Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T46515 | Target Info | |||
| Target Name | Isoleucyl-tRNA synthetase (IARS) | ||||
| Synonyms |
Isoleucine--tRNA ligase, cytoplasmic; Isoleucine--tRNA ligase; IleRS; IRS
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| Target Type | Literature-reported Target | ||||
| Gene Name | IARS | ||||
| Biochemical Class | Carbon-oxygen ligase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 20 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
[(4R)-2-(4-Hydroxy-3-methoxyphenyl)-4,5-dihydro-1,3-oxazol-4-yl]methyl (2S)-2-amino-3-methylpentanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161560
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
2-[[2-(3-Hydroxy-4-methoxyphenyl)acetyl]amino]ethyl (2S)-2-amino-3-methylpentanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161580
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| Activity |
IC50 = 56500 nM
|
[1] | |||
| Compound Name |
[3-(3-Hydroxy-4-methoxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]methyl (2S)-2-amino-3-methylpentanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161555
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| Activity |
IC50 = 57600 nM
|
[1] | |||
| Compound Name |
[(2R,3S,4R,5S)-3,4-Dihydroxy-5-[2-(5-phenyltetrazol-2-yl)ethyl]oxolan-2-yl]methyl (2S,3S)-2-amino-3-methylpentanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161577
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| Activity |
IC50 = 63600 nM
|
[2] | |||
| Compound Name |
2-[(4-Hydroxy-3-methoxybenzoyl)amino]ethyl (2S)-2-amino-3-methylpentanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161582
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| Activity |
IC50 = 64400 nM
|
[1] | |||
| Compound Name |
[3-(4-Hydroxy-3-methoxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]methyl (2S)-2-amino-3-methylpentanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161562
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|
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| Activity |
IC50 = 79000 nM
|
[1] | |||
| Compound Name |
[(2R,3S,4R,5S)-5-[2-[6-(Benzylamino)purin-9-yl]ethyl]-3,4-dihydroxyoxolan-2-yl]methyl (2S,3S)-2-amino-3-methylpentanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161545
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| Activity |
IC50 = 84000 nM
|
[2] | |||
| Compound Name |
[(S)-2-Amino-3-(3H-imidazol-4-yl)-propionyl]-sulfamic acid (2R,3S,4R,5R)-3,4-dihydroxy-5-(4-phenyl-thiazol-2-yl)-tetrahydro-furan-2-ylmethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL126919; BDBM50075057
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
((S)-2-Amino-propionyl)-sulfamic acid (2R,3S,4R,5R)-3,4-dihydroxy-5-(4-phenyl-thiazol-2-yl)-tetrahydro-furan-2-ylmethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL340488; BDBM50075066
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| Activity |
IC50 = 100000 nM
|
[3] | |||
| Compound Name |
((S)-2-Amino-3-phenyl-propionyl)-sulfamic acid (2R,3S,4R,5R)-3,4-dihydroxy-5-(4-phenyl-thiazol-2-yl)-tetrahydro-furan-2-ylmethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL127892; BDBM50075060
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[(3-Hydroxy-4-methoxybenzoyl)amino]ethyl (2S)-2-amino-3-methylpentanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161569
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|
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| Activity |
IC50 = 106000 nM
|
[1] | |||
| Compound Name |
(2S,3S)-2-Amino-N-[[(2R,3S,4R,5S)-5-[2-[6-(benzylamino)purin-9-yl]ethyl]-3,4-dihydroxyoxolan-2-yl]methyl]-N-hydroxy-3-methylpentanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161548
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|
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| Activity |
IC50 ~ 128000 nM
|
[2] | |||
| Compound Name |
[(2R,3S,4R,5S)-5-[(6-Aminopurin-9-yl)methyl]-3,4-dihydroxyoxolan-2-yl]methyl (2S,3S)-2-amino-3-methylpentanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161561
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|
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| Activity |
IC50 ~ 128000 nM
|
[2] | |||
| Compound Name |
(2S,3S)-2-Amino-N-[[(2R,3S,4R,5S)-3,4-dihydroxy-5-[2-(5-phenyltetrazol-2-yl)ethyl]oxolan-2-yl]methyl]-N-hydroxy-3-methylpentanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161544
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|
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| Activity |
IC50 ~ 128000 nM
|
[2] | |||
| Compound Name |
[(2R,3S,4R,5S)-5-[2-(6-Aminopurin-9-yl)ethyl]-3,4-dihydroxyoxolan-2-yl]methyl (2S,3S)-2-amino-3-methylpentanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161540
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|
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| Activity |
IC50 ~ 128000 nM
|
[2] | |||
| Compound Name |
(2S,3S)-2-Amino-N-[[(2R,3S,4R,5S)-5-[2-(6-aminopurin-9-yl)ethyl]-3,4-dihydroxyoxolan-2-yl]methyl]-N-hydroxy-3-methylpentanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161541
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|
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| Activity |
IC50 ~ 128000 nM
|
[2] | |||
| Compound Name |
(2S,3S)-2-Amino-N-[[(2R,3S,4R,5S)-5-[(6-aminopurin-9-yl)methyl]-3,4-dihydroxyoxolan-2-yl]methyl]-N-hydroxy-3-methylpentanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161581
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|
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| Activity |
IC50 ~ 128000 nM
|
[2] | |||
| Compound Name |
(2S,3S)-2-Amino-N-[[(2R,3S,4R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-hydroxysulfamoyl]-3-methylpentanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL605594; BDBM50366872
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|
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| Activity |
IC50 = 132000 nM
|
[4] | |||
| Compound Name |
N-(5'-Adenosyl)-N-hydroxy-L-isoleucinamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161539
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|
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| Activity |
IC50 = 181000 nM
|
[2] | |||
| Compound Name |
L-Isoleucine 5'-adenosyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161574
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|
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| Activity |
IC50 = 183000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-[Hydroxy-[2-(4-hydroxy-3-methoxyphenyl)acetyl]amino]ethyl (2S)-2-amino-3-methylpentanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161551
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|
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| Activity |
IC50 = 228000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Vanilloid and isovanilloid analogues as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases. Bioorg Med Chem Lett. 2001 Apr 23;11(8):965-8. | ||||
| REF 2 | Ester and hydroxamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases. Bioorg Med Chem Lett. 2001 Apr 23;11(8):961-4. | ||||
| REF 3 | Synthesis and structure-activity relationships of a series of novel thiazoles as inhibitors of aminoacyl-tRNA synthetases. Bioorg Med Chem Lett. 1999 Feb 8;9(3):375-80. | ||||
| REF 4 | N-Alkoxysulfamide, N-hydroxysulfamide, and sulfamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1087-92. | ||||
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