,21,24,27,30-nonazabicyclo[30.3.0]pentatriacontane-8-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735513; BDBM50499241
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[37] | |||
| Compound Name |
Vaborbactam
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
RPX-7009; RPX7009; UNII-1C75676F8V; CHEMBL3317857; 1C75676F8V; Vaborbactam [INN]; RPX 7009; Vaborbactam. RPX7009; Vaborbactam (USAN/INN); Vaborbactam [USAN:INN]; SCHEMBL620289; GTPL10871; Vabomere (vaborbactam + meropenem); EX-A2589; BDBM50089084; MFCD28502176; AKOS032961376; CS-6445; DB12107; SB17184; compound 9f [PMID: 25782055]; NCGC00510003-01; HY-19930; D10998; Q27252228
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[38] | |||
| Compound Name |
2-(4-Guanidynephenyl)-1-phenyl-ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL236081; BDBM50223724
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[39] | |||
| Compound Name |
3-[(R)-3-(4-Methyl-piperazin-1-yl)-2-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-benzamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107911; BDBM50060031
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[28] | |||
| Compound Name |
(3R,8R,11S,14S,17S,20S,23S,26S,29S,32S)-3-Amino-29-(4-aminobutyl)-11,23-dibenzyl-20-[(1-carbamimidoylpiperidin-4-yl)methyl]-26-[3-(diaminomethylideneamino)propyl]-17-methyl-14-(2-methylpropyl)-2,10,13,16,19,22,25,28,31-nonaoxo-5,6-dithia-1,9,12,15,18,21,24,27,30-nonazabicyclo[30.3.0]pentatriacontane-8-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735217; BDBM50499237
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[37] | |||
| Compound Name |
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-[2-(benzylsulfonylamino)-3,3-diphenylpropanoyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL436454; BDBM50056769
Click to Show/Hide
|
||||
| Activity |
Ki = 6700000 nM
|
[40] | |||
| Compound Name |
Tert-butyloxy carbonyl-D-Phe-DL-Pro(5,5-methyl)-Arg-H
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL139910; BDBM50029512
Click to Show/Hide
|
||||
| Activity |
IC50 > 30000000 nM
|
[14] | |||
| Compound Name |
(2S)-N-[(2S)-5-(Diaminomethylideneamino)-2-methyl-1-oxopentan-2-yl]-1-[(2S)-2-(methylamino)-3-phenylpropanoyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL336471; BDBM50029505
Click to Show/Hide
|
||||
| Activity |
IC50 > 30000000 nM
|
[14] | |||
| Compound Name |
(2S)-N-[(2S)-5-(Diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(2R)-2-phenyl-2-[(2,2,2-trifluoroacetyl)amino]propanoyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL138568; BDBM50029502
Click to Show/Hide
|
||||
| Activity |
IC50 > 30000000 nM
|
[14] | |||
| Compound Name |
(2S)-N-[(2S)-5-(Diaminomethylideneamino)-2-methyl-1-oxopentan-2-yl]-1-[(3S)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL343518; BDBM50029503
Click to Show/Hide
|
||||
| Activity |
IC50 > 30000000 nM
|
[14] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
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| REF 16 | Discovery of sulfonylalkylamides: A new class of orally active factor Xa inhibitors. Bioorg Med Chem. 2008 Mar 1;16(5):2243-60. | ||||
| REF 17 | The first potent diphenyl phosphonate KLK4 inhibitors with unexpected binding kinetics. Medchemcomm. 2015;6:1954-8. | ||||
| REF 18 | Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: a novel, potent and orally active direct inhibitor of factor Xa. Bioorg Med Chem. 2009 Feb 1;17(3):1193-206. | ||||
| REF 19 | Discovery and SAR of Novel and Selective Inhibitors of Urokinase Plasminogen Activator (uPA) with an Imidazo[1,2-a]pyridine Scaffold. J Med Chem. 2015 Dec 10;58(23):9238-57. | ||||
| REF 20 | Structural and functional analyses of benzamidine-based inhibitors in complex with trypsin: implications for the inhibition of factor Xa, tPA, and urokinase. J Med Chem. 1998 Dec 31;41(27):5445-56. | ||||
| REF 21 | Synthesis of a series of potent and orally bioavailable thrombin inhibitors that utilize 3,3-disubstituted propionic acid derivatives in the P3 position. J Med Chem. 1997 Oct 24;40(22):3687-93. | ||||
| REF 22 | Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-isoquinolinylguanidines. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3227-30. | ||||
| REF 23 | Development of new cyclic plasmin inhibitors with excellent potency and selectivity. J Med Chem. 2013 Feb 14;56(3):820-31. | ||||
| REF 24 | Interaction with the S1 beta-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3063-8. | ||||
| REF 25 | 9-hydroxyazafluorenes and their use in thrombin inhibitors. J Med Chem. 2005 Apr 7;48(7):2282-93. | ||||
| REF 26 | Factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of neutral P1 substituents. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4191-5. | ||||
| REF 27 | Design, synthesis, and SAR of monobenzamidines and aminoisoquinolines as factor Xa inhibitors. Bioorg Med Chem Lett. 2002 Jun 17;12(12):1657-61. | ||||
| REF 28 | Synthesis and structure-activity relationships of potent thrombin inhibitors: piperazides of 3-amidinophenylalanine. J Med Chem. 1997 Sep 12;40(19):3091-9. | ||||
| REF 29 | Development of a selective peptide macrocycle inhibitor of coagulation factor XII toward the generation of a safe antithrombotic therapy. J Med Chem. 2013 May 9;56(9):3742-6. | ||||
| REF 30 | Potent noncovalent thrombin inhibitors that utilize the unique amino acid D-dicyclohexylalanine in the P3 position. Implications on oral bioavailability and antithrombotic efficacy. J Med Chem. 1997 May 23;40(11):1565-9. | ||||
| REF 31 | Design and synthesis of potent and selective macrocyclic thrombin inhibitors. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2781-4. | ||||
| REF 32 | Design, synthesis, and SAR of amino acid derivatives as factor Xa inhibitors. Bioorg Med Chem Lett. 2001 Nov 19;11(22):2947-50. | ||||
| REF 33 | Thrombin inhibitors based on a propargylglycine template. Bioorg Med Chem Lett. 1999 Apr 5;9(7):1013-8. | ||||
| REF 34 | 2-Amidino analogs of glycine-amiloride conjugates: inhibitors of urokinase-type plasminogen activator. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2635-9. | ||||
| REF 35 | Structure-Guided Design of Novel, Potent, and Selective Macrocyclic Plasma Kallikrein Inhibitors. ACS Med Chem Lett. 2016 Dec 6;8(2):185-190. | ||||
| REF 36 | Selective inhibition of urokinase by substituted phenylguanidines: quantitative structure-activity relationship analyses. J Med Chem. 1990 Nov;33(11):2956-61. | ||||
| REF 37 | Design of Specific Serine Protease Inhibitors Based on a Versatile Peptide Scaffold: Conversion of a Urokinase Inhibitor to a Plasma Kallikrein Inhibitor. J Med Chem. 2015 Nov 25;58(22):8868-76. | ||||
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