Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T46828 | Target Info | |||
| Target Name | Dopamine D5 receptor (D5R) | ||||
| Synonyms |
Dopamine receptor 5; DRD5; D1beta dopamine receptor; D(5)D(1B) dopamine receptor dopamine receptor; D(5) dopamine receptor
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| Target Type | Successful Target | ||||
| Gene Name | DRD5 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-Methylbenzenesulfonate;N-(4-spiro[1,4-diazinan-4-ium-4,4'-2,3-dihydro-1,4-benzoxazin-4-ium]-1-ylbutyl)pyrazolo[1,5-a]pyridine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4060837; BDBM50267794
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| Activity |
Ki ~ 50000 nM
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[1] | |||
| Compound Name |
(1R,2R)-2-(Dipropylamino)-6-fluoro-1-phenyl-2,3-dihydro-1H-inden-5-ol;hydrobromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL557840
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| Activity |
Ki = 54000 nM
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[2] | |||
| Compound Name |
(1R,2R)-6-Fluoro-5-methoxy-N-methyl-1-phenyl-2,3-dihydro-1H-inden-2-amine;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL558364
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| Activity |
Ki = 71000 nM
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[2] | |||
| Compound Name |
(1R,2R)-6-Fluoro-5-methoxy-1-phenyl-N,N-dipropyl-2,3-dihydro-1H-inden-2-amine;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL536044
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| Activity |
Ki = 83000 nM
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[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Development of molecular tools based on the dopamine D 3 receptor ligand FAUC 329 showing inhibiting effects on drug and food maintained behavior. Bioorg Med Chem. 2017 Jul 1;25(13):3491-3499. | ||||
| REF 2 | Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists. J Med Chem. 2005 Apr 7;48(7):2646-54. | ||||
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