Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T50942 | Target Info | |||
| Target Name | Low-affinity nerve growth factor receptor (NGFR) | ||||
| Synonyms |
p75 ICD; Tumor necrosis factor receptor superfamily member 16; TNFRSF16; P75neurotrophin receptor (p75(NTR)); P75NTR; P75ICD; NGFreceptor; NGF-P75 receptor; NGF receptor; Lowaffinity neurotrophin receptor p75NTR; Low affinity neurotrophin receptor p75NTR; Gp80-LNGFR; CD271; 75kD-neurotrophin receptor
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| Target Type | Successful Target | ||||
| Gene Name | NGFR | ||||
| Biochemical Class | Cytokine receptor | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 1 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
7-Benzamido-4-methyl-9-oxopyrazolo[5,1-b]quinazoline-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
PD 90780; CHEMBL137953; PD-90780; SCHEMBL2727308; BCP16228; ZINC3787086; BDBM50029495; AKOS025142048; NCGC00386708-01; NCGC00386708-02; HY-110166; CS-0033028; PD-90780;PD 90780; 7-benzamido-4-methyl-9-oxo-4H,9H-pyrazolo[3,2-b]quinazoline-2-carboxylic acid
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| Activity |
IC50 = 110000 nM
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[1] | |||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
7,10-Dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridine-8-carbaldehyde
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Investigative | Compound Info | ||
| Synonyms |
Ro 08-2750; CHEMBL1397270; 2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde; 7,10-dimethyl-2,4-dioxo-8-benzo[g]pteridinecarboxaldehyde; SCHEMBL15683182; CTK8G2977; 7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carbaldehyde; AOB4506; DTXSID70590847; HMS3268H04; HMS3413A14; HMS3677A14; BDBM50396070; ZINC13813283; AKOS024457021; NCGC00159546-01; Ro-0282750; Ro-028-2750; HY-108466; B6996; CS-0028854; EC-000.2435; BRD-K00486786-001-01-4; Q27163808
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| Activity |
IC50 = 244000 nM
|
[1] | |||
| Compound Name |
1H-Benz(de)isoquinoline-1,3(2H)-dione, 2-((2-hydroxyethyl)amino)-5-nitro-
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Investigative | Compound Info | ||
| Synonyms |
ALE-0540; UNII-1R1L47BXMJ; 1R1L47BXMJ; CHEMBL440470; Oprea1_821712; SCHEMBL3857057; 2-(2-hydroxyethylamino)-5-nitrobenzo[de]isoquinoline-1,3-dione; ZINC1903557; BDBM50111443; MCULE-3035531849; Q27252774; 2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquinoline-1,3-dione(ALE-0540)
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| Activity |
IC50 > 300000 nM
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[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Targeting the Nerve Growth Factor (NGF) Pathway in Drug Discovery. Potential Applications to New Therapies for Chronic Pain. J Med Chem. 2017 Jan 12;60(1):66-88. | ||||
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