Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T55285 | Target Info | |||
| Target Name | Glycine receptor (GlyR) | ||||
| Synonyms |
Glycine receptor
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| Target Type | Successful Target | ||||
| Gene Name | GLRA1; GLRA2; GLRA3; GLRA4; GLRB | ||||
| Biochemical Class | Neurotransmitter receptor | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 46 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Glycine
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|
Approved | Compound Info | ||
| Synonyms |
Aciport; Aminoazijnzuur; Aminoessigsaeure; Amitone; Corilin; Glicina; Glicoamin; Gly; Glycin; Glycinum; Glycocoll; Glycolixir; Glycosthene; Glykokoll; Glyzin; Hgly; Leimzucker; Padil; Polyglycine; Acide aminoacetique; Acido aminoacetico; Acidum aminoaceticum; Aminoacetic acid; Aminoethanoic acid; An alpha amino acid ester; Glycine [INN]; Hampshire glycine; Polyglycine II; Sucre de gelatine; Acide aminoacetique [INN-French]; Acido aminoacetico [INN-Spanish]; Acidum aminoaceticum [INN-Latin]; GLY (IUPAC abbrev); GLYCINE, ACS; Glicina [INN-Spanish]; Glycinum [INN-Latin]; Gyn-hydralin; L-Glycine; S04-0135; AB-131/40217813; AMINOACETIC ACID 1.5% IN PLASTIC CONTAINER; GLYCINE 1.5% IN PLASTIC CONTAINER; Glycine (JP15/USP); Glycine iron sulphate (1:1); Glycine, homopolymer (VAN); Glycine, labeled with carbon-14; Glycine, non-medical; Glycine-UL-14C hydrochloride; H-Gly-OH; H2N-CH2-COOH; L-alpha-amino acids; (1-13c)glycinato; (15N)Glycine; 2,2-dialkylglycines; 2-Aminoacetic acid
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| Activity | Glycine receptor subunit alpha-1 |
EC50 = 94000 nM
|
[1] | ||
| Compound Name |
5-[(1H-Indol-3-yl)methylidene]-1,3-dimethylimidazolidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2398350; DTXSID80766834; BDBM50436166; (E)-5-((1H-Indol-3-yl)methylene)-1,3-dimethylimidazolidine-2,4-dione
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| Activity | Glycine receptor subunit alpha-3 |
IC50 = 67000 nM
|
[2] | ||
| Compound Name |
(1S,6R,8S,11S,13R,16R,17R)-8-Tert-butyl-6,17-dihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecane-5,18-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL376777; BDBM50208083
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[3] | ||
| Glycine receptor subunit alpha-2 |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(1S,6R,8S,11S,13S,16R,17R)-8-Tert-butyl-6,17-dihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecan-18-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL224937; BDBM50208075
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[3] | ||
| Glycine receptor subunit alpha-2 |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Methyl 2-[(1R,6R,8S,11S,14E)-8-tert-butyl-6-hydroxy-5,15-dioxo-2,4,16-trioxapentacyclo[8.4.2.0^{1,11}.0^{3,7}.0^{7,11}]hexadecan-14-ylidene]propanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL221355; BDBM50208065
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[3] | ||
| Glycine receptor subunit alpha-2 |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[(1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-31-(2-Acetyloxyethyl)-24-phenyl-10,26-dioxa-8,24-diaza-15,31-diazoniaundecacyclo[29.5.2.01,32.02,7.08,36.09,22.013,21.015,19.018,23.025,35.029,34]octatriaconta-2,4,6,12,28-pentaen-15-yl]ethyl acetate;dibromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL395960
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
10-Acetoxy-ginkgolide B
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL222222; BDBM50208087
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[3] | ||
| Glycine receptor subunit alpha-2 |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(1R,6R,8S,11S)-8-Tert-butyl-6,13-dimethoxy-2,4,14,17-tetraoxapentacyclo[8.5.2.0^{1,11}.0^{3,7}.0^{7,11}]heptadecane-5,15,16-trione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL222405; BDBM50208062
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[3] | ||
| Glycine receptor subunit alpha-2 |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(1S,6R,8S,9R,11S,12R,13S,16S,17R)-8-Tert-butyl-6,12,17-trihydroxy-16-methyl-5,15,18-trioxo-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecan-9-yl trifluoromethanesulfonate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL385320; BDBM50208077
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[3] | ||
| Glycine receptor subunit alpha-2 |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
[20-[[Dimethyl-[(4-nitrophenyl)methyl]azaniumyl]methyl]-3,13-diazapentacyclo[11.7.0.03,11.04,9.014,19]icosa-1(20),4,6,8,10,14,16,18-octaen-10-yl]methyl-dimethyl-[(4-nitrophenyl)methyl]azanium;dibromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL229999
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
10-Methoxymethyloxy-ginkgolide A
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL225470; BDBM50208063
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[3] | ||
| Glycine receptor subunit alpha-2 |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(1S,6R,8S,9S,11R,12R,13S,16S,17R)-8-Tert-butyl-6,9,12,17-tetrahydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecane-5,15,18-trione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375821; BDBM50208070
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[3] | ||
| Glycine receptor subunit alpha-2 |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-15,31-Bis[(3,4-dimethoxyphenyl)methyl]-24-phenyl-10,26-dioxa-8,24-diaza-15,31-diazoniaundecacyclo[29.5.2.01,32.02,7.08,36.09,22.013,21.015,19.018,23.025,35.029,34]octatriaconta-2,4,6,12,28-pentaene;dichloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL389120
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
(1R,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-24-Phenyl-15-prop-2-enyl-10,26-dioxa-8,24,31-triaza-15-azoniaundecacyclo[29.5.2.01,32.02,7.08,36.09,22.013,21.015,19.018,23.025,35.029,34]octatriaconta-2,4,6,12,28-pentaene;bromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL244561
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
(1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-15,31-Dibenzyl-24-phenyl-10,26-dioxa-8,24-diaza-15,31-diazoniaundecacyclo[29.5.2.01,32.02,7.08,36.09,22.013,21.015,19.018,23.025,35.029,34]octatriaconta-2,4,6,12,28-pentaene;dibromide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL396705
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
(1R,6R,8S,11S,13S,16R,17R)-8-Tert-butyl-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecane-6,17-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL223761; BDBM50208089
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[3] | ||
| Glycine receptor subunit alpha-2 |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1,23,14-Dianhydro-Ginkgolide C
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL412540; 1,2;3,14-dianhydro-ginkgolide C; BDBM50208080
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[3] | ||
| Glycine receptor subunit alpha-2 |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Trimethyl-[[20-[(trimethylazaniumyl)methyl]-3,13-diazapentacyclo[11.7.0.03,11.04,9.014,19]icosa-1(20),4,6,8,10,14,16,18-octaen-10-yl]methyl]azanium;diiodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL382243
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
(1R,9R,18S,19S,21R,22R,23R,25R,32S,34R,35R,36S)-24-Phenyl-10,26-dioxa-8,15,24,31-tetraazaundecacyclo[29.5.2.0^{1,32}.0^{2,7}.0^{8,36}.0^{9,22}.0^{13,21}.0^{15,19}.0^{18,23}.0^{25,35}.0^{29,34}]octatriaconta-2,4,6,12,28-pentaene
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL388212; BDBM50220040
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
(1S,6R,8S,11R,12R,13S,16S,17R)-8-Tert-butyl-6,12,17-trihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecane-5,9,15,18-tetrone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL222534; BDBM50208091
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
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[3] | ||
| Glycine receptor subunit alpha-2 |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
[(1R,6R,8S,11S,13S,16R,17S)-8-Tert-butyl-16-methyl-5,15,18-trioxo-2,4,14,19-tetraoxahexacyclo[8.7.2.01,11.03,7.07,11.013,17]nonadecan-6-yl] acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL412384; BDBM50208059
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
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[3] | ||
| Glycine receptor subunit alpha-2 |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
(1S,2R,3S,6S,8S,10R)-10-Tert-butyl-2-hydroxy-3-methyl-5,13,15-trioxapentacyclo[7.5.2.0^{1,8}.0^{2,6}.0^{8,12}]hexadecane-4,14,16-trione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL221769; BDBM50208072
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
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[3] | ||
| Glycine receptor subunit alpha-2 |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
(1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-15,31-Bis[(4-bromophenyl)methyl]-24-phenyl-10,26-dioxa-8,24-diaza-15,31-diazoniaundecacyclo[29.5.2.01,32.02,7.08,36.09,22.013,21.015,19.018,23.025,35.029,34]octatriaconta-2,4,6,12,28-pentaene;dibromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL388046
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
(2E)-2-[(1S,9Z,11S,13S,17R,18R,20R,27S,29R,30R,31S)-14,26-Bis[(3,4-dimethoxyphenyl)methyl]-19-phenyl-21-oxa-8,19-diaza-14,26-diazoniadecacyclo[24.5.2.211,14.01,27.02,7.08,31.010,18.013,17.020,30.024,29]pentatriaconta-2,4,6,9,23-pentaen-35-ylidene]ethanol;dichloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL388049
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
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[1] | ||
| Compound Name |
Methyl 2-[(1R,6R,8S,11S,14R)-8-tert-butyl-6-hydroxy-5,15-dioxo-2,4,16-trioxapentacyclo[8.4.2.0^{1,11}.0^{3,7}.0^{7,11}]hexadecan-14-yl]propanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL225471; BDBM50208088
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
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[3] | ||
| Glycine receptor subunit alpha-2 |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
(1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-15,31-Di(cyclohex-2-en-1-yl)-24-phenyl-10,26-dioxa-8,24-diaza-15,31-diazoniaundecacyclo[29.5.2.01,32.02,7.08,36.09,22.013,21.015,19.018,23.025,35.029,34]octatriaconta-2,4,6,12,28-pentaene;dibromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL231056
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
(1S,6R,8S,9S,11R,12R,13S,16S,17R)-8-Tert-butyl-6,12,17-trihydroxy-16-methyl-5,15,18-trioxo-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecan-9-yl 2-phenylacetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL387106; BDBM50208092
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
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[3] | ||
| Glycine receptor subunit alpha-2 |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
[20-[[Dimethyl(prop-2-enyl)azaniumyl]methyl]-3,13-diazapentacyclo[11.7.0.03,11.04,9.014,19]icosa-1(20),4,6,8,10,14,16,18-octaen-10-yl]methyl-dimethyl-prop-2-enylazanium;dibromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL206666
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
Methyl (2R)-2-[(1S,2R,3S,6S,8S,10S)-10-tert-butyl-2-hydroxy-16-methoxy-3-methyl-4,14-dioxo-5,13,15-trioxapentacyclo[7.5.2.0^{1,8}.0^{2,6}.0^{8,12}]hexadecan-9-yl]-2-methoxyacetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL223081; BDBM50208067
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
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[3] | ||
| Glycine receptor subunit alpha-2 |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
2-[(1R,11S,13S,17S,18R,20R,27S,29R,30R,31S,35E)-19-Phenyl-21-oxa-8,14,19,26-tetraazadecacyclo[24.5.2.2^{11,14}.0^{1,27}.0^{2,7}.0^{8,31}.0^{10,18}.0^{13,17}.0^{20,30}.0^{24,29}]pentatriaconta-2,4,6,9,23-pentaen-35-ylidene]ethan-1-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL388048; BDBM50220059
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
(1S,6R,8S,9S,11R,12R,13S,16S,17R)-8-Tert-butyl-6,12,17-trihydroxy-16-methyl-9-(methylamino)-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecane-5,15,18-trione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL222345; BDBM50208086
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
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[3] | ||
| Glycine receptor subunit alpha-2 |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2E)-2-[(1S,9Z,11S,13S,17R,18R,20R,27S,29R,30R,31S)-14,26-Di(cyclohex-2-en-1-yl)-19-phenyl-21-oxa-8,19-diaza-14,26-diazoniadecacyclo[24.5.2.211,14.01,27.02,7.08,31.010,18.013,17.020,30.024,29]pentatriaconta-2,4,6,9,23-pentaen-35-ylidene]ethanol;dibromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL415569
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
(1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-15,31-Bis[(4-nitrophenyl)methyl]-24-phenyl-10,26-dioxa-8,24-diaza-15,31-diazoniaundecacyclo[29.5.2.01,32.02,7.08,36.09,22.013,21.015,19.018,23.025,35.029,34]octatriaconta-2,4,6,12,28-pentaene;dibromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL229998
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
(1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-24-Phenyl-15,31-bis(prop-2-enyl)-10,26-dioxa-8,24-diaza-15,31-diazoniaundecacyclo[29.5.2.01,32.02,7.08,36.09,22.013,21.015,19.018,23.025,35.029,34]octatriaconta-2,4,6,12,28-pentaene;dibromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL390135
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
(1S,6R,8S,9S,11R,12R,13S,16S,17R)-8-Tert-butyl-6,12,17-trihydroxy-16-methyl-5,15,18-trioxo-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecan-9-yl acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL373832; BDBM50208069
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[3] | ||
| Glycine receptor subunit alpha-2 |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-15,31-Dimethyl-24-phenyl-10,26-dioxa-8,24-diaza-15,31-diazoniaundecacyclo[29.5.2.01,32.02,7.08,36.09,22.013,21.015,19.018,23.025,35.029,34]octatriaconta-2,4,6,12,28-pentaene;diiodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL395727
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
(1S,8S,11S,13S,16S,17R)-8-Tert-butyl-17-hydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecane-5,6,15,18-tetrone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL376302; BDBM50208090
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
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[3] | ||
| Glycine receptor subunit alpha-2 |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
(2E)-2-[(9Z,11S,13S,17S,25Z,27S,33S,35S,36S,38E)-38-(2-Hydroxyethylidene)-14,30-dimethyl-8,24-diaza-14,30-diazoniaundecacyclo[25.5.2.211,14.11,26.110,17.02,7.013,17.018,23.030,33.08,35.024,36]octatriaconta-2,4,6,9,18,20,22,25-octaen-28-ylidene]ethanol;dichloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL231047
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
(1R,2R,3S,6S,8S,10R,11R)-10-Tert-butyl-2,11,16-trihydroxy-3-methyl-5,13,15-trioxapentacyclo[7.5.2.0^{1,8}.0^{2,6}.0^{8,12}]hexadecane-4,14-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL374102; BDBM50208066
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[3] | ||
| Glycine receptor subunit alpha-2 |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(1S,6R,8S,9S,11R,12R,13S,16S,17R)-8-Tert-butyl-9-(ethylamino)-6,12,17-trihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecane-5,15,18-trione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL374058; BDBM50208061
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[3] | ||
| Glycine receptor subunit alpha-2 |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(6R,8S,11S,16R,17S)-8-Tert-butyl-6,16,17-trihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecane-5,15,18-trione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL373436; BDBM50208078
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
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[3] | ||
| Glycine receptor subunit alpha-2 |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2E)-2-[(1S,9Z,11S,13S,14R,17S,25Z,27S,33S,35S,36S,38E)-38-(2-Hydroxyethylidene)-14,30-bis(prop-2-enyl)-8,24-diaza-14,30-diazoniaundecacyclo[25.5.2.211,14.11,26.110,17.02,7.013,17.018,23.030,33.08,35.024,36]octatriaconta-2,4,6,9,18,20,22,25-octaen-28-ylidene]ethanol
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Investigative | Compound Info | ||
| Synonyms |
Alcuronium; CHEMBL1180293
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
(1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-15,31-Bis[(E)-but-2-enyl]-24-phenyl-10,26-dioxa-8,24-diaza-15,31-diazoniaundecacyclo[29.5.2.01,32.02,7.08,36.09,22.013,21.015,19.018,23.025,35.029,34]octatriaconta-2,4,6,12,28-pentaene;dibromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL230952
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
(1R,6R,8S,11R)-8-Tert-butyl-13-methoxy-5,15,16-trioxo-2,4,14,17-tetraoxapentacyclo[8.5.2.0^{1,11}.0^{3,7}.0^{7,11}]heptadecan-6-yl acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL221937; BDBM50208079
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[3] | ||
| Glycine receptor subunit alpha-2 |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2E)-2-[(1S,9Z,11S,13S,17R,18R,20R,27S,29R,30R,31S)-14,26-Dimethyl-19-phenyl-21-oxa-8,19-diaza-14,26-diazoniadecacyclo[24.5.2.211,14.01,27.02,7.08,31.010,18.013,17.020,30.024,29]pentatriaconta-2,4,6,9,23-pentaen-35-ylidene]ethanol;diiodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL415568
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
(2E)-2-[(1S,9Z,11S,13S,18R,20R,27S,29R,30R,31S)-14,26-Bis[(4-nitrophenyl)methyl]-19-phenyl-21-oxa-8,19-diaza-14,26-diazoniadecacyclo[24.5.2.211,14.01,27.02,7.08,31.010,18.013,17.020,30.024,29]pentatriaconta-2,4,6,9,23-pentaen-35-ylidene]ethanol;dibromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL415570
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| Activity | Glycine receptor subunit alpha-1 |
IC50 ~ 100000 nM
|
[1] | ||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-[(1H-Indol-3-yl)methylidene]-1,3-dimethylimidazolidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2398350; DTXSID80766834; BDBM50436166; (E)-5-((1H-Indol-3-yl)methylene)-1,3-dimethylimidazolidine-2,4-dione
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| Activity | Glycine receptor subunit alpha-1 |
IC50 > 200000 nM
|
[2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine re... J Med Chem. 2007 Sep 20;50(19):4616-29. | ||||
| REF 2 | Australian marine sponge alkaloids as a new class of glycine-gated chloride channel receptor modulator. Bioorg Med Chem. 2013 Jul 15;21(14):4420-5. | ||||
| REF 3 | Probing the pharmacophore of ginkgolides as glycine receptor antagonists. J Med Chem. 2007 Apr 5;50(7):1610-7. | ||||
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