Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T51076 | Target Info | |||
| Target Name | NT-3 growth factor receptor (TrkC) | ||||
| Synonyms |
TrkC tyrosine kinase; Trk-C; TRKC; Neurotrophic tyrosine kinase receptor type 3; NT3 growth factor receptor; GP145TrkC; GP145-TrkC
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|
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| Target Type | Successful Target | ||||
| Gene Name | NTRK3 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 32 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-(2-Phenylpyrrolo[2,3-c]pyridin-1-yl)-N-(pyridin-2-ylmethyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4066024; BDBM50242430
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| Activity |
IC50 = 51000 nM
|
[1] | |||
| Compound Name |
2-[2-(1,3-Oxazol-2-yl)indol-1-yl]-N-(pyridin-2-ylmethyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4101337; BDBM50242472
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| Activity |
IC50 = 53490 nM
|
[1] | |||
| Compound Name |
N-(Pyrimidin-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102371; BDBM50242461
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| Activity |
IC50 = 58440 nM
|
[1] | |||
| Compound Name |
N-(1H-Benzimidazol-2-ylmethyl)-2-[2-(1,3-oxazol-2-yl)indol-1-yl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4080310; SCHEMBL17674272; BDBM50242463
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|
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| Activity |
IC50 = 68160 nM
|
[1] | |||
| Compound Name |
N-(1H-Benzimidazol-2-ylmethyl)-2-[5-fluoro-2-(1,3-oxazol-2-yl)indol-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4104533; BDBM50242456
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|
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| Activity |
IC50 = 68750 nM
|
[1] | |||
| Compound Name |
N-(Pyridin-2-ylmethyl)-2-[2-(1,2-thiazol-5-yl)indol-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094523; BDBM50242471
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|
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| Activity |
IC50 = 70240 nM
|
[1] | |||
| Compound Name |
N-(Imidazo[1,2-a]pyridin-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4103215; BDBM50242481
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|
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| Activity |
IC50 = 71720 nM
|
[1] | |||
| Compound Name |
2-[2-(5-Methylfuran-2-yl)indol-1-yl]-N-(pyridin-2-ylmethyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4103855; BDBM50242479
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|
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| Activity |
IC50 = 73070 nM
|
[1] | |||
| Compound Name |
N-[2-(2-Thiophen-2-ylindol-1-yl)ethyl]pyridine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4088575; BDBM50242455
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|
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| Activity |
IC50 = 80020 nM
|
[1] | |||
| Compound Name |
N-(2-Pyridin-2-ylethyl)-2-thiophen-2-ylindole-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4073807; BDBM50242482
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|
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| Activity |
IC50 = 80270 nM
|
[1] | |||
| Compound Name |
N-(1H-Imidazol-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4101460; BDBM50242460
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|
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| Activity |
IC50 ~ 81010 nM
|
[1] | |||
| Compound Name |
2-(2-Pyridin-3-ylindol-1-yl)-N-(pyridin-2-ylmethyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075690; BDBM50242452
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|
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| Activity |
IC50 ~ 81010 nM
|
[1] | |||
| Compound Name |
N-[(1-Methylimidazol-2-yl)methyl]-2-(2-thiophen-2-ylindol-1-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4073036; BDBM50242480
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|
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| Activity |
IC50 ~ 81010 nM
|
[1] | |||
| Compound Name |
N-(Pyridin-4-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4085988; BDBM50242464
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|
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| Activity |
IC50 ~ 81010 nM
|
[1] | |||
| Compound Name |
2-(2-Phenylpyrrolo[3,2-b]pyridin-1-yl)-N-(pyridin-2-ylmethyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4103783; BDBM50242458
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|
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| Activity |
IC50 ~ 81010 nM
|
[1] | |||
| Compound Name |
2-(2-Pyridin-2-ylindol-1-yl)-N-(pyridin-2-ylmethyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4074640; BDBM50242466
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|
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| Activity |
IC50 ~ 81010 nM
|
[1] | |||
| Compound Name |
N-(1H-Benzimidazol-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4079058; SCHEMBL17674381; BDBM50242470
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|
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| Activity |
IC50 ~ 81010 nM
|
[1] | |||
| Compound Name |
N-[(2-Phenyl-1H-imidazol-5-yl)methyl]-2-(2-thiophen-2-ylindol-1-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4078944; BDBM50242453
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|
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| Activity |
IC50 ~ 81010 nM
|
[1] | |||
| Compound Name |
N-(1,3-Thiazol-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4097075; BDBM50241844
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|
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| Activity |
IC50 ~ 81010 nM
|
[1] | |||
| Compound Name |
N-(Pyridin-3-ylmethyl)-2-(2-thien-2-yl-1H-indol-1-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4064456; BDBM50242489; ZINC15679516; MCULE-8782005941
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|
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| Activity |
IC50 ~ 81010 nM
|
[1] | |||
| Compound Name |
2-(6-Fluoro-2-phenylindol-1-yl)-N-(pyridin-2-ylmethyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4077865; BDBM50242473
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|
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| Activity |
IC50 ~ 81010 nM
|
[1] | |||
| Compound Name |
N-Methyl-N-(pyridin-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4100610; BDBM50242445
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|
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| Activity |
IC50 ~ 81010 nM
|
[1] | |||
| Compound Name |
N-(Pyridin-2-ylmethyl)-2-[2-(1,2-thiazol-3-yl)indol-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4099806; BDBM50242432
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|
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| Activity |
IC50 ~ 81010 nM
|
[1] | |||
| Compound Name |
2-(2-Phenylpyrrolo[3,2-c]pyridin-1-yl)-N-(pyridin-2-ylmethyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4093603; BDBM50242454
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|
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| Activity |
IC50 ~ 81010 nM
|
[1] | |||
| Compound Name |
N-[(5-Phenyl-1H-imidazol-2-yl)methyl]-2-(2-thiophen-2-ylindol-1-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4093738; BDBM50242485
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|
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| Activity |
IC50 ~ 81010 nM
|
[1] | |||
| Compound Name |
N-(Pyridin-2-ylmethyl)-2-[2-(1,3-thiazol-2-yl)indol-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4072919; BDBM50242431
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|
||||
| Activity |
IC50 ~ 81010 nM
|
[1] | |||
| Compound Name |
N-(Pyridin-2-ylmethyl)-2-[2-(1,3-thiazol-5-yl)indol-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4073976; BDBM50241257
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|
||||
| Activity |
IC50 ~ 81010 nM
|
[1] | |||
| Compound Name |
2-(4-Fluoro-2-phenylindol-1-yl)-N-(pyridin-2-ylmethyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4062215; BDBM50242488
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|
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| Activity |
IC50 ~ 81010 nM
|
[1] | |||
| Compound Name |
N-[2-(2-Thiophen-2-ylindol-1-yl)ethyl]pyridine-2-sulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4067321; BDBM50242469
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|
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| Activity |
IC50 ~ 81010 nM
|
[1] | |||
| Compound Name |
2-(5-Fluoro-2-phenylindol-1-yl)-N-(pyridin-2-ylmethyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4095893; BDBM50242484
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|
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| Activity |
IC50 ~ 81010 nM
|
[1] | |||
| Compound Name |
N-(Pyridin-2-ylmethyl)-2-thiophen-2-ylindole-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4080705; BDBM50242499
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|
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| Activity |
IC50 = 81160 nM
|
[1] | |||
| Compound Name |
N-(1H-Imidazol-5-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4065364; BDBM50242486
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|
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| Activity |
IC50 = 120000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design, synthesis and SAR of substituted indoles as selective TrkA inhibitors. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2695-2701. | ||||
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