Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T51487 | Target Info | |||
| Target Name | GABA(A) receptor alpha-1 (GABRA1) | ||||
| Synonyms |
Gamma-aminobutyric acid receptor subunit alpha-1; GABA(A) receptor subunit alpha-1
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| Target Type | Successful Target | ||||
| Gene Name | GABRA1 | ||||
| Biochemical Class | Ligand-gated ion channel | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-[4-(2-Chloro-8-methyl-thieno[2,3-b][1,5]benzoxazepin-4-yl)piperazin-1-yl]-2,2-dimethyl-propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3899169; SCHEMBL14605031; BDBM255474; US9481688, 1; US9481688, 3
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(5S)-1-Methyl-5-prop-2-enyl-5-[3-[3-(trifluoromethyl)diazirin-3-yl]phenyl]-1,3-diazinane-2,4,6-trione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163549; BDBM50395120
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| Activity |
IC50 = 120000 nM
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[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | US patent application no. 9481688B2, (Thieno[2,3-b][1,5]benzoxazepin-4-yl)piperazin-1-yl compounds as dual activity H1 inverse agonists/5-HT2A antagonists | ||||
| REF 2 | Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic. J Med Chem. 2012 Jul 26;55(14):6554-65. | ||||
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