Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
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| Target ID | T47623 | Target Info | |||
| Target Name | Heparanase (HPSE) | ||||
| Synonyms |
Hpa1; Heparanase-1; Heparanase 8 kDa subunit; Heparanase 50 kDa subunit; HSE1; HPSE1; HPR1; HPA; HEP protein; Endo-glucoronidase
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| Target Type | Successful Target | ||||
| Gene Name | HPSE | ||||
| Biochemical Class | Glycosylase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Octasodium;[(2R,3R,4R,5S)-4,6-disulfonatooxy-2-(sulfonatooxymethyl)-5-[(2R,3S,4S,5R,6R)-3,4,5-trisulfonatooxy-6-(sulfonatooxymethyl)oxan-2-yl]oxyoxan-3-yl] sulfate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL260220
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| Activity |
Ki = 68300 nM
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[1] | |||
| Compound Name |
3-Hexadecanoyl-5-hydroxymethyl-4-methoxy-5H-furan-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL111508; 4-Me-RK-682; BDBM50104680
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
(2R)-4-Hexadecanoyl-2-(hydroxymethyl)-3-phenylmethoxy-2H-furan-5-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349236; BDBM50431651
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-(3-Nitro-4-phenylsulfanylbenzoyl)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL79948; SCHEMBL5543562; BDBM85275; CTK0I9118; Kl-105; BI-21C7; DTXSID20383928; ZINC1036300; BDBM50145408; CCG-50201; MCULE-4427525577; 2-[3-nitro-4-(phenylthio)benzoyl]benzoic acid; 2-(3-Nitro-4-phenylsulfanyl-benzoyl)-benzoic acid; Benzoic acid, 2-[3-nitro-4-(phenylthio)benzoyl]-; SR-01000639597-1
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| Activity |
IC50 = 300000 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and heparanase inhibitory activity of sulfated mannooligosaccharides related to the antiangiogenic agent PI-88. Bioorg Med Chem. 2008 Jan 15;16(2):699-709. | ||||
| REF 2 | Hit identification of novel heparanase inhibitors by structure- and ligand-based approaches. Bioorg Med Chem. 2013 Apr 1;21(7):1944-51. | ||||
| REF 3 | Rational design and synthesis of novel heparan sulfate mimetic compounds as antiadhesive agents. Bioorg Med Chem Lett. 2004 May 17;14(10):2505-9. | ||||
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